INT5822

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Context Info
Confidence 0.76
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 51
Total Number 55
Disease Relevance 37.43
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
neutrophil 8
platelet 2
Basophil 2
joint 2
macrophages 1
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 116 100.00 Very High Very High Very High
Cluster headache 16 99.84 Very High Very High Very High
Inflammation 898 99.40 Very High Very High Very High
ischemia 10 99.00 Very High Very High Very High
Arthritis 178 98.24 Very High Very High Very High
chemokine 33 97.24 Very High Very High Very High
Inflammatory stimuli 20 97.04 Very High Very High Very High
fibrosis 147 96.60 Very High Very High Very High
aspirin 89 94.32 High High
peptic ulcer disease 4 94.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1081 100.00 Very High Very High Very High
Pancreatic Cancer 252 99.86 Very High Very High Very High
Cluster Headache 16 99.84 Very High Very High Very High
Pulmonary Disease 1414 99.54 Very High Very High Very High
Hypersensitivity 52 99.40 Very High Very High Very High
Ulcers 16 99.36 Very High Very High Very High
Disease 311 99.12 Very High Very High Very High
Cv Unclassified Under Development 9 99.00 Very High Very High Very High
Occupational Lung Diseases 604 98.48 Very High Very High Very High
Asthma 412 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lower limit of quantification for LTB4, expressed as the lowest point of the calibration curve, was 100 pg/mL.
Gene_expression (expressed) of LTB4
1) Confidence 0.76 Published 2004 Journal Rapid Commun. Mass Spectrom. Section Abstract Doc Link 15499663 Disease Relevance 0.55 Pain Relevance 0.22
Expression of BLT receptors can be up-regulated during inflammation; however, the specific inflammatory stimuli responsible for their induction have not yet been fully characterized.
Gene_expression (Expression) of BLT associated with inflammation and inflammatory stimuli
2) Confidence 0.75 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.73 Pain Relevance 0.27
In other hand, we did not found any changes in BLT receptors expression between controls and disease groups.
Gene_expression (expression) of BLT associated with disease
3) Confidence 0.75 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.25 Pain Relevance 0.09
The production of LTB4 induced by zymosan in the joint was reduced by the pretreatment with fucoidan or antineutrophil antibody as well as the production of PGE2 induced by LTB4.
Gene_expression (production) of LTB4 in joint
4) Confidence 0.67 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.32 Pain Relevance 0.19
Concluding, targeting LTB4 synthesis/action might constitute useful therapeutic approaches to inhibit articular inflammatory hypernociception.
Gene_expression (synthesis/action) of LTB4 in articular associated with inflammation
5) Confidence 0.66 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.22 Pain Relevance 0.07
However are in contrast with other reports showing increased levels of LTB4 and BLT receptors in allergic versus non-allergic nasal polyp patients [10].
Gene_expression (levels) of BLT in nasal associated with hypersensitivity and nasal polyps
6) Confidence 0.58 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.35 Pain Relevance 0.12
Furthermore, zymosan induced an increase in joint LTB4 production.
Gene_expression (production) of LTB4 in joint
7) Confidence 0.52 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 17913976 Disease Relevance 0.38 Pain Relevance 0.23
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Gene_expression (expression) of leukotriene B4 receptor in neutrophils associated with chemokine and arthritis
8) Confidence 0.46 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.63 Pain Relevance 0.35
Mice depleted of neutrophils using anti-Gr-1 (RB6) antibodies are resistant [126] and neutrophil expression of leukotriene B4 receptor BLT1 was reported to be absolutely required for arthritis generation and chemokine production in this model [127].
Gene_expression (expression) of BLT1 in neutrophils associated with chemokine and arthritis
9) Confidence 0.46 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794524 Disease Relevance 0.63 Pain Relevance 0.35
In vitro studies demonstrated that zymosan stimulates LTC4 synthesis by peritoneal cells whereas LTE4, LTD4, LTB4 or monoHETES were not detectable (using HPLC methods).
Neg (not) Gene_expression (detectable) of LTB4
10) Confidence 0.46 Published 1985 Journal Prostaglandins Section Abstract Doc Link 3001831 Disease Relevance 0.21 Pain Relevance 0.18
LTB4 values in EBC were expressed as total amount (in picograms) of leukotriene expired in the 15-minute breath test (LT concentrations × volume of EBC).
Gene_expression (expressed) of LTB4
11) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0 Pain Relevance 0
Using immunoassays, LTB4 has been detected in EBC in healthy subjects and found increased in asthmatic adults [11,12] and children [13,14].
Gene_expression (detected) of LTB4 associated with occupational lung diseases
12) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.92 Pain Relevance 0.17
A significant reduction in exhaled LTB4 levels was observed only in the group of children who were receiving 200 ?
Gene_expression (levels) of LTB4
13) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 1.13 Pain Relevance 0.10
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Gene_expression (production) of LTB4 in neutrophil
14) Confidence 0.30 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.32 Pain Relevance 0.03
Altogether, the results suggest that SGE has anti-inflammatory properties that are associated with inhibition of TNF-alpha and LTB4 production and/or with the neutrophil chemotactic activity of LTB4.
Gene_expression (production) of LTB4 in neutrophil associated with inflammation
15) Confidence 0.30 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.49 Pain Relevance 0.21
The OVA-induced production of TNF-alpha, IL-1beta and leukotriene B4 (LTB4), neutrophil chemotactic mediators in this model, were inhibited by SGE.
Gene_expression (production) of leukotriene B4 in neutrophil
16) Confidence 0.30 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.32 Pain Relevance 0.03
To increase specificity, LTB4 was detected in MS/MS mode.
Gene_expression (detected) of LTB4
17) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.20 Pain Relevance 0
Seven asthmatic children who were treated with the higher dose of fluticasone had undetectable levels of exhaled LTB4 (Figure 3).
Gene_expression (levels) of LTB4 associated with occupational lung diseases
18) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.54 Pain Relevance 0.03
The peak area ratios for LTB4/LTB4-d4 were plotted versus LTB4 concentrations.
Gene_expression (concentrations) of LTB4
19) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0 Pain Relevance 0
To adjust for possible variations in the EBC sample volume, LTB4 values in EBC were expressed as total amount of the eicosanoid expired over a standard period of collection.
Gene_expression (values) of LTB4
20) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1283153 Disease Relevance 0.35 Pain Relevance 0.09

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