INT58062

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 66
Total Number 67
Disease Relevance 22.34
Pain Relevance 38.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
DRG 17
neurons 10
nerve 8
sensory neurons 5
spinal cord 5
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1110 100.00 Very High Very High Very High
Calcitonin gene-related peptide 196 100.00 Very High Very High Very High
antagonist 191 100.00 Very High Very High Very High
substance P 93 100.00 Very High Very High Very High
Antinociceptive 64 100.00 Very High Very High Very High
Adelta 9 100.00 Very High Very High Very High
medulla 8 100.00 Very High Very High Very High
member 8 7 100.00 Very High Very High Very High
nav1.8 9 99.98 Very High Very High Very High
dorsal root ganglion 303 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Overactive Bladder 8 100.00 Very High Very High Very High
Ganglion Cysts 394 99.96 Very High Very High Very High
Pain 274 99.92 Very High Very High Very High
Tinnitus 8 99.92 Very High Very High Very High
Neuropathic Pain 270 99.88 Very High Very High Very High
INFLAMMATION 297 99.76 Very High Very High Very High
Pressure And Volume Under Development 30 99.40 Very High Very High Very High
Hyperalgesia 176 99.20 Very High Very High Very High
Peripheral Arterial Disease 5 98.64 Very High Very High Very High
Toxicity 40 98.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in DRG associated with qutenza and spinal cord
1) Confidence 0.59 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975683 Disease Relevance 0.23 Pain Relevance 1.13
Systemic resiniferatoxin administration, however, decreases VR1 expression in dorsal root ganglia by 65-80%, an effect that persists for at least 2 months.
Negative_regulation (decreases) of Gene_expression (expression) of VR1 in dorsal root ganglia
2) Confidence 0.59 Published 2001 Journal Neuroscience Section Abstract Doc Link 11718993 Disease Relevance 0.10 Pain Relevance 0.16
TRPV1 expression in mesenteric resistance arteries and the renal cortex and medulla, calcitonin gene-related peptide levels in dorsal root ganglia, and calcitonin gene-related peptide-positive sensory nerve density in mesenteric resistance arteries were significantly decreased in DS+HS rats compared with DS+LS, DR+HS, and DR+LS rats.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1 in dorsal root ganglia associated with medulla and calcitonin gene-related peptide
3) Confidence 0.59 Published 2006 Journal Hypertension Section Abstract Doc Link 16365187 Disease Relevance 0.23 Pain Relevance 0.33
In contrast, TRPV1 expression and function are impaired in DS rats, which renders DS rats sensitive to salt load in terms of blood pressure regulation.
Negative_regulation (impaired) of Gene_expression (expression) of TRPV1 in blood
4) Confidence 0.59 Published 2006 Journal Hypertension Section Abstract Doc Link 16365187 Disease Relevance 0.22 Pain Relevance 0.26
Decreased pain sensitivity of capsaicin-treated rats results from decreased VR1 expression.
Negative_regulation (decreased) of Gene_expression (expression) of VR1 associated with pain and qutenza
5) Confidence 0.59 Published 2004 Journal Arch. Pharm. Res. Section Title Doc Link 15595420 Disease Relevance 0.42 Pain Relevance 1.53
Therefore, we can conclude that the neurotoxic effect of CAP is related to the decrease of VR1 expression.
Negative_regulation (decrease) of Gene_expression (expression) of VR1 associated with qutenza
6) Confidence 0.59 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15595420 Disease Relevance 0.40 Pain Relevance 1.21
The expression of TRPV1, a specific marker of capsaicin-sensitive small sensory neurons connected to C- and Adelta-fibers, was markedly reduced 3 days after the capsaicin treatment.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in sensory neurons associated with qutenza and adelta
7) Confidence 0.58 Published 2005 Journal Pharmacology Section Abstract Doc Link 15492487 Disease Relevance 0 Pain Relevance 0.91
We found that: (1) all of the compounds dose-dependently inhibited the gastric acid secretion and mucosal damage; (2) the expression of TRPV1 receptor, CGRP and SP decreased significantly in both pylorus-ligated and indomethacin-treated animals and (3) the expression of TRPV1 and CGRP was reduced.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in pylorus
8) Confidence 0.58 Published 2005 Journal Inflammopharmacology Section Abstract Doc Link 16259735 Disease Relevance 0.08 Pain Relevance 0.23
Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals.
Negative_regulation (reduces) of Gene_expression (expression) of TRPV1 in spinal cord associated with overactive bladder, spinal cord and intrathecal
9) Confidence 0.57 Published 2008 Journal Exp. Neurol. Section Title Doc Link 18824169 Disease Relevance 0.87 Pain Relevance 0.63
CONCLUSIONS: These studies suggest that long-term diabetes causes vascular dysfunction in epineurial arterioles of the sciatic nerve that includes a decrease in capsaicin-induced vasoconstriction that is likely due to a decrease in the expression of vanilloid receptor 1.


