INT58050

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2003
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
CeA 2
olfactory bulb 2
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 99.20 Very High Very High Very High
Potency 1 98.56 Very High Very High Very High
amygdala 5 96.66 Very High Very High Very High
Enkephalin 1 86.20 High High
opioid receptor 2 81.60 Quite High
Pain 2 79.16 Quite High
Neurotransmitter 1 75.00 Quite High
Opioid 2 68.72 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 7 99.88 Very High Very High Very High
Bordatella Infection 2 73.12 Quite High
Post-traumatic Stress Disorder 2 63.96 Quite High
Phobia 1 59.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, we demonstrate that (1) psychogenic stressors influence the in vivo release of CRH at the central nucleus of the amygdala (CeA); (2) although CRH changes within the CeA are exquisitely sensitive to stressors, they are also elicited by positive stimuli; and (3) while treatment with diazepam attenuates behavioral signs of anxiety, the CRH release associated with a stressor is unaffected by the treatment.
Neg (unaffected) Regulation (unaffected) of CRH Binding (associated) of in CeA associated with anxiety disorder and amygdala
1) Confidence 0.42 Published 2003 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 14659475 Disease Relevance 0.70 Pain Relevance 0.38
CCh also fails to affect 125I-CRH binding to olfactory bulb membranes.
Neg (fails) Regulation (affect) of CRH Binding (binding) of in olfactory bulb
2) Confidence 0.23 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8245971 Disease Relevance 0.13 Pain Relevance 0.47

General Comments

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