INT58005

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 12.43
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
M-1 6
oocytes 2
neutrophils 2
macrophage 1
sputum 1
M1 (Homo sapiens)
Pain Link Frequency Relevance Heat
primary somatosensory cortex 102 99.84 Very High Very High Very High
Spinal cord 65 98.44 Very High Very High Very High
Inflammation 241 98.40 Very High Very High Very High
agonist 181 98.00 Very High Very High Very High
antagonist 43 97.68 Very High Very High Very High
Inflammatory mediators 29 97.20 Very High Very High Very High
Clonidine 6 96.48 Very High Very High Very High
tetrodotoxin 8 94.24 High High
Multiple sclerosis 116 90.56 High High
isoflurane 5 89.92 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 71 99.56 Very High Very High Very High
Neuromyelitis Optica 994 99.44 Very High Very High Very High
Pulmonary Disease 306 98.48 Very High Very High Very High
INFLAMMATION 276 98.40 Very High Very High Very High
Sarcoidosis 120 98.00 Very High Very High Very High
Hypersensitivity 30 98.00 Very High Very High Very High
Nicotine Addiction 54 97.20 Very High Very High Very High
Syndrome 163 94.48 High High
Demyelinating Disease 170 90.56 High High
Lymphocytosis 3 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional (rabbit vas deferens, guinea pig heart (force) and ileum) as well as binding experiments (m1 and m4 human muscarinic receptors expressed in CHO-K1 cells: M2 and M3 receptors of rat heart and submaxillary gland membranes) were used to evaluate the antimuscarinic activity of the enantiomers.
Gene_expression (expressed) of m1 in vas deferens
1) Confidence 0.78 Published 1996 Journal Life Sci. Section Abstract Doc Link 8649199 Disease Relevance 0 Pain Relevance 0
Western analysis revealed no difference in quantitative expression of m1 and m4 receptor protein in the dorsal spinal cord of spinal nerve-injured animals compared with sham-operated controls, suggesting this interaction with m4 receptors does not reflect an increase in receptor expression.
Gene_expression (expression) of m1 in dorsal associated with spinal cord
2) Confidence 0.51 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12707142 Disease Relevance 0.57 Pain Relevance 1.17
In contrast to our negative findings regarding macrophage polarization, previous studies have demonstrated higher expression of the M1 markers CXCL10 [6], CXCL11 [7] and CXCL16 [8] in sarcoidosis patients compared to healthy subjects.
Gene_expression (expression) of M1 in macrophage associated with sarcoidosis
3) Confidence 0.23 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.36 Pain Relevance 0.10
Cells in M1 showed clear ICMS (13–18 biphasic pulses, 300?
Gene_expression (Cells) of M1
4) Confidence 0.22 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0
m/s, they are greatly outnumbered by fibers with lower conduction velocity (Swadlow, 1990, 1991, 1994); the mean conduction velocity for axons projecting from M1 to S1 has been estimated as 0.9?
Gene_expression (projecting) of M1 associated with primary somatosensory cortex
5) Confidence 0.22 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2927302 Disease Relevance 0 Pain Relevance 0.13
Carbachol increased the release of large amino-terminal APP-fragments 4- to 6-fold in cell lines expressing the m1 or m3 receptors but not in those expressing m2 or m4 subtypes.
Gene_expression (expressing) of m1
6) Confidence 0.18 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.14 Pain Relevance 0.15
We next freshly isolated AMs, using flow cytometric cell sorting, and measured the relative gene expression of a wide range of different M1 and M2 markers.
Gene_expression (expression) of M1
7) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.40 Pain Relevance 0
The relative gene expression of several M1 and M2 associated markers was quantified in cultured total BAL cells and sorted AMs from sarcoidosis patients, with or without Löfgren's syndrome, and healthy subjects.
Gene_expression (expression) of M1 associated with syndrome and sarcoidosis
8) Confidence 0.18 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.37 Pain Relevance 0
Decoding in M1 and PMd
Gene_expression (Decoding) of M1
9) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0.05 Pain Relevance 0
In both monkeys, one array was implanted in M1 and one in PMd.
Gene_expression (one) of M1
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3006173 Disease Relevance 0.06 Pain Relevance 0.18
In order to investigate whether cell-surface receptor activity can regulate APP processing, HEK 293 cell lines stably expressing human muscarinic acetylcholine receptors (mAChR; subtypes m1, m2, m3, m4) were stimulated with the muscarinic agonist carbachol, and the release of APP derivatives was measured.
Gene_expression (expressing) of m1 associated with agonist
11) Confidence 0.12 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239269 Disease Relevance 0.15 Pain Relevance 0.08
The aim of this study was to analyze serum samples from patients with NMO and controls for the presence and epitope specificity of IgG and IgM anti-AQP4 Abs using an immunofluorescence assay with HEK293 cells expressing M-1 or M-23 human AQP4.
Gene_expression (expressing) of M-1 in M-1 associated with neuromyelitis optica
12) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 1.94 Pain Relevance 0.19
In order to exclude that EmGFP might influence the formation of large arrays compared to the non-fused AQP4 proteins we have also over-expressed M-1 and M-23 proteins without EmGFP.
Neg (without) Gene_expression (expressed) of M-1 in M-1
13) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.52 Pain Relevance 0
Furthermore, both AQP4 isoforms were cloned into the pcDNA3.1 Directional TOPO Expression vector (Invitrogen, Carlsbad, CA, USA), to express M-1 and M-23 AQP4 without the EmGFP fusion protein.
Gene_expression (express) of M-1 in M-1
14) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.27 Pain Relevance 0.12
We observed the same NMO-IgG binding patterns using M-1 and M-23 AQP4 transfected cells without the EmGFP fusion protein, as illustrated in Figure 2.
Neg (without) Gene_expression (transfected) of M-1 in M-1 associated with neuromyelitis optica
15) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.50 Pain Relevance 0
Furthermore, EmGFP fused versus unfused AQP4 M-1 and M-23 transfected cells gave identical results in a subset of 15 M-1 and M-23 seropositive and 15 M-1 and M-23 seronegative patients.


