INT58290

Context Info Confidence 0.37 First Reported 1993 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 3.56 Pain Relevance 1.24

Anatomy Mention Frequency plasma cell 1 appa (Danio rerio)

Pain Term Frequency Confidence Heat cINOD 8 99.80 Kinase C 1 94.60 addiction 2 84.44 opiate 2 84.00 withdrawal 1 82.36 Inflammation 1 75.32 peripheral neuropathy 1 72.08 Pain 3 71.40 carpal tunnel syndrome 1 68.24 Preemptive analgesia 1 50.00

Disease Term Frequency Confidence Heat Pancreatitis 9 100.00 Alzheimer's Dementia 5 100.00 Neuroblastoma 1 98.44 Amyloidosis 4 98.04 Shock 1 96.48 Proteinuria 2 89.36 Disorder Of Lipid Metabolism 2 88.16 Opiate Addiction 2 84.44 Disease 4 83.12 Poisoning 1 83.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The authors suggest a scheme of APP prevention with the use of aldehydes, antioxidants, inhibitors of proteolytic enzymes, a complex of vitamins.

Negative_regulation (prevention) of APP associated with pancreatitis

1) Confidence 0.37 Published 1993 Journal Khirurgiia (Mosk) Section Abstract Doc Link 8271735 Disease Relevance 1.09 Pain Relevance 0.14

CONCLUSION: Intraperitoneal bupivacaine administration both immediately after placement of trocars and at the end of surgery was found to be effective in reducing the intensity of AVP but not in reducing STP, APP, or postoperative analgesia consumption after nonadvanced gynecologic laparoscopic procedures.

Neg (not) Negative_regulation (reducing) of APP

2) Confidence 0.30 Published 2005 Journal Journal of minimally invasive gynecology Section Body Doc Link 16036193 Disease Relevance 0 Pain Relevance 0

It is important to recognise that amyloidosis is a dynamic process and chemotherapy-induced reduction of the activity of the plasma cell clone reduces the supply of the amyloid precursor protein and can result in a major regression of the deposits.

Negative_regulation (reduces) of amyloid precursor protein in plasma cell associated with amyloidosis and alzheimer's dementia

3) Confidence 0.21 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060811 Disease Relevance 1.64 Pain Relevance 0.10

These NSAIDs markedly reduced the levels of the cellular APP holoprotein, further accelerating non-amyloidogenic processes. sAPP alpha release, induced by nimesulide and Thal, was modulated by inhibitors of protein kinase C and Erk mitogen-activated protein (MAP) kinase.

Negative_regulation (reduced) of APP holoprotein associated with kinase c and cinod

4) Confidence 0.04 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12070143 Disease Relevance 0.67 Pain Relevance 0.72

These indexes were suggested as a possible surrogate biological marker of DAD, and immune-stimulators were recommended during DAD treatment to restore the decreased level of protective APP of these patients.

Negative_regulation (decreased) of APP

5) Confidence 0.02 Published 2001 Journal Int J Circumpolar Health Section Abstract Doc Link 11507984 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

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