INT58097

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1993
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 1.62
Pain Relevance 4.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
uterus 3
SON 2
PVN 2
brain 1
uterine 1
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 7 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
orphanin 4 100.00 Very High Very High Very High
fluoxetine 6 99.76 Very High Very High Very High
Central nervous system 6 99.74 Very High Very High Very High
agonist 101 99.68 Very High Very High Very High
Neuronal excitability 8 98.96 Very High Very High Very High
Morphine 7 98.52 Very High Very High Very High
Enkephalin 5 98.44 Very High Very High Very High
Dynorphin 4 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 5 95.84 Very High Very High Very High
Dysmenorrhea 8 88.60 High High
Nociception 28 86.04 High High
Neuropathic Pain 2 79.24 Quite High
INFLAMMATION 2 78.12 Quite High
Reprotox - General 1 10 75.00 Quite High
Convulsion 3 75.00 Quite High
Urological Neuroanatomy 1 61.28 Quite High
Obesity 16 23.68 Low Low
Hypersensitivity 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes of oxytocin content and mRNA expression in some nuclei were investigated in morphine-dependent rats using radioimmunoassay (RIA) and in situ hybridization (ISH).
Transcription (expression) of oxytocin associated with morphine
1) Confidence 0.69 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.06 Pain Relevance 0.53
Here we show that in sexually impotent rats there is a reduced expression of oxytocin mRNA and an increased expression of proenkephalin and pro-dynorphin mRNA in the paraventricular nucleus of hypothalamus (PVN), a brain structure of key importance for sexual behavior.
Transcription (expression) of oxytocin in PVN associated with dynorphin
2) Confidence 0.47 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9350833 Disease Relevance 0.07 Pain Relevance 0.42
Specific analysis of the SON, following metrazole, revealed an equivalent effect on VP and OT mRNA levels but a nuclear run-on assay did not detect any change in SON VP gene transcription at 0.5, 1 and 2 h after treatment.
Transcription (levels) of OT in SON
3) Confidence 0.46 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8247343 Disease Relevance 0.07 Pain Relevance 0.08
Levels of hypothalamic vasopressin (VP) and oxytocin (OT) mRNA were significantly reduced at 2 and 4 h after metrazole (50 mg/kg, i.p.), whereas pro-dynorphin mRNA was significantly elevated at 2 h.
Transcription (Levels) of oxytocin associated with dynorphin
4) Confidence 0.46 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8247343 Disease Relevance 0.07 Pain Relevance 0.05
Levels of hypothalamic vasopressin (VP) and oxytocin (OT) mRNA were significantly reduced at 2 and 4 h after metrazole (50 mg/kg, i.p.), whereas pro-dynorphin mRNA was significantly elevated at 2 h.
Transcription (Levels) of OT associated with dynorphin
5) Confidence 0.40 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8247343 Disease Relevance 0.07 Pain Relevance 0.05
In male Wistar rats, we investigated the 5-HT receptors involved in the 5-HT-induced increase of mRNA expression of vasopressin and oxytocin in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).
Transcription (expression) of oxytocin in SON
6) Confidence 0.40 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.10 Pain Relevance 0.34
We conclude that stimulation with 5-hydroxytryptophan or 5-HT agonists increases mRNA expression of oxytocin in the PVN and the SON via stimulation of at least 5-HT1A, 5-HT1B, 5-HT2A and 5-HT2C receptors.
Transcription (expression) of oxytocin in PVN associated with agonist
7) Confidence 0.38 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0 Pain Relevance 0.43
The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
Transcription (expression) of oxytocin in PVN associated with fluoxetine
8) Confidence 0.30 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.09 Pain Relevance 0.44
In most CNS structures, OT is generally described as excitatory, but inhibitory effects are also often seen depending on the concentration used, brain developmental stages, neuronal cell types and hormonal status [25].
Transcription (described) of OT in neuronal associated with central nervous system
9) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780383 Disease Relevance 0.31 Pain Relevance 0.65
Animal studies show that in ewes, the first pregnancy induces permanent changes with regard to the release of oxytocin and oxytocin receptors, e.g. the expression of oxytocin receptor mRNA is increased in the paraventricular nucleus (PVN) of the brain and the sensitivity of oxytocin autoreceptors is increased [29].
Transcription (expression) of oxytocin in brain
10) Confidence 0.24 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1878468 Disease Relevance 0 Pain Relevance 0
Using this method, the ERbeta mRNA coexpressions with the novel opioid neuropeptide (orphanin FQ and its receptor ORL1) mRNA in addition to the previously reported neuropeptide (arginine vasopressin-AVP, oxytocin-OXY, corticotropin releasing hormone-CRH, enkephalin-ENK) mRNAs were assessed.
Transcription (coexpressions) of oxytocin-OXY associated with orphanin, neuropeptide, enkephalin and opioid
11) Confidence 0.20 Published 2003 Journal Anat. Embryol. Section Abstract Doc Link 12690447 Disease Relevance 0 Pain Relevance 0.46
However, treatments with BPA and genistein for 3 days failed to detect the expression level of oxytocin mRNA [see Additional file 1].
Transcription (level) of oxytocin
12) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.08 Pain Relevance 0.08
Estrogen stimulated the number of uterine oxytocin binding sites, and oxytocin receptor mRNA expression in ovariectomized virgin rats [39,40].
Transcription (expression) of oxytocin in uterine
13) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.07 Pain Relevance 0.14
To investigate the regulation of various genes in the uterus of rats during estrous cycle, the expression levels of CaBP-9k, oxytocin, Acrp30, Ldha, and S100a6 mRNA were analyzed by real-time PCR.
Spec (analyzed) Transcription (levels) of oxytocin in uterus
14) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
However, treatments with BPA and genistein for 3 days failed to detect the expression level of oxytocin mRNA [see Additional file 1].
Transcription (expression) of oxytocin
15) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.08 Pain Relevance 0.08
Based on the treatments with EDs, increased expression levels of oxytocin mRNA were observed when rats were treated with OP (14.76-fold) and NP (9.54-fold), and a single dose treatment with DES (5.70-fold) and E2 (5.83-fold) for 3 days.
Transcription (levels) of oxytocin
16) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.09 Pain Relevance 0.09
In parallel with CaBP-9k mRNA, the expression levels of oxytocin (13.4-fold, vs. luteal phase), Acrp30 (3.1-fold, vs. luteal phase), Ldha (3.3-fold, vs. luteal phase), and S100a6 (2.7-fold, vs. luteal phase) mRNAs at follicular phase were up-regulated in this tissue, indicating that they are dominantly expressed during follicular phase and weakly detected at luteal phase in the uterus of mature rats.


Transcription (expression) of oxytocin in uterus
17) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0 Pain Relevance 0
These observations raise the possibility that the increase in the oxytocin mRNA level shown in Figure 3, occurs, at least in part, as a result of the injected estrogenic compounds and that the PCR data and microarray data are in general agreement.
Transcription (level) of oxytocin
18) Confidence 0.12 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.07 Pain Relevance 0.07
The mRNA levels of oxytocin increased 2-fold between metestrus and proestrus by Northern blot analysis during estrous cycle, while oxytocin binding increased more than 10-fold within this same interval in the uterus of rats [40].
Transcription (levels) of oxytocin in uterus
19) Confidence 0.10 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1594574 Disease Relevance 0.06 Pain Relevance 0.06
In most CNS structures, OT is generally described as excitatory, but inhibitory effects are also often seen depending on the concentration used, brain developmental stages, neuronal cell types and hormonal status [25].
Transcription (described) of OT in developmental stages associated with central nervous system
20) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2780383 Disease Relevance 0.31 Pain Relevance 0.65

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox