INT58083

Context Info Confidence 0.67 First Reported 1993 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 10 Total Number 11 Disease Relevance 3.66 Pain Relevance 7.12

Anatomy Link Frequency Caco-2 1 NG108-15 1 finger 1 neutrophil 1 DYT10 (Homo sapiens)

Pain Link Frequency Relevance Heat Kinase C 33 100.00 depression 15 99.12 Opioid 26 99.02 Enkephalin 17 98.84 agonist 7 97.84 long-term potentiation 3 96.60 analgesia 3 95.76 dexamethasone 5 95.60 narcan 2 95.04 Morphine 12 92.08

Disease Link Frequency Relevance Heat Cancer 11 99.48 Depression 13 99.12 Bordatella Infection 1 98.50 Osteoporosis 4 96.00 Colon Cancer 5 90.40 INFLAMMATION 2 79.32 Pain 8 77.44 Morphine Dependence 2 75.00 Drug Dependence 2 74.52 Cirrhosis 3 74.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibition of AR prevented growth factor-induced COX-2 activity, protein, and mRNA and significantly decreased activation of nuclear factor-kappaB and protein kinase C (PKC) and phosphorylation of PKC-beta2 as well as progression of Caco-2 cell growth but had no effect on COX-1 activity.

Positive_regulation (activation) of PKC in Caco-2 associated with kinase c

1) Confidence 0.67 Published 2006 Journal Cancer Res. Section Abstract Doc Link 17018629 Disease Relevance 0.33 Pain Relevance 0.23

Another and more relevant mechanism of long-term opioid binding is that of subsequent protein kinase C (PKC), phospholipase C (PLC) translocation and activation of nitric oxide synthetase (NOS).

Positive_regulation (activation) of PKC associated with kinase c and opioid

2) Confidence 0.67 Published 2003 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Abstract Doc Link 12522725 Disease Relevance 0.07 Pain Relevance 1.31

This PLC-beta3 phosphorylation was mainly due to PKC activation because pretreatment of NG108-15 cells with calphostin C could block the DPDPE effect.

Positive_regulation (activation) of PKC in NG108-15 associated with kinase c

3) Confidence 0.67 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9614207 Disease Relevance 0.11 Pain Relevance 0.64

We recently found that repeated administration of mu-agonist causes a down regulation of mu-receptor-mediated G-protein activation, which is associated with a specific upregulation of PKC gamma isoform.

Positive_regulation (upregulation) of PKC associated with kinase c and agonist

4) Confidence 0.67 Published 2000 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 11144149 Disease Relevance 0.44 Pain Relevance 1.31

The effect of MENK was mediated through pertussis-toxin (PTX) sensitive G-protein and since it was abolished by H7 probably involves protein kinase C (PKC) as a second messenger system.

Spec (probably) Positive_regulation (involves) of PKC associated with kinase c, bordatella infection and enkephalin

5) Confidence 0.49 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8247257 Disease Relevance 0.10 Pain Relevance 0.88

Signal transduction studies revealed that regulation of OPN was dependent on both protein kinase C (PKC) and the mitogen-activated protein (MAP) kinase cascade.

Positive_regulation (dependent) of PKC associated with kinase c

6) Confidence 0.49 Published 2000 Journal J. Cell. Biochem. Section Abstract Doc Link 10861858 Disease Relevance 1.09 Pain Relevance 0.11

Tumor-promoting phorbol esters activate protein kinase C (PKC) isozymes by binding to the zinc-finger like cysteine-rich domains in the N-terminal regulatory region.

Positive_regulation (activate) of PKC in finger associated with kinase c and cancer

7) Confidence 0.49 Published 1999 Journal Bioorg. Med. Chem. Section Abstract Doc Link 10428394 Disease Relevance 0.17 Pain Relevance 0.16

Regulation by protein phosphorylation was suggested by the observations that the opioid-mediated response was potentiated by calphostin C, an inhibitor of protein kinase C (PKC), and was abolished by either phorbol-12-myristate-13-acetate, a PKC activator, or calyculin A, a protein phosphatase1/2A inhibitor.

Positive_regulation (activator) of PKC associated with kinase c and opioid

8) Confidence 0.49 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9614207 Disease Relevance 0.14 Pain Relevance 0.59

The stability of PKC zeta and PKM zeta in SD indicates that a molecular mechanism for the maintenance of LTP/ LTD is relatively resistant to alterations that occur during pathophysiologically large ionic fluxes.

Positive_regulation (stability) of PKC associated with kinase c, depression and long-term potentiation

9) Confidence 0.49 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014175 Disease Relevance 1.15 Pain Relevance 1.05

Opioid receptor stimulation induced a calcium-dependent protein kinase C alpha (PKC alpha)/extracellular regulated kinase (ERK)/phosphatidylinositol 3-kinase (PI3K) pathway activation that mediated the effect of endogenous opioids on HSC proliferation and collagen synthesis.

Positive_regulation (calcium-dependent) of PKC

10) Confidence 0.49 Published 2008 Journal Gut Section Body Doc Link 17989109 Disease Relevance 0.07 Pain Relevance 0

MENK induced O2- release was associated with a dose-dependent increase of diacylglycerol (DAG) concentration and protein-kinase C (PKC) translocation to the neutrophil membranes, with an increase of cytosolic Ca++, and could be abolished by H7, a PKC inhibitor.

Positive_regulation (increase) of PKC in neutrophil associated with kinase c and enkephalin

11) Confidence 0.45 Published 1996 Journal Neuropeptides Section Abstract Doc Link 8771562 Disease Relevance 0 Pain Relevance 0.83

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