INT58173

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 1.00
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Homer1) cytoplasm (Homer1)
Anatomy Link Frequency
hypothalamus 1
piriform cortex 1
Homer1 (Mus musculus)
Pain Link Frequency Relevance Heat
anticonvulsant 12 99.50 Very High Very High Very High
narcan 3 98.08 Very High Very High Very High
Enkephalin 8 96.96 Very High Very High Very High
Hippocampus 51 96.88 Very High Very High Very High
antagonist 11 86.56 High High
opioid receptor 3 84.60 Quite High
MU agonist 3 84.16 Quite High
Nerve growth factor 3 79.00 Quite High
agonist 3 76.40 Quite High
Dynorphin 4 75.32 Quite High
Disease Link Frequency Relevance Heat
Convulsion 13 89.76 High High
Anxiety Disorder 145 71.72 Quite High
Shock 75 5.00 Very Low Very Low Very Low
Targeted Disruption 20 5.00 Very Low Very Low Very Low
Diphtheria 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low
Schizophrenia 5 5.00 Very Low Very Low Very Low
Nociception 5 5.00 Very Low Very Low Very Low
Depression 5 5.00 Very Low Very Low Very Low
Stress 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vesl-1 gene encodes three isoforms, which include Vesl-1S/Homer-1a, Vesl-1M/Ania-3, and Vesl-1L/Homer-1c, in mice (Figure 1) [11,12].
Negative_regulation (include) of Vesl-1S
1) Confidence 0.43 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.06
Pre-treatment with the anticonvulsant agent enadoline (3 mg/kg), given at an anticonvulsant dose, did not result in reduced immediate early gene messenger RNA levels.
Negative_regulation (reduced) of immediate early gene messenger RNA associated with anticonvulsant
2) Confidence 0.40 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.06 Pain Relevance 0.39
Pre-treatment (30 min prior to N-methyl-DL-aspartate) with the anticonvulsant drugs dizocilpine maleate (1 mg/kg) and HA 966 (200 micrograms, i.c.v.) resulted in significantly reduced immediate early gene messenger RNA levels in the hypothalamus and piriform cortex, and attenuated levels in the hippocampus.
Negative_regulation (reduced) of immediate early gene messenger RNA in hypothalamus associated with hippocampus and anticonvulsant
3) Confidence 0.40 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.07 Pain Relevance 0.37
The vesl-1 gene encodes three isoforms, which include Vesl-1S/Homer-1a, Vesl-1M/Ania-3, and Vesl-1L/Homer-1c, in mice (Figure 1) [11,12].
Negative_regulation (include) of Vesl-1L
4) Confidence 0.37 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.07
The vesl-1 gene encodes three isoforms, which include Vesl-1S/Homer-1a, Vesl-1M/Ania-3, and Vesl-1L/Homer-1c, in mice (Figure 1) [11,12].
Negative_regulation (include) of Homer-1a
5) Confidence 0.19 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.06
The vesl-1 gene encodes three isoforms, which include Vesl-1S/Homer-1a, Vesl-1M/Ania-3, and Vesl-1L/Homer-1c, in mice (Figure 1) [11,12].
Negative_regulation (include) of Vesl-1M
6) Confidence 0.19 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.07
The vesl-1 gene encodes three isoforms, which include Vesl-1S/Homer-1a, Vesl-1M/Ania-3, and Vesl-1L/Homer-1c, in mice (Figure 1) [11,12].
Negative_regulation (include) of Homer-1c
7) Confidence 0.16 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.16 Pain Relevance 0.07
Pre-treatment (30 min prior to N-methyl-DL-aspartate) with the anticonvulsant drugs dizocilpine maleate (1 mg/kg) and HA 966 (200 micrograms, i.c.v.) resulted in significantly reduced immediate early gene messenger RNA levels in the hypothalamus and piriform cortex, and attenuated levels in the hippocampus.
Negative_regulation (reduced) of immediate early gene messenger RNA in piriform cortex associated with hippocampus and anticonvulsant
8) Confidence 0.14 Published 1993 Journal Neuroscience Section Abstract Doc Link 8255428 Disease Relevance 0.07 Pain Relevance 0.37
Naloxone reversed such behavioral recovery (i.e. reinstated akinesia), but did not significantly affect suppressed immediate-early gene induction.
Neg (not) Negative_regulation (suppressed) of immediate-early gene associated with narcan
9) Confidence 0.02 Published 1999 Journal Neuroscience Section Abstract Doc Link 10363818 Disease Relevance 0 Pain Relevance 1.33

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