INT58145

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 13.33
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
peritoneal macrophages 9
mast cell 3
cardiac myocyte 2
neurons 2
mesangial cells 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 80 100.00 Very High Very High Very High
bradykinin 1 99.70 Very High Very High Very High
Inflammation 77 99.42 Very High Very High Very High
qutenza 20 98.96 Very High Very High Very High
Morphine 12 98.96 Very High Very High Very High
Dopamine 1 98.76 Very High Very High Very High
narcan 9 97.90 Very High Very High Very High
chemokine 14 95.12 Very High Very High Very High
transdermal 1 94.16 High High
guanethidine 8 93.24 High High
Disease Link Frequency Relevance Heat
Cancer 17 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Nociception 39 99.98 Very High Very High Very High
Injury 14 99.98 Very High Very High Very High
Burns 24 99.84 Very High Very High Very High
Dehydration 14 99.74 Very High Very High Very High
Wallerian Degeneration 15 99.44 Very High Very High Very High
INFLAMMATION 84 99.42 Very High Very High Very High
Hyperalgesia 3 98.22 Very High Very High Very High
Contact Dermatitis 1 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyperalgesic responses to intraplantar (i.pl.) injections of carrageenin or bradykinin, which act by stimulating TNF-alpha release, but not responses to TNF-alpha or prostaglandin E(2), were inhibited in a dose-dependent manner by pretreatment of the animals with thalidomide.
Neg (not) Positive_regulation (stimulating) of Localization (release) of TNF-alpha associated with hyperalgesia and bradykinin
1) Confidence 0.67 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10720640 Disease Relevance 0.68 Pain Relevance 0.39
Mitogen-stimulated splenocytes had a lower production of interferon-gamma as well as an increase in the secretion of tumor necrosis factor-alpha.
Positive_regulation (increase) of Localization (secretion) of tumor necrosis factor associated with necrosis and cancer
2) Confidence 0.67 Published 1993 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 8253541 Disease Relevance 1.22 Pain Relevance 0.69
Dietary CAP had no effect on phagocytic activity by peritoneal macrophages, but the levels of secreted TNF alpha increased in the groups fed 20 ppm CAP compared to the control.
Positive_regulation (increased) of Localization (secreted) of TNF alpha in peritoneal macrophages associated with qutenza
3) Confidence 0.63 Published 1998 Journal Int J Vitam Nutr Res Section Abstract Doc Link 9565827 Disease Relevance 0.19 Pain Relevance 1.06
cis-urocanic acid induces mast cell degranulation and release of preformed TNF-alpha: A possible mechanism linking UVB and cis-urocanic acid to immunosuppression of contact hypersensitivity.
Spec (possible) Positive_regulation (induces) of Localization (release) of TNF-alpha in mast cell associated with contact dermatitis
4) Confidence 0.60 Published 1999 Journal Skin Pharmacol. Appl. Skin Physiol. Section Title Doc Link 10325580 Disease Relevance 0.38 Pain Relevance 0.13
Previous studies from this laboratory had shown that exposure of mice to cold water stress leads to an increase in the secretion of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha) from their peritoneal macrophages.
Positive_regulation (increase) of Localization (secretion) of tumor necrosis factor-alpha in peritoneal macrophages associated with necrosis, cancer and dehydration
5) Confidence 0.50 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.70 Pain Relevance 0.15
RESULTS: Morphine alone did not enhance the generation of TNF-alpha by mesangial cells, however, an enhanced (P < 0.001) TNF-alpha production was observed when mesangial cells were first treated with morphine for 18 h and then activated further with LPS.
Neg (not) Positive_regulation (enhance) of Localization (generation) of TNF-alpha in mesangial cells
6) Confidence 0.50 Published 2000 Journal Inflammation Section Body Doc Link 10921509 Disease Relevance 0.14 Pain Relevance 0
These cells modulate the nociceptive response induced by zymosan and acetic acid via release of tumour necrosis factor alpha (TNF-alpha), interleukin 1beta and interleukin 8.
Positive_regulation (induced) of Localization (release) of TNF-alpha associated with nociception, necrosis and cancer
7) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.89 Pain Relevance 0.07
In conclusion, our results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleukin 8 by resident peritoneal macrophages and mast cells.
