INT58069

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
smooth muscle 1
DRG 1
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.98 Very High Very High Very High
dorsal root ganglion 9 99.78 Very High Very High Very High
Nerve growth factor 12 99.04 Very High Very High Very High
antagonist 2 98.20 Very High Very High Very High
sodium channel 6 97.38 Very High Very High Very High
Hyperalgesia 1 86.24 High High
Peripheral nervous system 1 85.12 High High
Antinociceptive 1 83.60 Quite High
mu opioid receptor 2 81.84 Quite High
Morphine 1 81.52 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.78 Very High Very High Very High
Hyperalgesia 1 86.24 High High
Hypertrophy 1 83.80 Quite High
Targeted Disruption 2 77.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When tested in the GPI and MVD smooth muscle preparations, 3 was found to possess one-tenth the agonist activity of beta-FNA is both tissues, but showed no irreversible antagonist activity.
Transcription (activity) of beta-FNA in smooth muscle associated with antagonist and agonist
1) Confidence 0.50 Published 1993 Journal J. Med. Chem. Section Abstract Doc Link 8246236 Disease Relevance 0 Pain Relevance 0.34
Hybridization signals for sodium channel subunits alphaII and beta2 displayed the most substantial enhancement in hyper-NGF mice, compared to wild-type mice DRG, and mRNA levels for alphaI, NaG, Na6, SNS/PN3, NaN, and beta1 were also greater in hyper-NGF DRG.
Transcription (levels) of beta1 in DRG associated with dorsal root ganglion, nerve growth factor and sodium channel
2) Confidence 0.01 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10397634 Disease Relevance 1.06 Pain Relevance 1.25

General Comments

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