INT58288

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 83
Total Number 89
Disease Relevance 82.23
Pain Relevance 23.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp)
Anatomy Link Frequency
plasma 12
liver 10
monocyte 8
mononuclear cell 8
erythrocyte 4
Crp (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 135 100.00 Very High Very High Very High
Pain 96 100.00 Very High Very High Very High
Inflammatory marker 75 100.00 Very High Very High Very High
Adalimumab 172 99.84 Very High Very High Very High
Infliximab 126 99.84 Very High Very High Very High
Paracetamol 9 99.84 Very High Very High Very High
Perioperative pain 1 99.84 Very High Very High Very High
backache 11 99.78 Very High Very High Very High
cytokine 281 99.52 Very High Very High Very High
Fibrositis 27 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 826 100.00 Very High Very High Very High
Cv General 3 Under Development 119 100.00 Very High Very High Very High
Pain 89 100.00 Very High Very High Very High
Sepsis 225 99.92 Very High Very High Very High
Disease 496 99.90 Very High Very High Very High
Leukocytosis 3 99.88 Very High Very High Very High
Coronary Heart Disease 143 99.84 Very High Very High Very High
Renal Disease 27 99.84 Very High Very High Very High
Post Operative Pain 1 99.84 Very High Very High Very High
Low Back Pain 128 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings can be explained by an enhanced production of cytokines, which in turn trigger CRP synthesis, induced by postoperative pain due to the LAST procedure.
Positive_regulation (induced) of Gene_expression (synthesis) of CRP associated with perioperative pain, thoracotomy and cytokine
1) Confidence 0.61 Published 2002 Journal Jpn Heart J Section Abstract Doc Link 12227696 Disease Relevance 0.17 Pain Relevance 0.32
CONCLUSIONS: CRP and TF expression is markedly increased in plaques derived from patients with ACS as compared to SA patients.
Positive_regulation (increased) of Gene_expression (expression) of CRP in plaques
2) Confidence 0.52 Published 2009 Journal Atherosclerosis Section Body Doc Link 18508060 Disease Relevance 0.14 Pain Relevance 0
Procalcitonin values were significantly higher in CS patients with respect to the other two subgroups (P < 0.001, P < 0.001) while CRP levels were higher than NSTEMI/UA patients (P < 0.001) but not with respect to STEMI patients (P = 0.063).
Positive_regulation (higher) of Gene_expression (levels) of CRP associated with cv general 2 under development
3) Confidence 0.49 Published 2009 Journal Intern Emerg Med Section Abstract Doc Link 19585221 Disease Relevance 1.88 Pain Relevance 0.29
CRP is a reliable early indicator of inflammation or injury.[1213] Mustard et al. documented that serial postoperative CRP levels could predict septic complications before their clinical manifestation.[14]
Positive_regulation (postoperative) of Gene_expression (levels) of CRP associated with inflammation and injury
4) Confidence 0.49 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2702981 Disease Relevance 1.31 Pain Relevance 0.26
[Prognostic value of C-reactive protein and troponin T level in patients with unstable angina pectoris].
Positive_regulation (value) of Gene_expression (level) of C-reactive protein associated with angina
5) Confidence 0.49 Published 2006 Journal J Cardiol Section Title Doc Link 16637251 Disease Relevance 0.57 Pain Relevance 0.61
Each increasing quartile of NT-proBNP or CRP level was associated with a greater risk of PMCE after adjustment for traditional clinical risk factors.
Positive_regulation (increasing) of Gene_expression (level) of CRP
6) Confidence 0.47 Published 2010 Journal Heart Section Abstract Doc Link PMC2791233 Disease Relevance 0.60 Pain Relevance 0
However, after adjustment for confounding factors, elevated CRP levels appear not to lead to elevated BP (Smith et al 2005).
Positive_regulation (elevated) of Gene_expression (levels) of CRP
7) Confidence 0.46 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.40 Pain Relevance 0.07
However, after adjustment for confounding factors, elevated CRP levels appear not to lead to elevated BP (Smith et al 2005).
Neg (not) Positive_regulation (lead) of Gene_expression (levels) of CRP
8) Confidence 0.46 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.41 Pain Relevance 0.07
In contrast, the improvement of PGA, PhGA, VAS, ESR and CRP was not significantly different between groups.
Positive_regulation (improvement) of Gene_expression (improvement) of CRP associated with pain
9) Confidence 0.46 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18030515 Disease Relevance 0.93 Pain Relevance 1.12
In particular, obesity is strongly associated with CRP concentration (6, 10), because adipose tissue produces proinflammatory cytokines such as interleukin-6 (IL-6), which stimulates the production of CRP (11).
Positive_regulation (stimulates) of Gene_expression (production) of CRP in adipose tissue associated with obesity and cytokine
10) Confidence 0.46 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721988 Disease Relevance 1.08 Pain Relevance 0.11
Increased serum CRP levels did not add further significant prognostic information in this specific group of patients with unstable angina, although this issue needs to be addressed in larger studies.


Positive_regulation (Increased) of Gene_expression (levels) of CRP
11) Confidence 0.46 Published 2002 Journal Ital Heart J Section Body Doc Link 12506522 Disease Relevance 0 Pain Relevance 0
Mean CRP measurement
Positive_regulation (Mean) of Gene_expression (measurement) of CRP
12) Confidence 0.45 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2585569 Disease Relevance 0.54 Pain Relevance 0.07
This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients



Positive_regulation (increased) of Gene_expression (levels) of CRP associated with inflammation
13) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3016330 Disease Relevance 2.51 Pain Relevance 0.14
This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients



Positive_regulation (levels) of Gene_expression (levels) of CRP associated with inflammation
14) Confidence 0.45 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3016330 Disease Relevance 2.45 Pain Relevance 0.14
The levels of CRP and other inflammatory markers are significantly elevated in patients with unstable angina.
Positive_regulation (elevated) of Gene_expression (levels) of CRP associated with angina and inflammatory marker
15) Confidence 0.44 Published 2004 Journal Kardiol Pol Section Abstract Doc Link 15531933 Disease Relevance 0.28 Pain Relevance 0.26
At the molecular level, production of CRP is induced by proinflammatory cytokines IL-1, IL-6, and IL-17 in the liver, although extra hepatic production most likely contributes to systemic concentrations.
Spec (likely) Positive_regulation (induced) of Gene_expression (production) of CRP in liver associated with cytokine
16) Confidence 0.42 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19803417 Disease Relevance 0.60 Pain Relevance 0.50
Cytokines exert their biological effects on CRP by signaling through their receptors on hepatic cells and activating different kinases and phosphatases leading to translocation of various transcription factors on CRP gene promoter and production of CRP protein.
Positive_regulation (activating) of Gene_expression (production) of CRP associated with cytokine
17) Confidence 0.42 Published 2009 Journal Adv Clin Chem Section Abstract Doc Link 19803417 Disease Relevance 0.62 Pain Relevance 0.62
mTSS values observed among adalimumab-treated patients, five occurred in this CRP group (with the other three being in patients with baseline CRP ?
Positive_regulation (occurred) of Gene_expression (group) of CRP associated with adalimumab
18) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.06 Pain Relevance 0.36
mTSS was inhibited regardless of the concentration of time-averaged CRP.
Positive_regulation (averaged) of Gene_expression (averaged) of CRP
19) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.57 Pain Relevance 0.39
mTSS being greatest for the placebo-treated groups with greatest time-averaged CRP, and ?
Positive_regulation (averaged) of Gene_expression (averaged) of CRP
20) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911906 Disease Relevance 0.08 Pain Relevance 0.44

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