INT58300

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.65
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLEKHM1)
Anatomy Link Frequency
platelet 4
plasma 2
PLEKHM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 99.78 Very High Very High Very High
Inflammation 1 82.16 Quite High
local anesthetic 1 80.52 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 2 86.28 High High
INFLAMMATION 5 85.52 High High
Injury 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PACBA in the same doses did not affect the production of TxB2.
Neg (not) Regulation (affect) of Gene_expression (production) of TxB2
1) Confidence 0.05 Published 1997 Journal Thromb. Res. Section Abstract Doc Link 9175234 Disease Relevance 0.08 Pain Relevance 0.20
On the other hand, flunixin was clearly a more potent inhibitor of TxB2 production and adrenaline-induced platelet aggregation than tolfenamic acid, the IC50 values in TxB2 production being 0.28 +/- 0.02 microM and 2.6 +/- 0.3 microM for flunixin and tolfenamic acid, respectively.
Regulation (values) of Gene_expression (production) of TxB2 in platelet
2) Confidence 0.03 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.25 Pain Relevance 0.08
On the other hand, flunixin was clearly a more potent inhibitor of TxB2 production and adrenaline-induced platelet aggregation than tolfenamic acid, the IC50 values in TxB2 production being 0.28 +/- 0.02 microM and 2.6 +/- 0.3 microM for flunixin and tolfenamic acid, respectively.
Regulation (values) of Gene_expression (production) of TxB2 in platelet
3) Confidence 0.03 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.24 Pain Relevance 0.07
The relationship between endoscopically observed gastric mucosal damage, elicited following repeated oral intake for 7 d of four NSAIDs, to their effects on antral and fundic production of PGE2, 6-keto-PGF1 alpha and TxB2 (assayed by GC-MS), mucosal histology and plasma concentration profiles was studied in 40 normal males.
Regulation (effects) of Gene_expression (production) of TxB2 in plasma associated with cinod
4) Confidence 0.01 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273571 Disease Relevance 0.07 Pain Relevance 0.25

General Comments

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