INT58226

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 18.09
Pain Relevance 12.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
macrophage 6
temporomandibular joints 4
frontal cortex 4
neutrophil 4
blood 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 58 100.00 Very High Very High Very High
Nerve growth factor 15 100.00 Very High Very High Very High
Inflammatory response 3 99.92 Very High Very High Very High
Neuropathic pain 10 99.90 Very High Very High Very High
Paracetamol 14 99.82 Very High Very High Very High
Morphine 22 99.70 Very High Very High Very High
Hyperalgesia 11 99.64 Very High Very High Very High
isoflurane 10 99.36 Very High Very High Very High
Calcitonin gene-related peptide 6 99.04 Very High Very High Very High
Nicotine 1 98.42 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 11 100.00 Very High Very High Very High
Adhesions 9 100.00 Very High Very High Very High
Hypersensitivity 4 100.00 Very High Very High Very High
Leishmaniasis 14 99.92 Very High Very High Very High
Neuropathic Pain 17 99.90 Very High Very High Very High
Wallerian Degeneration 15 99.88 Very High Very High Very High
Nervous System Injury 23 99.82 Very High Very High Very High
INFLAMMATION 44 99.74 Very High Very High Very High
Hyperalgesia 14 99.64 Very High Very High Very High
Stress 36 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renal cortices of isoflurane-treated mice had significantly reduced expression of intercellular adhesion molecule 1, TNF-alpha, and IL-1beta messenger RNA and showed less apoptosis.
Negative_regulation (reduced) of Gene_expression (expression) of IL-1beta associated with isoflurane, apoptosis and adhesions
1) Confidence 0.57 Published 2007 Journal Shock Section Abstract Doc Link 17414419 Disease Relevance 1.35 Pain Relevance 0.94
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Negative_regulation (deficient) of Gene_expression (production) of IL-1beta associated with wallerian degeneration and cytokine
2) Confidence 0.57 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.41 Pain Relevance 0.27
Citalopram at 10(-6) mol/l tended to inhibit the production of IL-1beta by the XS52 cell line.
Negative_regulation (inhibit) of Gene_expression (production) of IL-1beta
3) Confidence 0.57 Published 2007 Journal Acta Derm. Venereol. Section Abstract Doc Link 17721644 Disease Relevance 0.20 Pain Relevance 0.26
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (delayed) of Gene_expression (expression) of IL-1beta associated with paracetamol
4) Confidence 0.57 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.
Negative_regulation (downregulation) of Gene_expression (expression) of IL-1beta
5) Confidence 0.42 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.82 Pain Relevance 0.20
In rats pretreated with EcN, a significant downregulation of mRNA and protein expression for IL-1beta, COX-2 and PPARgamma and increased expression of HSP70 without major change in activation of NFkappaB were observed.
Negative_regulation (downregulation) of Gene_expression (expression) of IL-1beta
6) Confidence 0.42 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.81 Pain Relevance 0.20
Among them, compound 4a, (S)-2-(4-fluorophenyl)-4-(1,2,3,5,6,8a-hexahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole (R-132811), achieved the most promising results in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034, 0.572, >10, and >10 microM, respectively; (ii) inhibition of TNFalpha, IL-1beta, IL-6, and IL-8 production in human whole blood: IC(50)=0.026, 0.020, 0.88, and 0.016 microM, respectively; (iii) inhibition of LPS induced TNFalpha, IL-1beta and IL-6 production in mice: ID(50)=0.93, 8.63, and 0.11 mg/kg, p.o., respectively; (iv) inhibition of anti-collagen antibody-induced arthritis in mice: ID(50)=2.22 mg/kg, p.o.; (v) inhibition of collagen-induced arthritis in mice: ID(50)=2.38 mg/kg, p.o.; (vi) prophylactic effect on adjuvant-induced arthritis in rats: ID(50)=3.1 mg/kg, p.o.; (vii) therapeutic effect on adjuvant-induced arthritis in rats: ID(50)=4.9 mg/kg, p.o.; (viii) analgesic effect on adjuvant-induced arthritic pain in rats: ID(50)=2.9 mg/kg, p.o.).
Negative_regulation (inhibition) of Gene_expression (production) of IL-1beta in blood associated with pain, analgesic, rheumatoid arthritis and arthritis
7) Confidence 0.42 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20637613 Disease Relevance 0.59 Pain Relevance 0.48
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (reduced) of Gene_expression (expression) of IL-1beta associated with paracetamol
8) Confidence 0.42 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
Mice with CL showed sustained increase in the levels of IL-1beta and NGF which were reversed by thymulin (1 microg).
