INT5819

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2009
Negated 13
Speculated 8
Reported most in Abstract
Documents 64
Total Number 73
Disease Relevance 6.69
Pain Relevance 57.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
spinal cord 18
spinal 16
brain 6
hearts 4
body 4
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 436 100.00 Very High Very High Very High
Spinal cord 94 100.00 Very High Very High Very High
Morphine 49 100.00 Very High Very High Very High
Dynorphin 40 100.00 Very High Very High Very High
agonist 40 100.00 Very High Very High Very High
antinociception 39 100.00 Very High Very High Very High
medulla 37 100.00 Very High Very High Very High
gABA 37 100.00 Very High Very High Very High
tail-flick 23 100.00 Very High Very High Very High
ischemia 20 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 20 100.00 Very High Very High Very High
Urological Neuroanatomy 12 100.00 Very High Very High Very High
Natriuresis 2 100.00 Very High Very High Very High
Heart Rate Under Development 1 100.00 Very High Very High Very High
Hypoxia 9 99.98 Very High Very High Very High
Injury 11 99.52 Very High Very High Very High
Chorea 1 99.40 Very High Very High Very High
Necrosis 6 97.36 Very High Very High Very High
Cancer 8 97.00 Very High Very High Very High
Bordatella Infection 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of ischemia on cardiac Leucine enkephalin (Leu-enk) content, degradation and coronary release was studied in the isolated perfused hearts of male Sprague Dawley rats.
Regulation (effect) of Localization (release) of enkephalin in hearts associated with ischemia and enkephalin
1) Confidence 0.62 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.32 Pain Relevance 0.41
With the addition of thiorphan (10(-5) M), though there was no effect on the resting release of either Enk or X-Enk, the levels of Enk measured under evoked conditions were significantly augmented in both ventricular and spinal perfusates.
Neg (no) Regulation (effect) of Localization (release) of X-Enk in spinal associated with enkephalin
2) Confidence 0.62 Published 1990 Journal Peptides Section Abstract Doc Link 2087436 Disease Relevance 0 Pain Relevance 1.59
The present investigations, at two different spinal/medullary levels (viz. cervicotrigeminal and lumbar) demonstrate that, in the rat, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from neural segments related to the stimulated area of the body, but does increase its release from other segments.
Neg (not) Regulation (alter) of Localization (release) of Met-enkephalin-like in body associated with enkephalin
3) Confidence 0.61 Published 1987 Journal Brain Res. Section Abstract Doc Link 3828785 Disease Relevance 0.16 Pain Relevance 0.80
The role of gonadal steroids in the control of Met-ENK release in vitro was also examined.
Regulation (control) of Localization (release) of Met-ENK in gonadal
4) Confidence 0.60 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.52
However, in vitro studies using slices of the dorsal zone of the rat lumbar cord did not reveal any stimulatory effect of 5-HT on the spontaneous or K+-evoked release of met-enkephalin (fig. 4).
Regulation (effect) of Localization (release) of enkephalin in dorsal associated with enkephalin
5) Confidence 0.60 Published 1985 Journal J Pharmacol Section Abstract Doc Link 2993751 Disease Relevance 0.15 Pain Relevance 0.38
To determine whether such opioid stimulatory effects may be mediated directly in the pallidum, in vivo microdialysis was used to study the effects of local administration of several concentrations of the mu receptor agonists morphine and morphine-6-glucuronide (M6G) as well as the the delta receptor agonist SNC80 on pallidal enkephalin release in freely moving rats.
Regulation (effects) of Localization (release) of enkephalin in pallidum associated with agonist, enkephalin, opioid and morphine
6) Confidence 0.60 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618438 Disease Relevance 0 Pain Relevance 1.36
Opioid regulation of pallidal enkephalin release: bimodal effects of locally administered mu and delta opioid agonists in freely moving rats.
Regulation (regulation) of Localization (release) of enkephalin associated with mu agonist, enkephalin and opioid
7) Confidence 0.60 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9618438 Disease Relevance 0 Pain Relevance 1.38
Hypoxia influences enkephalin release in rats.
Regulation (influences) of Localization (release) of enkephalin associated with hypoxia and enkephalin
8) Confidence 0.60 Published 2000 Journal Neuroreport Section Title Doc Link 10841376 Disease Relevance 0.69 Pain Relevance 0.31
It was found that the basal and CRH-induced release of Met-ENK was not changed 1 week after castration.
