INT5806

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2010
Negated 8
Speculated 10
Reported most in Abstract
Documents 63
Total Number 72
Disease Relevance 23.46
Pain Relevance 13.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
vas deferens 5
smooth muscle 4
retina 3
blood 3
plasma 2
Edn1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 42 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
Intracerebroventricular 1 100.00 Very High Very High Very High
antagonist 111 99.96 Very High Very High Very High
Clonidine 15 99.92 Very High Very High Very High
Inflammation 35 99.84 Very High Very High Very High
nociceptor 20 99.84 Very High Very High Very High
agonist 53 99.64 Very High Very High Very High
mu opioid receptor 2 99.60 Very High Very High Very High
Spinal cord 16 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 87 100.00 Very High Very High Very High
Myocardial Infarction 11 100.00 Very High Very High Very High
Natriuresis 10 100.00 Very High Very High Very High
Lung Injury 2 99.96 Very High Very High Very High
Reprotox - General 2 144 99.84 Very High Very High Very High
INFLAMMATION 45 99.84 Very High Very High Very High
Cancer 35 99.80 Very High Very High Very High
Hyperglycemia 33 99.56 Very High Very High Very High
Epilepsy 2 99.56 Very High Very High Very High
Diabetes Mellitus 599 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a modulation of the endothelin-1 effects by yohimbine, rather than by clonidine, via postjunctional mechanisms, cannot be excluded.
Regulation (modulation) of endothelin-1 associated with clonidine
1) Confidence 0.62 Published 1992 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1463373 Disease Relevance 0 Pain Relevance 0.45
The aim of this study was to assess the influence of endothelin-1 (ET-1) on cholinergic nerve-mediated contractions in rat isolated tracheal smooth muscle by use of electrical-field stimulation (EFS) and [3H]choline efflux studies.
Regulation (influence) of endothelin-1 in smooth muscle
2) Confidence 0.62 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8968335 Disease Relevance 0 Pain Relevance 0.10
The aim of this study was to assess the influence of endothelin-1 (ET-1) on cholinergic nerve-mediated contractions in rat isolated tracheal smooth muscle by use of electrical-field stimulation (EFS) and [3H]choline efflux studies.
Regulation (influence) of ET-1 in smooth muscle
3) Confidence 0.62 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8968335 Disease Relevance 0 Pain Relevance 0.10
Interactions between the effects of endothelin-1, clonidine and yohimbine on electrically-induced contractions in rat vas deferens.
Regulation (effects) of endothelin-1 in vas deferens associated with clonidine
4) Confidence 0.62 Published 1992 Journal Gen. Pharmacol. Section Title Doc Link 1511861 Disease Relevance 0 Pain Relevance 0.57
These results show that ET-1 and angiotensin II can regulate ET-1 receptors and suggest a possible modulation of ET-1 activity by endogenous levels of the two peptides.
Spec (possible) Regulation (modulation) of ET-1
5) Confidence 0.60 Published 1990 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2175581 Disease Relevance 0 Pain Relevance 0.14
In this study, we have compared the regulation of ET-1 receptors induced by ET-1 and by angiotensin II.
Regulation (regulation) of ET-1
6) Confidence 0.60 Published 1990 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2175581 Disease Relevance 0 Pain Relevance 0.16
In the present study, we studied the effect of endothelin-1 (ET-1) on muscle contraction and ion transport in the rat colon.
Regulation (effect) of ET-1 in colon
7) Confidence 0.45 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625210 Disease Relevance 0 Pain Relevance 0.09
In the present study, we studied the effect of endothelin-1 (ET-1) on muscle contraction and ion transport in the rat colon.
Regulation (effect) of endothelin-1 in colon
8) Confidence 0.45 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1625210 Disease Relevance 0 Pain Relevance 0.09
The effects of endothelin-1 on the tone of the epididymal portion of the rat vas deferens were studied under treatment with drugs modulating the electrically evoked (single pulses, 1 msec, 80 V, 0.1 Hz) contractile responses.
