INT58186

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.00
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGA1) plasma membrane (ITGA1)
Anatomy Link Frequency
monocytes 3
lymphocytes 2
mononuclear cells 2
stromal cells 1
pancreas 1
ITGA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 98.40 Very High Very High Very High
carpal tunnel syndrome 30 97.00 Very High Very High Very High
Inflammation 6 87.28 High High
Opioid 1 76.24 Quite High
Enkephalin 4 60.16 Quite High
superficial lamina 5 58.44 Quite High
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 2 98.40 Very High Very High Very High
Carpal Tunnel Syndrome 42 98.00 Very High Very High Very High
Adenocarcinoma 2 96.64 Very High Very High Very High
Adhesions 19 95.68 Very High Very High Very High
Cancer 36 95.08 Very High Very High Very High
Metastasis 7 94.32 High High
Amyloidosis 6 90.24 High High
Alzheimer's Dementia 6 88.28 High High
INFLAMMATION 8 87.28 High High
Pancreatic Cancer 7 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our separate study, we had generated cell type-specific transcriptomes for prostate CD26+ luminal cells, CD104+ basal cells, CD49a+ stromal cells, and CD31+ endothelial cells through cell sorting and DNA array analysis (unpublished).
Gene_expression (stromal cells) of CD49a in stromal cells
1) Confidence 0.25 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0 Pain Relevance 0.17
However, the quantitative expression of VLA-4 was not affected by treatment of PBL with any of the NSAIDs studied.
Gene_expression (expression) of VLA-4 in PBL
2) Confidence 0.22 Published 1998 Journal Arthritis Rheum. Section Body Doc Link 9751102 Disease Relevance 0 Pain Relevance 0
Expression of VLA-4 on peripheral mononuclear cells in patients on chronic haemodialysis with carpal tunnel syndrome.
Gene_expression (Expression) of VLA-4 in mononuclear cells associated with carpal tunnel syndrome
3) Confidence 0.12 Published 1998 Journal Nephrol. Dial. Transplant. Section Title Doc Link 9870477 Disease Relevance 0.89 Pain Relevance 0.50
RESULTS: The expression of VLA-4 on peripheral lymphocytes was not different among the groups.
Gene_expression (expression) of VLA-4 in lymphocytes
4) Confidence 0.12 Published 1998 Journal Nephrol. Dial. Transplant. Section Body Doc Link 9870477 Disease Relevance 0.17 Pain Relevance 0
METHODS: We compared the expression of very late activation antigen (VLA-4) on PBMC by flow cytometry in 14 patients on haemodialysis (6-21 years) with CTS, nine on haemodialysis (1-6 years) but without CTS and six patients on chronic ambulatory peritoneal dialysis (CAPD, 1-5 years) without CTS.
Gene_expression (expression) of VLA-4 in PBMC
5) Confidence 0.12 Published 1998 Journal Nephrol. Dial. Transplant. Section Body Doc Link 9870477 Disease Relevance 0.19 Pain Relevance 0
However, the FACScan fluorescence histogram of VLA-4 expression on peripheral monocytes showed a bimodal pattern in the CTS group, and the rate of the high intensity portion of the expressed VLA-4 on monocytes was significantly higher in CTS than other groups (P<0.05).
Gene_expression (expressed) of VLA-4 in monocytes
6) Confidence 0.12 Published 1998 Journal Nephrol. Dial. Transplant. Section Body Doc Link 9870477 Disease Relevance 0.15 Pain Relevance 0
However, the FACScan fluorescence histogram of VLA-4 expression on peripheral monocytes showed a bimodal pattern in the CTS group, and the rate of the high intensity portion of the expressed VLA-4 on monocytes was significantly higher in CTS than other groups (P<0.05).
Gene_expression (expression) of VLA-4 in monocytes
7) Confidence 0.12 Published 1998 Journal Nephrol. Dial. Transplant. Section Body Doc Link 9870477 Disease Relevance 0.16 Pain Relevance 0
CONCLUSION: Our results suggest that increased expression of VLA-4 on peripheral monocytes and augmented adhesion capacity of PBMC to fibronectin may be involved in the development of CTS in haemodialysis patients.


Gene_expression (expression) of VLA-4 in monocytes
8) Confidence 0.09 Published 1998 Journal Nephrol. Dial. Transplant. Section Body Doc Link 9870477 Disease Relevance 0.12 Pain Relevance 0
Expression and distribution of VLA receptors in the pancreas: an immunohistochemical study.
Gene_expression (Expression) of VLA in pancreas
9) Confidence 0.03 Published 1993 Journal Pancreas Section Title Doc Link 8255885 Disease Relevance 0.63 Pain Relevance 0.08
Using immunohistochemistry [the alkaline phosphatase-anti-alkaline phosphatase (APAAP) technique] we compared the expression and distribution of VLA receptors in normal pancreatic tissue, chronic pancreatitis, and ductal pancreatic adenocarcinoma.
Gene_expression (expression) of VLA associated with adenocarcinoma and chronic pancreatitis
10) Confidence 0.02 Published 1993 Journal Pancreas Section Abstract Doc Link 8255885 Disease Relevance 0.68 Pain Relevance 0.10

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