INT58210

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 5.63
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) Golgi apparatus (Pcsk1)
Anatomy Link Frequency
PC-3 5
fat 1
Odontoblasts 1
brain 1
pituitary 1
Pcsk1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 66 99.64 Very High Very High Very High
cytokine 18 94.76 High High
Pain 19 92.92 High High
Opioid 8 92.36 High High
Dynorphin 27 88.00 High High
Neuropeptide 5 87.16 High High
Calcium channel 1 85.28 High High
medulla 28 83.48 Quite High
Enkephalin 16 59.68 Quite High
imagery 35 52.76 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 143 99.78 Very High Very High Very High
Cancer 455 99.76 Very High Very High Very High
Pox Virus Infection 1 99.44 Very High Very High Very High
Osteoporosis 138 95.72 Very High Very High Very High
Pain 19 92.92 High High
Hypercalcemia 94 92.16 High High
Prostate Cancer 47 91.88 High High
Metastasis 235 88.84 High High
Obesity 61 78.56 Quite High
Targeted Disruption 14 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analyses of timed digestions showed that both mouse PC1 and PC2 were able to produce a variety of large and intermediate sized-peptides from wild-type PE as well as from the precursors mutated at initial blockade sites.
Gene_expression (produce) of PC1
1) Confidence 0.70 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 14622118 Disease Relevance 0 Pain Relevance 0.07
In this report we have addressed the mechanism of this unexpected finding by directly examining the expression of the major precursor processing endoproteases, prohormone convertases PC1 and PC2 in Cpe(fat) mice.
Spec (examining) Gene_expression (expression) of PC1 in fat
2) Confidence 0.67 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11038363 Disease Relevance 0.15 Pain Relevance 0.11
Among the prohormone convertases (PCs), PC1 and PC2 are expressed widely in neuroendocrine tissues and have been proposed to be the major convertases involved in the biosynthesis of hormonal and neural peptides.
Gene_expression (expressed) of PC1 in neural
3) Confidence 0.63 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.29
We found that the levels of PC1 and PC2 are differentially altered in a number of brain regions and in the pituitary.
Gene_expression (levels) of PC1 in brain
4) Confidence 0.52 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11038363 Disease Relevance 0.15 Pain Relevance 0.12
Odontoblasts in vitro express tubulin, inversin, rootletin, OFD1, BBS4, BBS6, ALMS1, KIF3A, PC1, and PC2.
Gene_expression (express) of PC1 in Odontoblasts
5) Confidence 0.52 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19783798 Disease Relevance 0.09 Pain Relevance 0.14
The disruption of the PC2 gene does not lead to compensatory up-regulation in the levels of other convertases with similar substrate specificity because we find no significant changes in the levels of PC1, PC5/PC6, or furin in these mice as compared with wild-type mice.
Gene_expression (levels) of PC1
6) Confidence 0.48 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10987860 Disease Relevance 0 Pain Relevance 0.41
PC1 alone is expressed in the pituitary corticotrophs and cleaves POMC, producing the NH2-terminal peptide (NT), joining peptide (JP), ACTH, ?
Gene_expression (expressed) of PC1 in corticotrophs
7) Confidence 0.38 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0 Pain Relevance 0.08
Our preliminary studies demonstrate that IL-6 expression by PC3, a line of hormone refractory prostate cancer cells is in part regulated by ERK signal transduction pathway (Koul et al in press]
Gene_expression (expression) of PC3 associated with reprotox - general 1
8) Confidence 0.13 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.57 Pain Relevance 0.03
The PC-3 cells were found to produce the lymphangiogenic growth factor VEGF-C, as determined by Northern (Figure 4A) and Western blotting (Figure 4B).
Gene_expression (produce) of PC-3 in PC-3
9) Confidence 0.11 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2294135 Disease Relevance 0.84 Pain Relevance 0
In contrast, osteolytic CaM cell lines express BMP-2 and -4, while the osteolytic CaP cell line PC-3 expresses BMP-3 [17], [47].
Gene_expression (expresses) of PC-3 in PC-3 associated with cancer and reprotox - general 1
10) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.95 Pain Relevance 0.09
The human osteolytic CaP cell line PC-3, constitutively expressing the BMP antagonist noggin [17], was first transfected with a luciferase-encoding vector to generate luc-positive clones.
Gene_expression (expressing) of PC-3 in PC-3 associated with antagonist and reprotox - general 1
11) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 0.79 Pain Relevance 0.10
Cell proliferation and expression of osteotropic factors of the Noggin-silenced PC-3/Fluc cells in vitro
Gene_expression (expression) of PC-3 in PC-3
12) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 0.20 Pain Relevance 0.05
A cell clone, PC-3/Fluc, was selected based on stable luc expression and on gene expression profile in vitro, tumor take and bone reaction after intra-osseous inoculation in vivo equivalent to those of the parental PC-3 cells (Figure S1).
Gene_expression (expression) of PC-3 in PC-3 associated with cancer
13) Confidence 0.01 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 0.72 Pain Relevance 0.09
Where NEC needed to be co-expressed, the MEF cells were co-transfected with NEC 24 hrs prior to the cell harvesting.
Gene_expression (expressed) of NEC
14) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.06 Pain Relevance 0.03
Recombinant vaccinia virus vectors were used to coexpress mouse prohormone convertase 1 (mPC1), mPC2, or human furin together with human proenkephalin in GH4C1 cells (rat pituitary somatomammotrophs) to examine the proteolytic processing of proenkephalin by these enzymes.
Gene_expression (coexpress) of mPC1 in pituitary associated with pox virus infection
15) Confidence 0.00 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8262946 Disease Relevance 0.10 Pain Relevance 0.11

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