INT58161

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Context Info
Confidence 0.37
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.58
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
signal transducer activity (Avp)
Avp (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 27 89.56 High High
Opioid 1 88.92 High High
depression 6 86.40 High High
cytokine 39 60.32 Quite High
Enkephalin 1 25.00 Low Low
Neurotransmitter 6 23.80 Low Low
Central nervous system 6 22.36 Low Low
Kinase C 36 5.00 Very Low Very Low Very Low
dexamethasone 27 5.00 Very Low Very Low Very Low
amygdala 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eating Disorder 3 87.28 High High
Depression 6 86.40 High High
Pituitary Acth Hypersecretion 3 85.92 High High
Hyponatremia 15 84.08 Quite High
Targeted Disruption 30 49.04 Quite Low
Volume Depletion And Dehydration 6 38.88 Quite Low
Stress 84 20.84 Low Low
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We had previously found that chronic ethanol ingestion resulted in decreased levels of hypothalamic and extrahypothalamic vasopressin mRNA, and the current study investigated the effect of ethanol ingestion on prodynorphin mRNA levels.
Positive_regulation (resulted) of Transcription (levels) of vasopressin
1) Confidence 0.37 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255170 Disease Relevance 0 Pain Relevance 0.09
It is generally accepted that cAMP is an important positive inducer of the vasopressin gene transcription.
Positive_regulation (inducer) of Transcription (transcription) of vasopressin gene
2) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.34 Pain Relevance 0.12
Precise reporter analyses using the heterologous cell lines show that cAMP stimulator also augments vasopressin gene transcription (Pardy et al. 1992; Emanuel et al. 1992).
Positive_regulation (augments) of Transcription (transcription) of vasopressin gene
3) Confidence 0.07 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.23 Pain Relevance 0.06
It is probably undeniable that the cAMP/PKA pathway activates the vasopressin and CRH gene transcription, because of the large amount of evidence attesting to it; however, the whole picture about other regulators has not yet been fully elucidated.
Positive_regulation (activates) of Transcription (transcription) of vasopressin
4) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.04

General Comments

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