INT58203

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HOMER2) cytoplasm (HOMER2)
Anatomy Link Frequency
neurons 1
striatum 1
pole 1
HOMER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 100.00 Very High Very High Very High
substance P 4 99.04 Very High Very High Very High
cerebral cortex 4 97.68 Very High Very High Very High
antagonist 12 92.40 High High
Neuropeptide 3 90.00 High High
GABAergic 6 88.40 High High
agonist 3 86.20 High High
tetrodotoxin 3 77.28 Quite High
excitatory amino acid 2 75.92 Quite High
Action potential 9 74.88 Quite High
Disease Link Frequency Relevance Heat
Unconsciousness 6 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Amnesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This provides the first direct pharmacological evidence for a functional role of ACPD-sensitive receptors in central neurotransmission, and indicates that these receptors may play an important part in central sensory processes.
Positive_regulation (role) of ACPD
1) Confidence 0.49 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8261098 Disease Relevance 0 Pain Relevance 0.16
Activation of metabotropic glutamate receptors (mGluRs) with (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) elicited in the frontal or occipital pole of the intact cerebral cortex preparation of the newborn mouse (P0-P3) a transient oscillatory field potential activity in the frequency range of 11-14Hz.
Positive_regulation (Activation) of ACPD in pole associated with glutamate receptor and cerebral cortex
2) Confidence 0.15 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16876205 Disease Relevance 0 Pain Relevance 0.35
However, intrastriatal ACPD (0.8, 4, 20 and 100 nmol) dose-dependently elevated preprodynorphin (PPD), substance P (SP) and preproenkephalin (PPE) mRNA expression in the dorsal striatum as revealed by quantitative in situ hybridization.
Positive_regulation (elevated) of ACPD in striatum associated with substance p
3) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555048 Disease Relevance 0 Pain Relevance 0.48
In brain slices, however, these neurons generally do not fire spontaneously; a sustained single spike firing pattern can be induced by pharmacological activation of metabotropic glutamate receptors (mGluRs) with trans-ACPD [63].
Positive_regulation (activation) of trans-ACPD in neurons associated with glutamate receptor
4) Confidence 0.02 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074352 Disease Relevance 0 Pain Relevance 0.17

General Comments

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