Gene_expression (seropositive) of M-1 in M-1
16) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.12 Pain Relevance 0.12
Furthermore, EmGFP fused versus unfused AQP4 M-1 and M-23 transfected cells gave identical results in a subset of 15 M-1 and M-23 seropositive and 15 M-1 and M-23 seronegative patients.


Gene_expression (unfused) of M-1 in M-1
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.84 Pain Relevance 0.06
Defolliculated Xenopus oocytes expressing recombinant m1 or m3 muscarinic or (for comparison) AT1A angiotensin II receptors were voltage clamped, and Ca(2+)-activated Cl- currents (ICl(Ca)) induced by acetyl-beta-methylcholine (Mch) or angiotensin II were measured in the presence of clinically relevant concentrations of halothane, sevoflurane, desflurane or isoflurane.
Gene_expression (expressing) of m1 in oocytes associated with isoflurane and halothane
18) Confidence 0.09 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924234 Disease Relevance 0.16 Pain Relevance 0.26
The O-demethylation of tramadol was catalysed stereospecific by CYP2D6 in the way that very little (+)-M1 was produced in PMs.


Neg (little) Gene_expression (produced) of M1
19) Confidence 0.07 Published 2006 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 16763825 Disease Relevance 0 Pain Relevance 0
Submucosal glands are innervated, and express functional muscarinic M1 and M3 receptors, roughly in a 1:2 ratio [73,74].
Gene_expression (express) of M1 in glands
20) Confidence 0.06 Published 2006 Journal Respir Res Section Body Doc Link PMC1479816 Disease Relevance 0.35 Pain Relevance 0.13

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