INT58301

Context Info Confidence 0.70 First Reported 1993 Last Reported 2011 Negated 0 Speculated 1 Reported most in Abstract Documents 87 Total Number 91 Disease Relevance 80.19 Pain Relevance 23.99

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo) lysosome (Mpo)

Anatomy Link Frequency lung 9 neutrophils 6 paw 4 brain 3 macrophages 2 Mpo (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 1220 100.00 ischemia 123 100.00 withdrawal 29 99.76 Spinal cord 90 99.68 Paracetamol 59 99.36 methotrexate 27 99.36 substance P 39 98.74 qutenza 17 98.70 Leflunomide 24 98.64 Inflammatory response 200 98.60

Disease Link Frequency Relevance Heat INFLAMMATION 1375 100.00 Urological Neuroanatomy 607 100.00 Cv Unclassified Under Development 116 100.00 Injury 1374 99.98 Infection 119 99.96 Burns 787 99.84 Disease 249 99.84 Pressure And Volume Under Development 101 99.72 Acute Chest Syndrome 105 99.62 Adult Respiratory Distress Syndrome 35 99.58

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Anatomy

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CFA injection increased 4-fold MPO activity and 27-fold the number of neutrophils in the mouse paw after 24 h.

Positive_regulation (increased) of MPO in paw associated with urological neuroanatomy

1) Confidence 0.70 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 17070780 Disease Relevance 1.44 Pain Relevance 0.90

Twelve weeks after infection, chronic granulomatous inflammation led to proliferation of the muscle layer and to a further increase in MPO activity, whereas IL-1beta production normalized.

Positive_regulation (increase) of MPO in muscle associated with granulomatous inflammation, inflammation, urological neuroanatomy and infection

2) Confidence 0.70 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292613 Disease Relevance 0.87 Pain Relevance 0.20

Biochemical analysis showed a significant increase in lipid peroxidation, nitrite and myeloperoxidase levels and a decrease in the reduced glutathione (GSH) levels in brain homogenates.

Positive_regulation (increase) of myeloperoxidase in brain

3) Confidence 0.70 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18336891 Disease Relevance 0.50 Pain Relevance 0.33

Gastric thiobarbituric acid reactive substances (TBARS) levels and myeloperoxidase (MPO) activity substantially increased 3 hr after indomethacin administration.

Positive_regulation (increased) of MPO associated with urological neuroanatomy

4) Confidence 0.69 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184426 Disease Relevance 0.83 Pain Relevance 0.23

The current study further substantiates that inhibition of NEP exacerbates SB injury as there was a significant increase in MPO activity in CGS 24592 pretreated animals with SB injury compared to those with SB injury alone (Figure 3).

Positive_regulation (increase) of MPO associated with burns, injury and urological neuroanatomy

5) Confidence 0.69 Published 2009 Journal Toxicology Mechanisms and Methods Section Body Doc Link PMC2736052 Disease Relevance 1.98 Pain Relevance 0.22

Systemic inflammation and the intensity of MPO activation in the brain were significantly reduced throughout the 1 month post-injury period as compared to mice either with whole-body exposure to blast or those with head protection.

Positive_regulation (activation) of MPO in brain associated with inflammation, injury and urological neuroanatomy

6) Confidence 0.68 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.09 Pain Relevance 0.25

Importantly, the increase in MPO activity observed in mice with head protection was equal to corresponding changes found in the brain of animals exposed to whole-body blast without head protection, suggesting that head protection did not prevent inflammation in the brain and implying the importance of inflammatory cells of systemic origin in the pathobiology of blast-induced inflammatory processes in the brain.

Positive_regulation (increase) of MPO in head associated with inflammation and urological neuroanatomy

7) Confidence 0.68 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009449 Disease Relevance 1.22 Pain Relevance 0.22

Thus, intracolonic infusion to mice of the PAR-2-activating peptide, SLIGRL, increased both myeloperoxidase (MPO) activity and damage scores indicating colonic inflammation, and enhanced colonic permeability to (51)Cr-EDTA from 2 to 4 h after its infusion.