Negative_regulation (reversed) of Gene_expression (levels) of IL-1beta associated with leishmaniasis and nerve growth factor
9) Confidence 0.42 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 0.92 Pain Relevance 0.80
The exposure to WRS was accompanied by an increase in gastric mucosal expression of IL-1beta, ghrelin, PPARgamma, HSP70 and COX-2.
Negative_regulation (mucosal) of Gene_expression (expression) of IL-1beta associated with stress
10) Confidence 0.41 Published 2009 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20224150 Disease Relevance 0.89 Pain Relevance 0.21
Subdiaphragmatic vagotomy abolishes several effects of peripherally injected IL-1beta and LPS (e.g., decreased food-motivated behavior and social exploration, central expression of cytokines).
Negative_regulation (abolishes) of Gene_expression (expression) of IL-1beta associated with cytokine
11) Confidence 0.41 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9128919 Disease Relevance 0.36 Pain Relevance 0.69
Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1beta and NGF expression induced by CFA.
Negative_regulation (diminishes) of Gene_expression (expression) of IL-1beta associated with nerve growth factor and hypersensitivity
12) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651226 Disease Relevance 0.68 Pain Relevance 0.60
Perineural injection of nicotine (20nmol), a macrophage suppressor, prevented PSL-induced neuropathic pain and suppressed MIP-1alpha and IL-1beta expressions.
Negative_regulation (suppressed) of Gene_expression (expressions) of IL-1beta in macrophage associated with nicotine and neuropathic pain
13) Confidence 0.41 Published 2010 Journal Pain Section Abstract Doc Link 20223588 Disease Relevance 0.81 Pain Relevance 1.01
Moreover, SNI animals displayed increased interleukin-1beta (IL-1beta) gene expression within the frontal cortex and concurrent increases in the expression of glial fibrillary acidic protein (GFAP) within the periaqueductal grey (PAG).
Negative_regulation (displayed) of Gene_expression (expression) of interleukin-1beta in frontal cortex associated with nervous system injury, periaqueductal grey and urological neuroanatomy
14) Confidence 0.41 Published 2010 Journal Mol. Psychiatry Section Abstract Doc Link 19773812 Disease Relevance 2.32 Pain Relevance 0.58
Our objective was to characterize the molecular mechanisms responsible for the hepatic inflammatory response to time-limited TNF-alpha and IL-1beta expression.
Negative_regulation (time-limited) of Gene_expression (expression) of IL-1beta associated with inflammatory response
15) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.29 Pain Relevance 0.22
RESULTS: A single injection of FIV(HuMOR) into the temporomandibular joints of Col1-IL-1beta(XAT)-transgenic mice 1 week prior to induction of arthritis prevented the development of orofacial pain and joint dysfunction, and reduced the degree of histopathologic abnormality in the joint.
Negative_regulation (prevented) of Gene_expression (injection) of IL-1beta in temporomandibular joints
16) Confidence 0.41 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17530644 Disease Relevance 0.08 Pain Relevance 0
RESULTS: A single injection of FIV(HuMOR) into the temporomandibular joints of Col1-IL-1beta(XAT)-transgenic mice 1 week prior to induction of arthritis prevented the development of orofacial pain and joint dysfunction, and reduced the degree of histopathologic abnormality in the joint.
Negative_regulation (reduced) of Gene_expression (injection) of IL-1beta in temporomandibular joints
17) Confidence 0.41 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17530644 Disease Relevance 0.08 Pain Relevance 0
We conclude that thymulin can modulate the hyperalgesia induced by CL by decreasing the levels of the proinflammatory factors IL-1beta and NGF.
Negative_regulation (decreasing) of Gene_expression (levels) of IL-1beta associated with leishmaniasis, hyperalgesia and nerve growth factor
18) Confidence 0.41 Published 2002 Journal Brain Behav. Immun. Section Abstract Doc Link 12096890 Disease Relevance 1.04 Pain Relevance 0.77
CGRP(8-37) or combination of SR 140333 and SR 48968 diminished neutrophil accumulation, MPO levels and IL-1beta production, airway hyperresponsiveness was inhibited only by SR 48968.
Negative_regulation (diminished) of Gene_expression (production) of IL-1beta in neutrophil associated with urological neuroanatomy and calcitonin gene-related peptide
19) Confidence 0.41 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17291600 Disease Relevance 0.61 Pain Relevance 1.05
Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.
Neg (failed) Negative_regulation (diminish) of Gene_expression (production) of IL-1beta in macrophage associated with cytokine and morphine
20) Confidence 0.41 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.18 Pain Relevance 1.02

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