Neg (not) Regulation (changed) of Localization (release) of Met-ENK
9) Confidence 0.53 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.50
This study examined several in vivo and in vitro factors which influence the release of [Met5]-enkephalin (Met-ENK) from male rat hypothalamic slices superfused in vitro.
Regulation (influence) of Localization (release) of Met-ENK associated with enkephalin
10) Confidence 0.53 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2783452 Disease Relevance 0 Pain Relevance 0.43
Presynaptic opioid kappa-receptor and regulation of the release of Met-enkephalin in the rat brainstem.
Regulation (regulation) of Localization (release) of Met-enkephalin in brainstem associated with medulla, analgesic, enkephalin and opioid
11) Confidence 0.48 Published 1987 Journal Neurosci. Lett. Section Title Doc Link 2829060 Disease Relevance 0 Pain Relevance 1.13
With the addition of thiorphan (10(-5) M), though there was no effect on the resting release of either Enk or X-Enk, the levels of Enk measured under evoked conditions were significantly augmented in both ventricular and spinal perfusates.
Neg (no) Regulation (effect) of Localization (release) of Enk in spinal associated with enkephalin
12) Confidence 0.45 Published 1990 Journal Peptides Section Abstract Doc Link 2087436 Disease Relevance 0 Pain Relevance 1.59
These cytokines also regulate the secretion of proenkephalin-derived peptides from astrocytes.
Regulation (regulate) of Localization (secretion) of proenkephalin in astrocytes associated with cytokine
13) Confidence 0.45 Published 1992 Journal Endocrinology Section Abstract Doc Link 1396335 Disease Relevance 0.98 Pain Relevance 0.33
The nucleus reticularis gigantocellularis of the rat medulla oblongata was perfused in situ, and effects of noxious stimuli on the release of immunoreactive Met-enkephalin were examined.
Regulation (effects) of in nucleus Localization (release) of Met-enkephalin in medulla oblongata associated with medulla and enkephalin
14) Confidence 0.45 Published 1984 Journal Brain Res. Bull. Section Abstract Doc Link 6713210 Disease Relevance 0 Pain Relevance 0.45
To ensure dopamine regulation of enkephalin secretion, shorter dopaminergic treatments were performed.
Regulation (regulation) of Localization (secretion) of enkephalin associated with dopamine and enkephalin
15) Confidence 0.45 Published 1993 Journal Neuroscience Section Abstract Doc Link 8487949 Disease Relevance 0 Pain Relevance 1.28
This effect of dopamine on the KCl-induced methionine enkephalin secretion was mimicked by bromocriptine (10(-6) M), reversed by sulpiride (10(-6) M) and unaffected by the D1 antagonist SCH 23390 (10(-6) M) application onto striatal neurons.
Neg (unaffected) Regulation (unaffected) of Localization (secretion) of enkephalin in neurons associated with dopamine, antagonist and enkephalin
16) Confidence 0.45 Published 1993 Journal Neuroscience Section Abstract Doc Link 8487949 Disease Relevance 0 Pain Relevance 1.21
Effects of DSIP on Met-ENK release in other discrete brain regions were also studied.
Regulation (Effects) of Localization (release) of Met-ENK in brain
17) Confidence 0.45 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1861139 Disease Relevance 0 Pain Relevance 0.48
Taken together, these data suggest that regulatable release of enkephalin from transplanted cells near the spinal dorsal horn was able to reverse the development of chronic neuropathic pain.
Regulation (regulatable) of Localization (release) of enkephalin in dorsal horn associated with spinal dorsal horn, neuropathic pain and enkephalin
18) Confidence 0.44 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17904399 Disease Relevance 0.55 Pain Relevance 1.02
The results showed that the secretion of enkephalin from IASL/hPPE cells could be switched on and off under the regulation of doxycycline in a dose-dependent manner.
Regulation (regulation) of Localization (secretion) of enkephalin associated with enkephalin
19) Confidence 0.44 Published 2008 Journal Eur J Pain Section Abstract Doc Link 17904399 Disease Relevance 0.72 Pain Relevance 1.04
The effect of ischemia on cardiac Leucine enkephalin (Leu-enk) content, degradation and coronary release was studied in the isolated perfused hearts of male Sprague Dawley rats.
Regulation (effect) of Localization (release) of enk in hearts associated with ischemia and enkephalin
20) Confidence 0.44 Published 2001 Journal Arch. Physiol. Biochem. Section Abstract Doc Link 11471067 Disease Relevance 0.32 Pain Relevance 0.41

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