Positive_regulation (increased) of MPO associated with inflammation and urological neuroanatomy

8) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12682265 Disease Relevance 0.74 Pain Relevance 0.49

Thus, intracolonic infusion to mice of the PAR-2-activating peptide, SLIGRL, increased both myeloperoxidase (MPO) activity and damage scores indicating colonic inflammation, and enhanced colonic permeability to (51)Cr-EDTA from 2 to 4 h after its infusion.

Positive_regulation (increased) of myeloperoxidase associated with inflammation and urological neuroanatomy

9) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12682265 Disease Relevance 0.74 Pain Relevance 0.49

GSH levels were reduced while MDA, MPO and oxidized protein levels were increased significantly following AA administration.

Positive_regulation (increased) of MPO associated with paracetamol and urological neuroanatomy

10) Confidence 0.67 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.63 Pain Relevance 0.63

In Figure 3 data are displayed demonstrating that even at 30 minutes after incision, MPO activity was measurably increased from baseline, and that 10 mg/kg but not 0.1 mg/kg morphine injection prior to incision strongly reduced the MPO activity at both time points.

Positive_regulation (increased) of MPO associated with urological neuroanatomy and morphine

11) Confidence 0.66 Published 2007 Journal Mol Pain Section Body Doc Link PMC2096620 Disease Relevance 0.76 Pain Relevance 0.89

Acetaminophen treatment caused a significant (P < 0.05-0.001) decrease in GSH levels whereas MDA levels and MPO activity were increased in both tissues.

Positive_regulation (increased) of MPO associated with paracetamol and urological neuroanatomy

12) Confidence 0.66 Published 2005 Journal J Appl Toxicol Section Abstract Doc Link 15669031 Disease Relevance 0.23 Pain Relevance 0.70

In addition, trypsin produced an increase in myeloperoxidase (MPO) activity, which was significantly reduced in PAR-2-deficient mice.

Positive_regulation (increase) of MPO associated with urological neuroanatomy

13) Confidence 0.66 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.95 Pain Relevance 0.20

In addition, trypsin produced an increase in myeloperoxidase (MPO) activity, which was significantly reduced in PAR-2-deficient mice.

Positive_regulation (increase) of myeloperoxidase associated with urological neuroanatomy

14) Confidence 0.66 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18083162 Disease Relevance 0.95 Pain Relevance 0.20

Acetaminophen caused a significant decrease in the GSH level of the tissue, which was accompanied with significant increases in the hepatic luminol and lucigenin chemiluminescence values, malondialdehyde level, MPO activity and collagen content.

Positive_regulation (increases) of MPO associated with paracetamol and urological neuroanatomy

15) Confidence 0.64 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16822497 Disease Relevance 0.52 Pain Relevance 0.59

MPO activity, a marker of neutrophil aggregation at the site of inflammation, is frequently increased under ulcerated conditions and reduced with the healing process [30].

Positive_regulation (increased) of MPO in neutrophil associated with inflammation and urological neuroanatomy

16) Confidence 0.63 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.63 Pain Relevance 0.18

Consistent with this, we also observed ulceration-induced MPO activity up to the third day, followed by its gradual reduction on the seventh day (Table 3).

Positive_regulation (induced) of MPO associated with urological neuroanatomy

17) Confidence 0.63 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2976071 Disease Relevance 0.64 Pain Relevance 0.11

The mean MPO levels markedly increased in burn mice (32.8±3.3 vs 11.9 ±1.2 unit/g tissue, P <0.01) compared with sham group.

Positive_regulation (increased) of MPO associated with burns and urological neuroanatomy

18) Confidence 0.63 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.84 Pain Relevance 0

In the present study, we found that MPO activity in renal tissue was markedly elevated after thermal injury and this increase was significantly attenuated after in vivo administration of CORM-2.

Positive_regulation (elevated) of MPO associated with injury and urological neuroanatomy

19) Confidence 0.63 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2430988 Disease Relevance 1.08 Pain Relevance 0.10

Thermal injury induced a marked 11-fold increase of MPO activity in lung compared with control group (87 ± 8.17 vs. 6.73 ± 0.8 Units/g tissue) (Figure 2B).

Positive_regulation (increase) of MPO in lung associated with injury and urological neuroanatomy

20) Confidence 0.63 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2901327 Disease Relevance 1.32 Pain Relevance 0

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