INT58184

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.58
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga3) plasma membrane (Itga3)
Anatomy Link Frequency
acinar cells 4
extracellular matrix 2
4T1 1
Itga3 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 97.48 Very High Very High Very High
Inflammation 9 92.88 High High
metalloproteinase 3 78.32 Quite High
cytokine 6 22.88 Low Low
imagery 12 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 18 100.00 Very High Very High Very High
Pancreatic Cancer 24 99.76 Very High Very High Very High
Adenocarcinoma 8 99.00 Very High Very High Very High
Cancer 90 98.08 Very High Very High Very High
Pancreatitis 8 97.48 Very High Very High Very High
Metastasis 77 93.76 High High
INFLAMMATION 10 92.88 High High
Apoptosis 1 90.80 High High
Death 4 69.68 Quite High
Hematological Disease 11 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated expression of genes associated with tight junctions (Cldn3, Cldn4, Cldn7 and Tjp2), adherins junctions (Cdh1 and Vil1) focal adhesions (Itga3, Itga6 and Lama5), and intermediate filaments (Krt1-18 and Krt2-7) indicate that the 4T1 line has greater epithelial character than the non-metastatic lines.
Gene_expression (expression) of Itga3 in 4T1 associated with adhesions
1) Confidence 0.38 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.87 Pain Relevance 0.15
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, whereas centroacinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
2) Confidence 0.25 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.73 Pain Relevance 0.09
Expression of VLA alpha 3 and VLA alpha 5 in pancreatic carcinoma was heterogeneous, ranging from moderate to weak and lost in about 50% of the cells.
Gene_expression (Expression) of VLA alpha associated with pancreatic cancer
3) Confidence 0.25 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.76 Pain Relevance 0.08
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, whereas centroacinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
4) Confidence 0.25 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.72 Pain Relevance 0.09
Expression of VLA alpha 3 and VLA alpha 5 in pancreatic carcinoma was heterogeneous, ranging from moderate to weak and lost in about 50% of the cells.
Gene_expression (Expression) of VLA alpha associated with pancreatic cancer
5) Confidence 0.25 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.76 Pain Relevance 0.08
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, whereas centroacinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
6) Confidence 0.25 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.69 Pain Relevance 0.10
This redistribution of VLA alpha 2 and VLA alpha 6 may reflect a loss of spatial arrangement of tumor cells and their ability to randomly interact with extracellular matrix structures during invasion and metastasis.
Gene_expression (redistribution) of VLA alpha in extracellular matrix associated with cancer and metastasis
7) Confidence 0.21 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.68 Pain Relevance 0.06
Immunohistochemically, VLA alpha 2 and VLA alpha 6 were moderately to strongly expressed on the basal surface of ductal and acinar cells in normal pancreatic tissue, whereas centroacinar cells predominantly expressed VLA alpha 3 and VLA alpha 5.
Gene_expression (expressed) of VLA alpha in acinar cells
8) Confidence 0.21 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.69 Pain Relevance 0.10
This redistribution of VLA alpha 2 and VLA alpha 6 may reflect a loss of spatial arrangement of tumor cells and their ability to randomly interact with extracellular matrix structures during invasion and metastasis.
Gene_expression (redistribution) of VLA alpha in extracellular matrix associated with cancer and metastasis
9) Confidence 0.21 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.68 Pain Relevance 0.06

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