INT58102

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Context Info
Confidence 0.08
First Reported 1993
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 6.39
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTRF1) cytoplasm (MTRF1)
Anatomy Link Frequency
leukocyte 1
TMJ 1
MTRF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 260 100.00 Very High Very High Very High
Snapping jaw 18 99.66 Very High Very High Very High
Arthritis 20 68.00 Quite High
Osteoarthritis 8 63.28 Quite High
Fibrositis 16 60.44 Quite High
Pain 2 51.80 Quite High
Inflammation 10 41.40 Quite Low
methotrexate 8 5.00 Very Low Very Low Very Low
carpal tunnel syndrome 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 262 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 18 99.66 Very High Very High Very High
Congenital Anomalies 4 99.20 Very High Very High Very High
Arthritis 16 97.48 Very High Very High Very High
Disease 80 92.64 High High
Rheumatic Diseases 20 82.16 Quite High
Communicable Diseases 2 80.56 Quite High
Systemic Lupus Erythematosus 10 65.92 Quite High
Seronegative Spondarthritis 6 64.32 Quite High
Osteoarthritis 8 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The severity of lesions in the temporomandibular joint (TMJ) area and their association with age at onset, the various forms of juvenile rheumatoid arthritis (JRA), and certain serologic tests for rheumatoid factor (RF), antinuclear antibodies (ANA), and human leukocyte antigen (HLA)-B27 were determined in 15-yr-old children.
RF Spec (determined) Binding (association) of in leukocyte associated with snapping jaw and rheumatoid arthritis
1) Confidence 0.08 Published 1993 Journal Scand J Dent Res Section Abstract Doc Link 8248736 Disease Relevance 0.91 Pain Relevance 0.63
RF, ANA, or HLA-B27 alone did not seem to be associated with a risk of TMJ abnormalities.
RF Binding (associated) of in TMJ associated with snapping jaw and congenital anomalies
2) Confidence 0.07 Published 1993 Journal Scand J Dent Res Section Abstract Doc Link 8248736 Disease Relevance 1.44 Pain Relevance 0.98
The ACR criteria for RA diagnosis include the presence of RF, a decision that has contributed to the widely routine use of this test as a diagnostic marker for RA in most clinical laboratories.
RF Binding (presence) of associated with rheumatoid arthritis
3) Confidence 0.03 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 1.33 Pain Relevance 0.44
So far, serological support in the diagnosis of RA was mainly based on the presence of rheumatoid factors (RF) [10].
RF Binding (presence) of associated with rheumatoid arthritis
4) Confidence 0.03 Published 2008 Journal Rheumatol Int Section Body Doc Link PMC2493537 Disease Relevance 1.43 Pain Relevance 0.51
In conclusion, anti-CCP assay by ELISA could be performed more objectively and quantitatively, and showed higher specificity than AFA and RF in patients with RA.
RF Binding (specificity) of associated with rheumatoid arthritis
5) Confidence 0.02 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782206 Disease Relevance 0.73 Pain Relevance 0.24
In conclusion, we consider that anti-CCP could be very useful serological assay for the diagnosis of RA, because anti-CCP revealed higher diagnostic specificity than RF and AFA at the optimal cut off values and could be performed by easy, convenient ELISA method.



RF Binding (specificity) of associated with rheumatoid arthritis
6) Confidence 0.02 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2782206 Disease Relevance 0.55 Pain Relevance 0.25

General Comments

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