INT58208

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Context Info
Confidence 0.53
First Reported 1993
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 3.49
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsl) histone binding (Ctsl) nucleolus (Ctsl)
vacuole (Ctsl) lysosome (Ctsl) cytoplasm (Ctsl)
Anatomy Link Frequency
cartilage 1
vesicle 1
Ctsl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 93 100.00 Very High Very High Very High
cINOD 4 98.96 Very High Very High Very High
tetrodotoxin 3 98.28 Very High Very High Very High
Abeta 8 97.32 Very High Very High Very High
Neuropeptide 4 93.76 High High
Inflammation 34 90.64 High High
anesthesia 7 90.28 High High
metalloproteinase 89 86.64 High High
Neurotransmitter 3 85.00 Quite High
Enkephalin 1 70.32 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 93 100.00 Very High Very High Very High
Severe Combined Immunodeficiency 8 100.00 Very High Very High Very High
INFLAMMATION 40 98.84 Very High Very High Very High
Paraparesis 3 98.64 Very High Very High Very High
Pressure Volume 2 Under Development 6 94.28 High High
Alzheimer's Dementia 3 89.60 High High
Quadriplegia 6 87.12 High High
Death 3 85.08 High High
Scoliosis 6 83.60 Quite High
Cancer 21 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the non-steroidal anti-inflammatory drugs tested, phenylbutazone was found to be most potent inhibitor of cathepsin L activity.
Negative_regulation (inhibitor) of cathepsin L associated with inflammation and cinod
1) Confidence 0.53 Published 1993 Journal Indian J. Med. Res. Section Abstract Doc Link 8262580 Disease Relevance 0.43 Pain Relevance 0.38
RESULTS: There was significant reduction of the MIP MEP and PEF values at 24 and 48 hours post-operative compared to the pre-operative values.
Negative_regulation (reduction) of MEP
2) Confidence 0.42 Published 2009 Journal Acta Gastroenterol. Latinoam. Section Body Doc Link 19408738 Disease Relevance 0.08 Pain Relevance 0
One out of four patients with concomitant loss of TcMEP and SSEP data awoke with a dense paraparesis without significant recovery at three months.
Negative_regulation (loss) of TcMEP associated with paraparesis
3) Confidence 0.24 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857496 Disease Relevance 0.54 Pain Relevance 0
Inhalation of 66% nitrous oxide did not prolong latency, but significantly reduced the amplitude of MEP.
Neg (not) Negative_regulation (reduced) of MEP
4) Confidence 0.21 Published 2002 Journal Masui Section Abstract Doc Link 12481449 Disease Relevance 0 Pain Relevance 0.09
Another recent abstract reported on 12 out of 427 cases (2.8%) that had an intraoperative loss of transcranial motor-evoked potentials (TcMEP) and/or SSEP data10.
Negative_regulation (loss) of TcMEP
5) Confidence 0.18 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857496 Disease Relevance 0.56 Pain Relevance 0
However, one out of eight patients with loss of TcMEP data with maintained SSEP data had transient postoperative weakness, which resolved within one week.
Negative_regulation (loss) of TcMEP
6) Confidence 0.18 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857496 Disease Relevance 0.53 Pain Relevance 0
In this review, evidence for secretory vesicle cathepsin L and Arg/Lys aminopeptidase as a distinct proteolytic pathway for processing the prohormone proenkephalin is presented.
Negative_regulation (presented) of cathepsin L in vesicle
7) Confidence 0.11 Published 2004 Journal Biol. Chem. Section Abstract Doc Link 15255178 Disease Relevance 0 Pain Relevance 0.23
In this regard, inhibition of cathepsin L by a specific ribozyme was able to reduce expression of cathepsin L mRNA to 44% [84].
Negative_regulation (inhibition) of cathepsin L
8) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.35 Pain Relevance 0.17
Cathepsin L mediated cartilage destruction in the SCID mouse model for RA could be reduced by specific ribozymes inhibiting the translation of cathepsin L mRNA into active protein [20].
Negative_regulation (reduced) of Cathepsin L in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
9) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.78 Pain Relevance 0.42
In contrast, pharmacological inhibition of cathepsin L (catL) selectively elevated Abeta42 levels but not Abeta40 or total Abeta.
Negative_regulation (inhibition) of cathepsin L associated with abeta
10) Confidence 0.02 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19064719 Disease Relevance 0.23 Pain Relevance 0.61

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