Positive_regulation (due) of Localization (release) of TNF-alpha in peritoneal macrophages associated with nociception
8) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.70 Pain Relevance 0.09
Burn trauma promoted cardiac myocyte secretion of tumor necrosis factor (TNFalpha) (175+/-6 pg/mL) compared to that measured in shams (72+/-9 pg/mL, P < 0.05); burn trauma also increased cardiac myocyte secretion of interleukin 1beta (IL-1beta) (sham: 2+/-0.5; burn: 22+/-1 pg/mL, P < 0.05) and IL-6 (sham: 70+/-6; burn: 148+/-16 pg/mL, P < 0.05).
Positive_regulation (promoted) of Localization (secretion) of TNFalpha in cardiac myocyte associated with necrosis, cancer, burns and injury
9) Confidence 0.48 Published 2001 Journal Shock Section Abstract Doc Link 11508864 Disease Relevance 2.28 Pain Relevance 0.03
TNFalpha and IL-1alpha protein synthesis and secretion were rapidly upregulated during rapid-WD in Schwann cells.
Positive_regulation (upregulated) of Localization (secretion) of TNFalpha in Schwann cells associated with wallerian degeneration
10) Confidence 0.47 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.46 Pain Relevance 0.30
Budlein A also inhibited the carrageenan-induced release of TNF-alpha (52%), KC (70%) and IL-1beta (59%).
Positive_regulation (carrageenan-induced) of Localization (release) of TNF-alpha
11) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.70 Pain Relevance 0.47
Pretreatment of cultures with naloxone (1 microM) followed by treatment with lipopolysaccharide significantly inhibited the lipopolysaccharide-induced production of nitric oxide and the release of tumor necrosis factor-alpha, and significantly reduced the lipopolysaccharide-induced damage to neurons.
Positive_regulation (induced) of Localization (release) of tumor necrosis factor-alpha in neurons associated with necrosis, cancer and narcan
12) Confidence 0.46 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842020 Disease Relevance 0.41 Pain Relevance 0.52
Previous studies from this laboratory had shown that exposure of mice to cold water stress leads to an increase in the secretion of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF alpha) from their peritoneal macrophages.
Positive_regulation (increase) of Localization (secretion) of TNF alpha in peritoneal macrophages associated with necrosis, cancer and dehydration
13) Confidence 0.36 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8642417 Disease Relevance 0.70 Pain Relevance 0.15
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Neg (not) Positive_regulation (induced) of Localization (release) of TNF-alpha
14) Confidence 0.35 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Together, these results suggest that inflammation associated with an adaptive immune response induces hypernociception that is mediated by an initial release of TNF-alpha, which triggers the subsequent release of IL-1beta and KC/CXCL1.
Positive_regulation (triggers) of Localization (release) of TNF-alpha associated with inflammation
15) Confidence 0.35 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.17 Pain Relevance 0.22
Consistently, antigen challenge induced a time-dependent release of TNF-alpha, IL-1beta and KC/CXCL-1 in IM, but not in SI, mice.
Positive_regulation (time-dependent) of Localization (release) of TNF-alpha
16) Confidence 0.35 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.23
Together, these results suggest that inflammation associated with an adaptive immune response induces hypernociception that is mediated by an initial release of TNF-alpha, which triggers the subsequent release of IL-1beta and KC/CXCL1.
Positive_regulation (mediated) of Localization (release) of TNF-alpha associated with inflammation
17) Confidence 0.35 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.17 Pain Relevance 0.23
Of note, the abolition of NOx release may also reflect the fact that the exasperated inflammation due to the lack of iNOS may trigger the release of cytokines (including TNFalpha) down-regulating the expression of eNOS [40].
Positive_regulation (trigger) of Localization (release) of TNFalpha associated with inflammation and cytokine
18) Confidence 0.32 Published 2010 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2796899 Disease Relevance 0.62 Pain Relevance 0.18
Plant extracts were initially tested against LPS-stimulated release of tumor necrosis factor alpha (TNF-?)
Positive_regulation (stimulated) of Localization (release) of tumor necrosis factor alpha associated with necrosis and cancer
19) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2995738 Disease Relevance 0.45 Pain Relevance 0.20
In conclusion, our results suggest that the nociceptive activity of zymosan and acetic acid in the writhing model is due to the release of TNF-alpha, interleukin 1beta and interleukin 8 by resident peritoneal macrophages and mast cells.
Positive_regulation (due) of in mast cells Localization (release) of TNF-alpha in peritoneal macrophages associated with nociception
20) Confidence 0.17 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.70 Pain Relevance 0.09

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