INT58038

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.42
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
juvenile 1
brain 1
ovary 1
Drb1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 156 99.76 Very High Very High Very High
Spinal cord 4 97.24 Very High Very High Very High
spinal inflammation 1 96.72 Very High Very High Very High
Kappa opioid receptor 1 95.52 Very High Very High Very High
Opioid 2 94.28 High High
Neuritis 2 93.52 High High
orphanin 2 88.88 High High
Buprenorphine 15 87.28 High High
opiate 1 79.40 Quite High
Analgesic 1 77.08 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 166 99.76 Very High Very High Very High
Syndrome 24 99.66 Very High Very High Very High
Low Back Pain 1 96.72 Very High Very High Very High
Optic Neuritis 2 93.52 High High
Autoimmune Disease 4 81.64 Quite High
Demyelinating Disease 4 75.00 Quite High
Iridocyclitis 1 74.36 Quite High
Disease 28 69.00 Quite High
Arthritis 12 61.36 Quite High
Mononeuropathies 2 48.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversion to MS was positively associated with the DRB1*1501.DQA1*0102.DQB1*0602 haplotype, but the influence of HLA was only significant in patients with disseminated brain lesions at presentation (MRI positive); MS developed in 86% of MRI-positive, DRB1*1501-positive patients compared with 55% of MRI-positive, DRB1*1501-negative patients (p < 0.025).
DRB1 Binding (associated) of in brain
1) Confidence 0.22 Published 1993 Journal Hum. Immunol. Section Abstract Doc Link 8244781 Disease Relevance 0.49 Pain Relevance 0.20
MS and the isolated clinical syndromes were positively associated with DRB1*1501, DQA1*0102, and DQB1*0602; the frequency of these alleles in the latter group was intermediate between that seen in MS patients and healthy controls.
DRB1 Binding (associated) of associated with syndrome
2) Confidence 0.21 Published 1993 Journal Hum. Immunol. Section Abstract Doc Link 8244781 Disease Relevance 0.52 Pain Relevance 0.22
Association to HLA-DRB1*08, HLA-DPB1*0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing spondylitis.
DRB1 Binding (Association) of in juvenile associated with spinal inflammation
3) Confidence 0.14 Published 1995 Journal Hum. Immunol. Section Title Doc Link 8847233 Disease Relevance 0.17 Pain Relevance 0.10
Many SE alleles have been studied, including DRB1, 0101, 0102, 0104, 0401, 0404, 0405, and 0408, and among them, 0101, 0401 and 0404 were highly associated with RA in Caucasians (54–57).
DRB1 Binding (associated) of associated with rheumatoid arthritis
4) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717818 Disease Relevance 1.10 Pain Relevance 0.47
Recently, the North American RA Consortium family cohort and the Study of New Onset RA cohort further investigated 1723 Caucasian RA patients and reconfirmed that HLA-DRB1 SE was strongly associated with anti-CCP (63).
DRB1 Binding (associated) of associated with rheumatoid arthritis
5) Confidence 0.03 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717818 Disease Relevance 1.14 Pain Relevance 0.54
Chinese hamster ovary cells stably transfected with each receptor were used for receptor binding and [(35)S]GTP gamma S binding.
receptor binding Binding (binding) of in ovary
6) Confidence 0.00 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11303059 Disease Relevance 0 Pain Relevance 1.46

General Comments

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