INT58060

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 30
Total Number 30
Disease Relevance 11.90
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
external 3
myocytes 1
fibroblasts 1
platelet 1
dome 1
HMI (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 1 99.84 Very High Very High Very High
Angina 8 99.80 Very High Very High Very High
Calcium channel 3 99.20 Very High Very High Very High
tetrodotoxin 97 99.08 Very High Very High Very High
Action potential 94 98.60 Very High Very High Very High
antagonist 4 98.40 Very High Very High Very High
sodium channel 17 98.00 Very High Very High Very High
Analgesic 4 97.76 Very High Very High Very High
action potential duration 78 97.08 Very High Very High Very High
conotoxin 3 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Invasive Pulmonary Aspergillosis 87 100.00 Very High Very High Very High
Respiratory Failure 1 100.00 Very High Very High Very High
Cv General 3 Under Development 7 99.80 Very High Very High Very High
Death 22 99.24 Very High Very High Very High
Heart Arrhythmia 155 98.96 Very High Very High Very High
Infection 3 98.56 Very High Very High Very High
Hypokalemia 166 98.40 Very High Very High Very High
Arrhythmias 2 Under Development 176 97.76 Very High Very High Very High
Sepsis 1 96.96 Very High Very High Very High
Arrhythmia Under Development 40 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accelerating the heart rate (decreasing Ito) [28,29] or decreasing the vagal tonus (decreasing IKAch and increasing ICaL) [26,29] for example by atropine infusion [28], can also act, particularly when associated to beta agonist [10].
Negative_regulation (decreasing) of Ito in heart associated with agonist
1) Confidence 0.44 Published 2005 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1502067 Disease Relevance 0.74 Pain Relevance 0.09
Experimentally, class 1A drugs restore the action potential dome, normalize ST segment elevation and prevent arrhythmogenesis by blocking Ito [28].
Negative_regulation (blocking) of Ito in dome associated with action potential
2) Confidence 0.44 Published 2005 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1502067 Disease Relevance 0.72 Pain Relevance 0.14
Inhibitors of oxidative metabolism, 2,4-dinitrophenol (DNP; 100 microM) and cyanide (3 mM) abolished Ito and caused a large increase in the steady-state outward current.
Negative_regulation (abolished) of Ito
3) Confidence 0.42 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8304498 Disease Relevance 0 Pain Relevance 0.09
The essential effect of IPA-RCP may not only be a temporary increase in rSO2 but elevation of the declining curve during RCP.
Negative_regulation (effect) of IPA
4) Confidence 0.41 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2987928 Disease Relevance 0.09 Pain Relevance 0
Moreover, the ITO was also reduced by application of organic Ca2+ channel antagonists such as nifedipine and omega-conotoxin GVIA, indicating that a component of the ITO is somehow dependent on Ca2+ influx.
Negative_regulation (reduced) of ITO associated with antagonist and conotoxin
5) Confidence 0.41 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026789 Disease Relevance 0 Pain Relevance 0.16
The analgesic effect induced by Ipa (60 mg.kg-1, s.c.) was markedly reduced by reserpine (2 mg.kg-1, i.p.) given 24 h before Ipa, which was reversed by combined administration with i.c.v. norepinephrine (NE).
Negative_regulation (reversed) of Ipa associated with analgesic
6) Confidence 0.36 Published 1996 Journal Yao Xue Xue Bao Section Abstract Doc Link 9863250 Disease Relevance 0 Pain Relevance 0.87
However quinidine is also a blocker of the transient outward current Ito [17,28,31].
Negative_regulation (blocker) of Ito
7) Confidence 0.32 Published 2005 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1502067 Disease Relevance 0.60 Pain Relevance 0.17
Blocking Ito counteracts the marked abbreviation of action potentials in epicardial cells and so normalizes ECG pattern and ventricular vulnerability.
Negative_regulation (Blocking) of Ito associated with action potential
8) Confidence 0.32 Published 2005 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1502067 Disease Relevance 0.54 Pain Relevance 0.17
Other agents which block Ito without significant block of INa, such as tedisamil, a drug currently in clinical trials for atrial fibrillation, could also be useful in this situation [20].
Negative_regulation (block) of Ito associated with arrhythmias 2 under development
9) Confidence 0.32 Published 2005 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC1502067 Disease Relevance 1.07 Pain Relevance 0.03
We conclude that metabolic inhibition abolishes Ito in rabbit atrial myocytes and suggest that ATP may be required for the activation of the channel.
Negative_regulation (abolishes) of Ito in myocytes
10) Confidence 0.31 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8304498 Disease Relevance 0 Pain Relevance 0.07
Exposure to Ca(2+)-free solutions containing divalent inorganic cations such as Cd2+ and Ni2+ could cause shifts in voltage-dependency and, thereby, reduce the amplitude of ITO recorded at fixed submaximal potentials, The maximal ITO achievable under these conditions, however, was reduced compared to control.
Negative_regulation (reduced) of ITO
11) Confidence 0.30 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026789 Disease Relevance 0 Pain Relevance 0.16
The ITO was unaffected by tetraethylammonium (TEA), but was blocked by 4-aminopyridine.
Negative_regulation (blocked) of ITO
12) Confidence 0.30 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026789 Disease Relevance 0 Pain Relevance 0.09
Ito in human cardiac myocytes was sensitive to inhibition by 4-AP [18], therefore we determined whether Ito in human fibroblasts could be decreased by 4-AP.
Negative_regulation (decreased) of Ito in fibroblasts
13) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0
Ito (+60 mV) was substantially inhibited by 4-AP to 11.9±1.4 pA/pF from 36.5±2.6 pA/pF (n?
Negative_regulation (inhibited) of Ito
14) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0
The major time-dependent outward current (Ito), was reduced by flecainide in a rate-independent fashion.
Negative_regulation (reduced) of Ito
15) Confidence 0.22 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8246130 Disease Relevance 0.06 Pain Relevance 0.56
Substitution of external Na+ or application of TTX abolished INa, restored voltage control, and reduced Ito1.
Negative_regulation (reduced) of Ito1 in external associated with tetrodotoxin
16) Confidence 0.18 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.25
Inhibition of Ito by amino-amide local anesthetics may be involved in severe cardiotoxic side effects.
Negative_regulation (Inhibition) of Ito associated with local anesthetic
17) Confidence 0.16 Published 2005 Journal Anesthesiology Section Abstract Doc Link 16192772 Disease Relevance 0 Pain Relevance 0.10
Prevalence of IPA
Negative_regulation (Prevalence) of IPA
18) Confidence 0.14 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2823699 Disease Relevance 0.35 Pain Relevance 0
We investigated the outcome of reducing external sodium on the kinetics, gating, and selectivity of Ito1 with a dual-patch electrode technique to record whole cell currents and transmembrane potentials independently of the voltage clamp in canine midmyocardial cells.
Negative_regulation (reducing) of Ito1 in external
19) Confidence 0.13 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.26
Inactivation of INa with a 10-ms prestep to -45 mV decreased Ito1 to the same extent as external Na+ substitution.
Negative_regulation (decreased) of Ito1 in external
20) Confidence 0.13 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.24

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