INT58108

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.02
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
Oxycodone 10 99.72 Very High Very High Very High
rheumatoid arthritis 5 98.90 Very High Very High Very High
Arthritis 36 91.04 High High
anesthesia 5 85.04 High High
Osteoarthritis 3 76.36 Quite High
diclofenac 1 71.16 Quite High
cINOD 4 70.52 Quite High
Inflammation 2 48.00 Quite Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 4 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 98.90 Very High Very High Very High
Juvenile Chronic Polyarthritis 30 91.04 High High
Osteoarthritis 3 76.36 Quite High
Toxicity 1 75.00 Quite High
INFLAMMATION 5 70.28 Quite High
Disease 24 42.20 Quite Low
Arthritis 6 11.04 Low Low
Alzheimer's Dementia 5 5.00 Very Low Very Low Very Low
Rheumatic Diseases 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data could be clinically relevant, since the drugs examined are used at very high doses in rheumatoid arthritis and related conditions, with plasma levels that could cause significant stabilization of serum albumin and perhaps other proteins.
Positive_regulation (cause) of Positive_regulation (stabilization) of albumin in plasma associated with rheumatoid arthritis
1) Confidence 0.70 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9589803 Disease Relevance 0.22 Pain Relevance 0.18
In addition, bound fractions of oxycodone and morphine increased with increasing concentrations of both albumin and AAG.
Positive_regulation (increased) of Positive_regulation (increasing) of albumin associated with oxycodone and morphine
2) Confidence 0.50 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8249052 Disease Relevance 0 Pain Relevance 1.32
IMPLICATIONS: Sevoflurane delivered in a 3% concentration with a fresh gas flow of 1 L/min for 4 h generated an average maximal Compound A concentration of 39 ppm but did not result in any significant increase in sensitive markers of renal function or injury, including urinary protein, albumin, glucose, and alpha- and pi-glutathione-S-transferase.
Neg (not) Positive_regulation (result) of Positive_regulation (increase) of albumin associated with injury
3) Confidence 0.39 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9495434 Disease Relevance 0.33 Pain Relevance 0.37
The 66.6-kDa and 33.4-kDa peaks most likely represent serum albumin and its doubly protonated form, as they are the correct mass and they increase after response to therapy, reflective of the known rise in serum albumin levels in these patients (data not shown).
Positive_regulation (after) of Positive_regulation (increase) of albumin
4) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175022 Disease Relevance 0.47 Pain Relevance 0.23

General Comments

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