INT58003

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Context Info
Confidence 0.80
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 13.75
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
plasma 1
PC-12 1
T98G 1
plaques 1
vesicle 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 32 100.00 Very High Very High Very High
agonist 15 99.60 Very High Very High Very High
Neuropeptide 6 99.60 Very High Very High Very High
bradykinin 4 98.94 Very High Very High Very High
cytokine 15 98.84 Very High Very High Very High
cINOD 43 97.50 Very High Very High Very High
Inflammatory response 2 94.00 High High
Neurotransmitter 7 93.24 High High
Kinase C 14 89.76 High High
Opioid 1 89.52 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 173 100.00 Very High Very High Very High
Targeted Disruption 33 100.00 Very High Very High Very High
Anaplastic Astrocytoma 2 100.00 Very High Very High Very High
Amyloid Plaque 30 99.66 Very High Very High Very High
Neurodegenerative Disease 137 97.52 Very High Very High Very High
INFLAMMATION 63 97.22 Very High Very High Very High
Disease 714 96.72 Very High Very High Very High
Stress 42 95.92 Very High Very High Very High
Autism 4 95.76 Very High Very High Very High
Aggression 4 94.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Localization (secreted) of APP
1) Confidence 0.80 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.61 Pain Relevance 0
It is of interest that while OSBP1 overexpression produced no obvious changes in the localization of APP, an altered localization of APP-Notch2 dimers was detected.
Localization (localization) of APP
2) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
It is of interest that while OSBP1 overexpression produced no obvious changes in the localization of APP, an altered localization of APP-Notch2 dimers was detected.
Localization (localization) of APP
3) Confidence 0.78 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
Co-expressing OSBP1 with an APP-GFP construct indicated that OSBP1 did not affect the gross intracellular distribution of APP, in the presence or absence of OSBP1 ligand 25OH (Figure 4A).
Localization (distribution) of APP
4) Confidence 0.73 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
When OSBP1 was not overexpressed, 25OH had no effect on the localization of the APP-Notch2 dimers, perhaps because basal levels of OSBP1 were not high enough to counteract the effects of 25OH binding to other ORPs or LXRs.
Localization (localization) of APP
5) Confidence 0.73 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.05 Pain Relevance 0
HV68 viruses that express HA-tagged WT (referred to as HA-WT) or mutant forms of vBcl-2 including AAA, ??
Localization (referred) of AAA
6) Confidence 0.73 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Localization (secreted) of APP
7) Confidence 0.70 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.62 Pain Relevance 0
Our present results indicate that the localization of APP-Notch2 dimers could also influence the processing of APP, and therefore suggests that APP heterodimers may play an important role in the regulation of APP trafficking and A?
Localization (localization) of APP
8) Confidence 0.69 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
OSBP1 overexpression did not appear to produce changes in APP subcellular localization.
Localization (localization) of APP
9) Confidence 0.68 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0
and secreted sAPP?
Localization (secreted) of sAPP
10) Confidence 0.68 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
(for secreted APP?)
Localization (secreted) of APP
11) Confidence 0.66 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.45 Pain Relevance 0
-site cleavage and shift in subcellular APP localization from ER and plasma membrane to Golgi and early endosomes [49].
Localization (localization) of APP in plasma
12) Confidence 0.64 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.09 Pain Relevance 0
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Localization (secreted) of APP
13) Confidence 0.61 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.62 Pain Relevance 0
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Localization (secreted) of APP
14) Confidence 0.61 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.61 Pain Relevance 0
Overexpression of OSBP1 inhibited APP processing and sAPP secretion
Localization (secretion) of sAPP
15) Confidence 0.60 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
secretion, and it unexpectedly hampered the increase in secreted sAPP?
Localization (secreted) of sAPP
16) Confidence 0.60 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
-sAPP decreased in both patients and controls during a 10 year follow-up [3].
Localization (decreased) of sAPP
17) Confidence 0.59 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 0.77 Pain Relevance 0.16
-secretase to cleave APP (Zecca et al., 2004) or by facilitating A?
Localization (cleave) of APP
18) Confidence 0.58 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 1.25 Pain Relevance 0.04
-secretase to cleave APP (Zecca et al., 2004) or by facilitating A?
Localization (facilitating) of APP
19) Confidence 0.58 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2917219 Disease Relevance 1.21 Pain Relevance 0.04
Electrically stimulated rat hippocampal slices released two times more amino-terminal APP derivatives than unstimulated control slices.
Localization (released) of APP
20) Confidence 0.54 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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