INT58229

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Context Info
Confidence 0.01
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
molecular_function (Fam166a) cellular_component (Fam166a) biological_process (Fam166a)
Anatomy Link Frequency
thymocyte 6
Il1b (Mus musculus)
Fam166a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
antagonist 10 99.44 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta modulates the concanavalin-A-induced expression of proenkephalin A mRNA in murine thymocytes.
IL-1 beta Regulation (modulates) of Gene_expression (expression) of mRNA in thymocytes associated with enkephalin
1) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.20
We now show that this Con-A-induced expression of PEA mRNA is modulated by the cytokine murine interleukin-1 beta (mIL-1 beta) in a biphasic, dose-dependent manner.
mIL-1 beta Regulation (modulated) of Gene_expression (expression) of mRNA associated with cytokine
2) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.05
The present study demonstrates that PEA mRNA expression is regulated by IL-1 beta, which is thought to play a role in thymocyte maturation.
IL-1 beta Regulation (regulated) of Gene_expression (expression) of mRNA in thymocyte
3) Confidence 0.01 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.11
Both the enhancing and inhibiting effects of mIL-1 beta in the Con-A-induced expression of PEA mRNA were reversed by a 100-fold excess of interleukin-1 receptor antagonist protein, but not by a 10-fold excess of interleukin-1 receptor antagonist protein.
mIL-1 beta Regulation (effects) of Gene_expression (expression) of mRNA associated with antagonist
4) Confidence 0.00 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.13
The effects of mIL-1 beta on PEA mRNA expression in Con-A-activated thymocytes are different from its effects on Con-A-stimulated thymocyte proliferation.
mIL-1 beta Regulation (effects) of Gene_expression (expression) of mRNA in thymocyte
5) Confidence 0.00 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.13

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