INT58079

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.90
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
plasma 1
peptidergic neurons 1
reticulum 1
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 166 100.00 Very High Very High Very High
Pain 220 99.86 Very High Very High Very High
Enkephalin 16 99.76 Very High Very High Very High
hypoalgesia 2 99.68 Very High Very High Very High
substance P 13 99.16 Very High Very High Very High
Opioid 17 98.58 Very High Very High Very High
Lasting pain 22 94.60 High High
depression 6 93.36 High High
Inflammation 58 91.68 High High
narcan 3 90.20 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 230 100.00 Very High Very High Very High
Pain 273 99.86 Very High Very High Very High
Hypoalagesia 2 99.68 Very High Very High Very High
Chronic Disease 2 96.72 Very High Very High Very High
Syndrome 22 96.00 Very High Very High Very High
Peripheral Neuropathy 2 94.84 High High
Depression 6 93.36 High High
Death 14 92.92 High High
Neurogenic Inflammation 12 92.56 High High
Alzheimer's Dementia 276 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In several cases NEP is secreted by cells that have tachykinin receptors.
Localization (secreted) of NEP
1) Confidence 0.68 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.54 Pain Relevance 0.33
Inhibition of NEP by thiorphan or phosphoramidon leads to increased secretion of NEP (Edwards et al. 1999).
Localization (secretion) of NEP
2) Confidence 0.68 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 0.64 Pain Relevance 0.30
These results indicate that both the major opioid-degrading peptidases, i.e. aminopeptidases and neutral endopeptidase (NEP), are individually implicated in the hypoalgesia induced by peptidase inhibitors.
Localization (implicated) of NEP associated with hypoalgesia and opioid
3) Confidence 0.68 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247255 Disease Relevance 0.27 Pain Relevance 0.53
Pain types indicative of NeP occurred much more frequently in patients with LANSS ?
Localization (indicative) of NeP associated with pain and neuropathic pain
4) Confidence 0.57 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 1.40 Pain Relevance 1.14
Our study results are consistent in that the majority of (putative) NeP patients reported their pain affecting social, family and professional life, and spare time.
Localization (reported) of NeP associated with pain and neuropathic pain
5) Confidence 0.49 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 1.73 Pain Relevance 1.51
Thus, ex vivo gene delivery of a soluble, secreted form of human NEP resulted in substantial and significant reductions in A?
Localization (secreted) of NEP
6) Confidence 0.44 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.08 Pain Relevance 0.23
In order to clarify the location of NEP- and sNEP-mediated A?
Localization (location) of NEP
7) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0 Pain Relevance 0
Thus, ex vivo gene delivery of a soluble, secreted form of human NEP resulted in substantial and significant reductions in A?
Localization (form) of NEP
8) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.08 Pain Relevance 0.23
This construct, upon being translated and inserted into the endoplasmic reticulum membrane, has the signal peptide removed to liberate a soluble, secreted form of NEP.
Localization (secreted) of NEP in reticulum
9) Confidence 0.41 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.07 Pain Relevance 0
levels by elevating NEP expression, we evaluated a secreted form of NEP, sNEP.
Localization (secreted) of NEP
10) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1952204 Disease Relevance 0.09 Pain Relevance 0
Neutral endopeptidase EC 3.4.24.11 (NEP) is localized in peptidergic neurons and various colocalized peptides or other humoral mediators may serve as substrates.
Localization (localized) of NEP in peptidergic neurons
11) Confidence 0.36 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9347938 Disease Relevance 0.24 Pain Relevance 0.34
and hAChE peptides are in common and are as follows; His12-Trp13 and Trp13-Lys14 for IDE, and Ser8-Tyr9 for NEP (AChE586-599 peptide numbering)(Figure S2 supporting information).
Localization (follows) of NEP
12) Confidence 0.19 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0
NEP localization at the plasma membrane makes it a candidate for degradation of extracellular A?
Localization (localization) of NEP in plasma
13) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.58 Pain Relevance 0.15
DESIGN: A cohort study was performed examining PGB substitution in patients who were GBP responders (> or =30% NeP relief on a visual analog scale [VAS]) or GBP nonresponders after prolonged GBP use, with further comparison to patients receiving continuous GBP therapy.
Localization (relief) of NeP
14) Confidence 0.09 Published 2010 Journal Pain Med Section Body Doc Link 20113408 Disease Relevance 0.19 Pain Relevance 0

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