INT58170

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Context Info
Confidence 0.18
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Kcne1) lysosome (Kcne1)
Anatomy Link Frequency
neuronal 1
neurons 1
external 1
OVLT 1
Kcne1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
GABAergic 3 100.00 Very High Very High Very High
halothane 8 99.98 Very High Very High Very High
Analgesic 1 99.80 Very High Very High Very High
tetrodotoxin 4 98.90 Very High Very High Very High
antagonist 5 98.68 Very High Very High Very High
gABA 4 98.28 Very High Very High Very High
Action potential 2 96.32 Very High Very High Very High
Raphe 2 95.52 Very High Very High Very High
agonist 8 94.80 High High
Substantia gelatinosa neuron 4 94.40 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of ACh esterase by donepezil (1 micromol/L from DIV 3 to DIV 14) weakly decreased M-autoreceptor function at DIV 14; inhibition of neuronal firing by 0.1 tetrodotoxin (0.1 micromol/L from DIV 3 to DIV 14) did not tend to affect M-autoreceptor function at DIV 14.
Regulation (affect) of M-autoreceptor in neuronal associated with tetrodotoxin
1) Confidence 0.18 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17472710 Disease Relevance 0 Pain Relevance 0.33
The presence of the M-agonists oxotremorine (100 micromol/L) or carbachol (100 micromol/L) from DIV 3 to DIV 14, or from DIV 13 to DIV 14, abolished M-autoreceptor function at DIV 14, whereas the presence of the M-antagonist atropine (10 micromol/L from DIV 3 to DIV 14) during growth left M-autoreceptor function unaltered.
Regulation (unaltered) of M-autoreceptor associated with antagonist and agonist
2) Confidence 0.18 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17472710 Disease Relevance 0 Pain Relevance 0.30
The halothane effect on mIPSC and mEPSC frequency was dependent on the external calcium concentration.
Regulation (effect) of mIPSC in external associated with halothane
3) Confidence 0.15 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490587 Disease Relevance 0 Pain Relevance 0.63
The above-mentioned results show that ET plays anesthetic or analgesic roles by modulating the decay time of GABAergic mIPSC, i.e. by prolonging the mean open time of GABA(A) receptors, however, ET has no direct effect on local excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Regulation (modulating) of GABAergic mIPSC in neurons associated with gaba, gabaergic, analgesic, substantia gelatinosa neuron and spinal cord
4) Confidence 0.07 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15224160 Disease Relevance 0 Pain Relevance 0.62
By 4 h, these message levels still were elevated in the OVLT and rPOA and they now also were significantly higher than control values in the mPOA and cPOA.
Regulation (values) of mPOA in OVLT
5) Confidence 0.00 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255183 Disease Relevance 0 Pain Relevance 0.31

General Comments

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