INT58004

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.10
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
PC-12 2
vesicle 2
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 13 100.00 Very High Very High Very High
Neuropeptide 4 99.88 Very High Very High Very High
bradykinin 2 99.22 Very High Very High Very High
cINOD 2 97.50 Very High Very High Very High
agonist 2 97.16 Very High Very High Very High
Neurotransmitter 2 90.52 High High
Kinase C 2 90.32 High High
Opioid 1 89.52 High High
Enkephalin 3 89.24 High High
Pyramidal cell 8 69.92 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 29 98.34 Very High Very High Very High
INFLAMMATION 3 97.22 Very High Very High Very High
Autism 2 95.76 Very High Very High Very High
Aggression 2 94.00 High High
Neurodegenerative Disease 4 93.36 High High
Toxicity 4 90.04 High High
Injury 2 77.48 Quite High
Disease 139 67.96 Quite High
Drug Induced Neurotoxicity 2 53.36 Quite High
Amyloidosis 16 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Positive_regulation (levels) of Localization (secreted) of APP
1) Confidence 0.46 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.62 Pain Relevance 0
Higher levels of secreted APP and nonamyloidogenic secreted APP and lower levels of A?
Positive_regulation (levels) of Localization (secreted) of APP
2) Confidence 0.40 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC1824787 Disease Relevance 0.62 Pain Relevance 0
Carbachol increased the release of large amino-terminal APP-fragments 4- to 6-fold in cell lines expressing the m1 or m3 receptors but not in those expressing m2 or m4 subtypes.
Positive_regulation (increased) of Localization (release) of APP
3) Confidence 0.36 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.15 Pain Relevance 0.15
To determine whether additional cell-surface receptor types linked to this signal transduction pathway could also regulate APP processing, we stimulated differentiated PC-12 cells with bradykinin and found that this neuropeptide also increased the secretion of amino-terminal APP derivatives.
Positive_regulation (increased) of Localization (secretion) of APP in PC-12 associated with neuropeptide and bradykinin
4) Confidence 0.36 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.07 Pain Relevance 0.28
Furthermore, new results using these strategies have identified secretory vesicle cathepsin B for the production of beta-amyloid (Abeta) in the major regulated secretory pathway that provides activity-dependent secretion of Abeta peptides, which accumulate in AD. 3.
Positive_regulation (accumulate) of Localization (secretion) of Abeta in vesicle associated with alzheimer's dementia and abeta
5) Confidence 0.21 Published 2006 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16724274 Disease Relevance 0.48 Pain Relevance 0.40
In addition, the non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen and sulindac sulfide have no effect on the formation and turnover of Abeta(46), but rather modulate the ratio of secreted Abeta at a step after the formation of Abeta(40) and Abeta(42).
Positive_regulation (formation) of Localization (secreted) of Abeta associated with inflammation, cinod and abeta
6) Confidence 0.09 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17241131 Disease Relevance 0.15 Pain Relevance 0.67

General Comments

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