INT58042

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Context Info
Confidence 0.24
First Reported 1993
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 5.03
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DQA1) Golgi apparatus (HLA-DQA1) endoplasmic reticulum (HLA-DQA1)
plasma membrane (HLA-DQA1)
Anatomy Link Frequency
leukocyte 2
hematopoietic stem cell 1
sympathetic 1
immune system 1
HLA-DQA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rsd 5 99.76 Very High Very High Very High
Spinal cord 2 97.24 Very High Very High Very High
agonist 2 95.76 Very High Very High Very High
Multiple sclerosis 61 94.52 High High
Neuritis 1 93.52 High High
spinal inflammation 44 62.24 Quite High
cytokine 19 41.60 Quite Low
Inflammation 6 40.48 Quite Low
rheumatoid arthritis 38 39.12 Quite Low
chemokine 5 36.56 Quite Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 227 99.76 Very High Very High Very High
Reflex Sympathetic Dystrophy 5 99.76 Very High Very High Very High
Syndrome 39 99.66 Very High Very High Very High
Disease 160 99.52 Very High Very High Very High
Disease Susceptibility 23 98.40 Very High Very High Very High
Demyelinating Disease 62 94.52 High High
Graft Vs Host Disease 52 94.48 High High
Cytomegalovirus Infection 20 94.44 High High
Heart Disease 2 94.08 High High
Optic Neuritis 1 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent clinical data indicate that HLA-C matching also affects the clinical outcomes of hematopoietic stem cell transplantation, but HLA-DQ and HLA-DP do not appear critical.27,28
HLA-DQ Binding (critical.27,28) of in hematopoietic stem cell
1) Confidence 0.24 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.22 Pain Relevance 0
Class I molecules consist of glycosylated heavy chains encoded by the HLA class I genes and noncovalently bound extracellular ?
HLA class I Binding (bound) of
2) Confidence 0.20 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.10 Pain Relevance 0
HLA-DQ1 associated with reflex sympathetic dystrophy.
HLA-DQ1 Binding (associated) of in sympathetic associated with rsd
3) Confidence 0.19 Published 1999 Journal Neurology Section Title Doc Link 10522900 Disease Relevance 0.39 Pain Relevance 0.47
Within Panel 3, we also studied CEHs, ranging over 2.6 Mb, consisting of their HLA class I loci (Table 2) along with the class II HLA-DRB1 locus and the closely-linked complement genes BF, C2, C4A and C4B (the complotype; Table 3).
HLA class I Binding (loci) of
4) Confidence 0.18 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0
These are subsequently transported into the RER where they bind HLA class I molecules combined with ?
HLA class I Binding (bind) of
5) Confidence 0.13 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.37 Pain Relevance 0.03
Variation in the interaction of other molecules that bind to HLA class I and monitor HLA class I expression, including leukocyte Ig-like receptors (LIRs), members of the Ly49 family (Ly49) and the CD94/NKG2 family of receptors, could also provide another mechanism by which HLA class I could lead to AID [76, 77, 83].
HLA class I Binding (bind) of in leukocyte associated with autoimmune disease
6) Confidence 0.11 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.27 Pain Relevance 0.05
This process involves ubiquitination of endogenous cytosolic proteins and then degradation into short 8-16 amino acid peptides, optimal for HLA class I binding.
HLA class I Binding (binding) of
7) Confidence 0.11 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.39 Pain Relevance 0.03
HLA class I molecules present endogenous antigens, such as those derived from viruses and intracellular bacteria, for recognition by the immune system (see Fig. 1).
HLA class I Binding (recognition) of in immune system
8) Confidence 0.10 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.56 Pain Relevance 0.09
Several non-mutually exclusive mechanisms have been proposed to explain association of DR/DQ with AIDs:
DQ Binding (association) of associated with autoimmune disease
9) Confidence 0.10 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.74 Pain Relevance 0.17
Recently, with the clinical application of molecular genetic technology, human leukocyte antigen (HLA) polymorphisms associated with several diseases have been identified by DNA analysis.
leukocyte antigen Binding (associated) of in leukocyte associated with disease
10) Confidence 0.05 Published 2007 Journal Pediatr Cardiol Section Abstract Doc Link PMC2267487 Disease Relevance 0.61 Pain Relevance 0
TCE and two of its key metabolites, TCA and DCA, have been characterized as weak peroxisome proliferators.
DCA Binding (metabolites) of
11) Confidence 0.03 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1570079 Disease Relevance 0.29 Pain Relevance 0.09
Binding of Class-I HLA multimers (panels a–c, horizontal axes) was analysed in relation to CD8 expression.
Class-I HLA Spec (analysed) Binding (Binding) of
12) Confidence 0.01 Published 2007 Journal Cancer Immunol Immunother Section Body Doc Link PMC1914259 Disease Relevance 0.57 Pain Relevance 0
MS and the isolated clinical syndromes were positively associated with DRB1*1501, DQA1*0102, and DQB1*0602; the frequency of these alleles in the latter group was intermediate between that seen in MS patients and healthy controls.
DQA1 Binding (associated) of associated with syndrome
13) Confidence 0.01 Published 1993 Journal Hum. Immunol. Section Abstract Doc Link 8244781 Disease Relevance 0.52 Pain Relevance 0.22

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