INT58061

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 32
Speculated 35
Reported most in Abstract
Documents 1117
Total Number 1159
Disease Relevance 451.54
Pain Relevance 637.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 222
DRG 82
sensory neurons 55
nociceptors 35
nerve 27
Trpv1 (Rattus norvegicus)
Trpv1 - S800A (1)
Pain Link Frequency Relevance Heat
qutenza 15149 100.00 Very High Very High Very High
dorsal root ganglion 7056 100.00 Very High Very High Very High
Pain 5040 100.00 Very High Very High Very High
Inflammation 4007 100.00 Very High Very High Very High
agonist 3397 100.00 Very High Very High Very High
antagonist 2913 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2899 100.00 Very High Very High Very High
nociceptor 1639 100.00 Very High Very High Very High
Action potential 1432 100.00 Very High Very High Very High
substance P 1086 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9809 100.00 Very High Very High Very High
Pain 5001 100.00 Very High Very High Very High
INFLAMMATION 3850 100.00 Very High Very High Very High
Nociception 3473 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 116 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 67 100.00 Very High Very High Very High
Urological Neuroanatomy 1128 99.98 Very High Very High Very High
Inflammatory Pain 1090 99.96 Very High Very High Very High
Neuropathic Pain 3525 99.92 Very High Very High Very High
Diabetes Mellitus 234 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage.
Gene_expression (expressed) of VR1 in nerve associated with nervous system injury and inflammation
1) Confidence 0.78 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 16420034 Disease Relevance 0.44 Pain Relevance 0.48
Vanilloid receptor 1 (VR1, TRPV1) is a cation-selective ion channel that is expressed on primary afferent neurons and is upregulated following inflammation and nerve damage.
Gene_expression (expressed) of Vanilloid receptor 1 in nerve associated with nervous system injury and inflammation
2) Confidence 0.78 Published 2006 Journal J. Med. Chem. Section Abstract Doc Link 16420034 Disease Relevance 0.44 Pain Relevance 0.48
In this study, we expressed rat vanilloid receptor 1 (VR1) in various heterologous expression systems using different VR1-encoding vectors, and examined how the VR1 agonists capsaicin and resiniferatoxin affected intracellular calcium.
Spec (examined) Gene_expression (expressed) of VR1 associated with qutenza and agonist
3) Confidence 0.78 Published 2003 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 14618269 Disease Relevance 0 Pain Relevance 0.17
These results extend our previous findings demonstrating that the neonatal treatment of rats with polygodial or drimanial, similar to that reported for capsaicin, produced persistent antinociception in adult animals associated with TRPV1 down-regulation in the spinal cord, but not TRPV1 expression in DRG.
Gene_expression (expression) of TRPV1 in DRG associated with antinociception, qutenza and spinal cord
4) Confidence 0.78 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975683 Disease Relevance 0.19 Pain Relevance 0.92
The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot.
Gene_expression (expression) of TRPV1 in DRG associated with qutenza and spinal cord
5) Confidence 0.78 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975683 Disease Relevance 0.23 Pain Relevance 1.12
The distinct expression of VR1 protein and mRNA was detected in rat gastric mucosal epithelial cell line as well as in the rat stomach and spinal cord by Western blotting and RT-PCR, respectively.
Gene_expression (expression) of VR1 protein in spinal cord associated with spinal cord
6) Confidence 0.78 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12963499 Disease Relevance 0 Pain Relevance 0.49
In the present study, we demonstrated the peripheral expression of VR1 in gastric mucosal epithelial cells and investigated the role of the receptor in cellular protection.
Gene_expression (expression) of VR1 in epithelial cells
7) Confidence 0.78 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12963499 Disease Relevance 0 Pain Relevance 0.25
These findings suggest that VR1 is expressed peripherally in gastric mucosal epithelial cells and plays a cellular protective role.
Gene_expression (expressed) of VR1 in epithelial cells
8) Confidence 0.78 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12963499 Disease Relevance 0 Pain Relevance 0.40
We confirmed the expression of VR1 in muscle cells using the RT-PCR method and Western blot analysis.
Gene_expression (expression) of VR1 in muscle cells associated with vanilloid receptor subtype 1
9) Confidence 0.78 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15907794 Disease Relevance 0 Pain Relevance 0.82
Immunostaining studies with a confocal microscope and an electron microscope indicated that VR1 was present in the sarcoplasmic reticulum (SR), a store of Ca2+.
Gene_expression (present) of VR1 in reticulum associated with vanilloid receptor subtype 1
10) Confidence 0.78 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15907794 Disease Relevance 0 Pain Relevance 0.84
Vanilloid receptor expressed in the sarcoplasmic reticulum of rat skeletal muscle.
Gene_expression (expressed) of Vanilloid receptor in reticulum associated with qutenza
11) Confidence 0.78 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 15907794 Disease Relevance 0 Pain Relevance 1.02
In situ hybridisation revealed the expression of VR1 mRNA in small-to-medium-sized neurones of the dorsal root, trigeminal and vagal ganglia.
Gene_expression (expression) of VR1 mRNA in dorsal root
12) Confidence 0.78 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9708861 Disease Relevance 0.38 Pain Relevance 0.72
We investigated whether rat dental sensory neurons express the vanilloid (capsaicin) receptor (VR1).
Spec (whether) Gene_expression (express) of VR1 in sensory neurons associated with qutenza
13) Confidence 0.78 Published 2001 Journal J. Dent. Res. Section Abstract Doc Link 11499505 Disease Relevance 0.08 Pain Relevance 0.36
Vanilloid receptor expression and capsaicin excitation of rat dental primary afferent neurons.
Gene_expression (expression) of Vanilloid receptor in afferent neurons associated with qutenza
14) Confidence 0.78 Published 2001 Journal J. Dent. Res. Section Title Doc Link 11499505 Disease Relevance 0.08 Pain Relevance 0.80
In the guinea-pig, VR1 is expressed by intrinsic afferent neurones but its mRNA may differ from the rat sequence in the region of the primers.
Gene_expression (expressed) of VR1
15) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11814652 Disease Relevance 0 Pain Relevance 0
VR1-immunoreactivity was localized on fine fibres and expressed by ganglionic cells.
Gene_expression (expressed) of VR1-immunoreactivity
16) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11814652 Disease Relevance 0 Pain Relevance 0
We conclude that VR1 is expressed on fibres and by myenteric neurones.
Gene_expression (expressed) of VR1
17) Confidence 0.78 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11814652 Disease Relevance 0 Pain Relevance 0
Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors.
Gene_expression (expressed) of TRPV1 in neurons associated with qutenza, trigeminal ganglion and nicotine
18) Confidence 0.78 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14657192 Disease Relevance 0.58 Pain Relevance 1.18
Here, we characterize evodiamine as an agonist for rat TRPV1 expressed heterologously in CHO cells.
Gene_expression (expressed) of TRPV1 associated with agonist
19) Confidence 0.78 Published 2004 Journal Org. Biomol. Chem. Section Abstract Doc Link 15305207 Disease Relevance 0 Pain Relevance 0.49
Capsaicin receptor expression in the rat temporomandibular joint.
Gene_expression (expression) of Capsaicin receptor in temporomandibular joint associated with snapping jaw and qutenza
20) Confidence 0.78 Published 2006 Journal Cell Tissue Res. Section Title Doc Link 16541285 Disease Relevance 0.66 Pain Relevance 1.10

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