INT58015

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Context Info
Confidence 0.41
First Reported 1993
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
plasma 2
Serpine1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 98.44 Very High Very High Very High
Dismenorea 1 97.36 Very High Very High Very High
cva 1 94.68 High High
Angina 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 5 99.66 Very High Very High Very High
Diabetes Mellitus 1 99.12 Very High Very High Very High
INFLAMMATION 3 98.44 Very High Very High Very High
Metabolic Syndrome 7 98.40 Very High Very High Very High
Dysmenorrhea 1 97.36 Very High Very High Very High
Syndrome 1 96.12 Very High Very High Very High
Abdominal Obesity 1 96.08 Very High Very High Very High
Obesity 4 95.56 Very High Very High Very High
Hemorrhage 1 94.68 High High
Abruptio Placentae 1 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many clinical studies have indicated that the insulin resistance syndrome, which is a situation predisposing to diabetes and ischemic heart disease, may be a major regulator of PAI-1 expression, especially in determining plasma PAI-1 levels.
Regulation (regulator) of Gene_expression (expression) of PAI-1 in plasma associated with coronary artery disease, diabetes mellitus and metabolic syndrome
1) Confidence 0.41 Published 1997 Journal Thromb. Haemost. Section Abstract Doc Link 9198234 Disease Relevance 0.90 Pain Relevance 0
This study investigates the separate and interactive effects of steroid hormones and thrombin on PAI-1, uPA, and tPA expression by term decidual cells (DCs).
Spec (investigates) Regulation (effects) of Gene_expression (expression) of PAI-1
2) Confidence 0.08 Published 2007 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 17403427 Disease Relevance 0.29 Pain Relevance 0.14
Therefore, we propose that increased PAI-1 levels, which are essentially related to the classic metabolic aspect of the insulin resistance syndrome, have to be included in this syndrome.
Regulation (related) of Gene_expression (levels) of PAI-1 associated with syndrome and metabolic syndrome
3) Confidence 0.03 Published 1993 Journal Arterioscler. Thromb. Section Abstract Doc Link 8241109 Disease Relevance 1.43 Pain Relevance 0.33

General Comments

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