INT58032

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.72
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pf4) extracellular region (Pf4) protein complex assembly (Pf4)
molecular_function (Pf4) protein complex (Pf4)
Anatomy Link Frequency
Platelet 8
Pf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 16 100.00 Very High Very High Very High
headache 16 99.80 Very High Very High Very High
cva 12 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 12 99.80 Very High Very High Very High
Heparin-induced Thrombocytopenia 150 94.92 High High
Thrombocytopenia 34 83.48 Quite High
Thrombosis 34 37.92 Quite Low
Syndrome 8 17.52 Low Low
Confusion 2 6.72 Low Low
Thrombosis Related Under Development 10 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Pulmonary Embolism 4 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet aggregation was normal in TH, but the secretion of serotonin and platelet factor 4 (PF4) was significantly increased in response to 0.5 and 2.0 micrograms/ml collagen and to 1.0 mumol/l PAF.
Positive_regulation (increased) of Localization (secretion) of PF4 in Platelet associated with headache and serotonin
1) Confidence 0.67 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242729 Disease Relevance 0.36 Pain Relevance 0.73
Platelet aggregation was normal in TH, but the secretion of serotonin and platelet factor 4 (PF4) was significantly increased in response to 0.5 and 2.0 micrograms/ml collagen and to 1.0 mumol/l PAF.
Positive_regulation (increased) of Localization (secretion) of platelet factor 4 in Platelet associated with headache and serotonin
2) Confidence 0.48 Published 1993 Journal Cephalalgia Section Abstract Doc Link 8242729 Disease Relevance 0.36 Pain Relevance 0.73
When platelets are activated, PF4 is released into the circulation and some of it binds to the platelet surface.
Positive_regulation (activated) of Localization (released) of PF4 in platelets
3) Confidence 0.09 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.45 Pain Relevance 0
Activated platelets release PF4, thus perpetuating the cycle of heparin-induced platelet activation.
Positive_regulation (Activated) of Localization (release) of PF4 in platelet
4) Confidence 0.08 Published 2005 Journal Thromb J Section Body Doc Link PMC1262784 Disease Relevance 0.55 Pain Relevance 0

General Comments

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