Regulation (effects) of endothelin-1 in vas deferens
9) Confidence 0.45 Published 1992 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 1463373 Disease Relevance 0 Pain Relevance 0.14
Drug-induced modulation of endothelin-1 effects on the tone of electrically stimulated rat vas deferens.
Regulation (modulation) of endothelin-1 in vas deferens
10) Confidence 0.45 Published 1992 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 1463373 Disease Relevance 0 Pain Relevance 0.34
In the absence of confirming data, we decided to further investigate the effects of chronic delivery of exogenous ET-1 on spontaneous and evoked pain sensations in rats.
Spec (investigate) Regulation (effects) of ET-1 associated with pain
11) Confidence 0.45 Published 2009 Journal Journal of pain research Section Body Doc Link PMC3004627 Disease Relevance 0.62 Pain Relevance 0.20
The effects of endothelin-1 (ET-1) on electrically- or drug-induced contractile responses mediated by purinergic or adrenergic receptors were studied in isolated prostatic portion of rat vas deferens.
Regulation (effects) of ET-1 in vas deferens
12) Confidence 0.45 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8429922 Disease Relevance 0 Pain Relevance 0.03
The effects of endothelin-1 (ET-1) on electrically- or drug-induced contractile responses mediated by purinergic or adrenergic receptors were studied in isolated prostatic portion of rat vas deferens.
Regulation (effects) of endothelin-1 in vas deferens
13) Confidence 0.45 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8429922 Disease Relevance 0 Pain Relevance 0.03
The present study was designed to examine the possible influence of hypoxia on plasma immunoreactive (ir) endothelin-1 concentrations in anesthetized rats.
Spec (possible) Regulation (influence) of endothelin-1 in plasma associated with hypoxia
14) Confidence 0.45 Published 1991 Journal Metab. Clin. Exp. Section Abstract Doc Link 1943737 Disease Relevance 0.47 Pain Relevance 0
Effects of endothelin-1 and the ETA-receptor antagonist, BQ123, on ischemic arrhythmias in anesthetized rats.
Regulation (Effects) of endothelin-1 associated with anesthesia and antagonist
15) Confidence 0.45 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 7596133 Disease Relevance 0.30 Pain Relevance 0.23
The effects of intravenous (i.v.) infusions of exogenous endothelin-1 (ET-1, 0.05 and 0.1 nmol/kg/min) on incidence and severity of ventricular arrhythmias during 30-min period of acute myocardial ischemia were assessed in anesthetized rats.
Regulation (effects) of ET-1 associated with coronary artery disease and ischemia
16) Confidence 0.45 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7596133 Disease Relevance 0.21 Pain Relevance 0.12
The effects of intravenous (i.v.) infusions of exogenous endothelin-1 (ET-1, 0.05 and 0.1 nmol/kg/min) on incidence and severity of ventricular arrhythmias during 30-min period of acute myocardial ischemia were assessed in anesthetized rats.
Regulation (effects) of endothelin-1 associated with coronary artery disease and ischemia
17) Confidence 0.45 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7596133 Disease Relevance 0.21 Pain Relevance 0.12
In contrast, HCT-3102 did not affect either response to endothelin-1.
Neg (not) Regulation (affect) of endothelin-1
18) Confidence 0.45 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10924050 Disease Relevance 0.73 Pain Relevance 0.07
We have determined the response of two types of rat gastric smooth muscle to the cumulative addition of endothelin-1 (ET-1).
Spec (determined) Regulation (response) of endothelin-1 in gastric smooth muscle
19) Confidence 0.45 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510018 Disease Relevance 0.07 Pain Relevance 0
We have determined the response of two types of rat gastric smooth muscle to the cumulative addition of endothelin-1 (ET-1).
Spec (determined) Regulation (response) of ET-1 in gastric smooth muscle
20) Confidence 0.45 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510018 Disease Relevance 0.07 Pain Relevance 0

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