Negative_regulation (decrease) of Gene_expression (expression) of vanilloid receptor 1 in arterioles
10) Confidence 0.57 Published 2006 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 16196077 Disease Relevance 0 Pain Relevance 0
The latter proposition is supported by the finding that peripheral treatment with anti-GDNF antibodies suppresses the novel expression of TRPV1 in IB4-binding neurons following peripheral inflammation [60].
Negative_regulation (suppresses) of Gene_expression (expression) of TRPV1 in neurons associated with inflammation
11) Confidence 0.55 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.71 Pain Relevance 0.44
Administration of clonidine could decrease VR1 mRNA expression but not SP mRNA.
Neg (not) Negative_regulation (decrease) of Gene_expression (expression) of VR1 mRNA associated with substance p and clonidine
12) Confidence 0.55 Published 2010 Journal Pharmazie Section Abstract Doc Link 20383941 Disease Relevance 0.49 Pain Relevance 2.03
Local injection of this peptide significantly suppressed both thermal and mechanical hyperalgesia produced by CFA and also significantly reduced TRPV1 expression at the DRG.
Negative_regulation (reduced) of Gene_expression (expression) of TRPV1 in DRG associated with dorsal root ganglion and hyperalgesia
13) Confidence 0.54 Published 2010 Journal J. Pharmacol. Sci. Section Abstract Doc Link 20351485 Disease Relevance 0.68 Pain Relevance 0.66
The expression of VR1 in dorsal root ganglia (DRG) isolated from the CAP-treated rats was reduced compared to that from the vehicle-treated rats.
Negative_regulation (reduced) of Gene_expression (expression) of VR1 in dorsal root ganglia associated with qutenza
14) Confidence 0.51 Published 2004 Journal Arch. Pharm. Res. Section Abstract Doc Link 15595420 Disease Relevance 0.44 Pain Relevance 1.31
Retinal ischemia-reperfusion decreased the expression of cannabinoid (CB1) and vanilloid (TRPV1) receptors.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1
15) Confidence 0.48 Published 2007 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 17591864 Disease Relevance 0 Pain Relevance 0
Sacral nerve root stimulation can down-regulate the VR1 expression.


Negative_regulation (down) of Gene_expression (expression) of VR1 in nerve
16) Confidence 0.43 Published 2002 Journal J. Surg. Res. Section Body Doc Link 12384077 Disease Relevance 0.06 Pain Relevance 0
Sacral nerve root stimulation can down-regulate the VR1 expression.


Negative_regulation (regulate) of Gene_expression (expression) of VR1 in nerve
17) Confidence 0.43 Published 2002 Journal J. Surg. Res. Section Body Doc Link 12384077 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Baicalin was shown to down-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and under the latter temperature, the intracellular fluorescent intensity evoked by capsaicin was significantly decreased following incubation with baicalin in vitro.
Negative_regulation (down) of Gene_expression (expression) of TRPV1
18) Confidence 0.43 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20380875 Disease Relevance 0.11 Pain Relevance 0
RESULTS: Baicalin was shown to down-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and under the latter temperature, the intracellular fluorescent intensity evoked by capsaicin was significantly decreased following incubation with baicalin in vitro.
Negative_regulation (decreased) of Gene_expression (expression) of TRPV1
19) Confidence 0.43 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20380875 Disease Relevance 0.11 Pain Relevance 0
Thus, the most likely explanation for the absence of TRPV1 detection in the brain, described by other investigators [3,15], is that their assays were not sensitive enough to detect the lower expression in the brain.
Negative_regulation (absence) of Gene_expression (detection) of TRPV1 in brain
20) Confidence 0.43 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.08 Pain Relevance 0.12

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