INT58118

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Context Info
Confidence 0.50
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.76
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc5a8) plasma membrane (Slc5a8) transmembrane transport (Slc5a8)
Anatomy Link Frequency
neurons 1
Slc5a8 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 20 98.68 Very High Very High Very High
Clonidine 9 98.64 Very High Very High Very High
Bioavailability 9 91.52 High High
agonist 3 87.12 High High
Kinase C 23 66.28 Quite High
imagery 6 61.12 Quite High
qutenza 17 57.44 Quite High
cINOD 9 32.08 Quite Low
Neurotransmitter 3 15.56 Low Low
Glutamate 3 14.44 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 25 98.68 Very High Very High Very High
Anxiety Disorder 3 85.16 High High
Nociception 17 79.04 Quite High
Inflammatory Bowel Disease 3 61.08 Quite High
INFLAMMATION 10 31.84 Quite Low
Diabetes Mellitus 3 30.64 Quite Low
Starvation 3 28.40 Quite Low
Cancer 126 22.32 Low Low
Apoptosis 45 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-hydroxybutyrate is transported via SLC5A8 in a Na+-dependent manner (Fig. 1a) and that this transport is inhibited competitively by other substrates of the transporter (Fig. 1b).
Positive_regulation (transported) of SLC5A8
1) Confidence 0.50 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0.04
-hydroxybutyrate are transportable substrates for SLC5A8, we were curious to find out if ?
Positive_regulation (substrates) of SLC5A8
2) Confidence 0.50 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.06 Pain Relevance 0.05
These studies show that the high-affinity sodium-coupled MCT SLC5A8 is expressed specifically in neurons in the brain, suggesting that the transporter might play an important role in the neuronal uptake of lactate and ketone bodies and thus in the maintenance of energy status of the neurons.
Positive_regulation (coupled) of SLC5A8 in neurons
3) Confidence 0.50 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0
While neither Bus 0.3 mg.kg-1 nor Clo 3 micrograms.kg-1 was effective in this model, combination of them increased AIT.
Neg (neither) Positive_regulation (increased) of AIT associated with clonidine
4) Confidence 0.07 Published 1993 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 8249634 Disease Relevance 0.22 Pain Relevance 0.76
Consistent with our results, low incidence of co-activation of menthol and AIT has been previously reported in DRG cells by others [28,32].
Positive_regulation (activation) of AIT associated with dorsal root ganglion
5) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.48 Pain Relevance 0.45

General Comments

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