INT58301
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
CFA injection increased 4-fold MPO activity and 27-fold the number of neutrophils in the mouse paw after 24 h. | |||||||||||||||
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Twelve weeks after infection, chronic granulomatous inflammation led to proliferation of the muscle layer and to a further increase in MPO activity, whereas IL-1beta production normalized. | |||||||||||||||
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Biochemical analysis showed a significant increase in lipid peroxidation, nitrite and myeloperoxidase levels and a decrease in the reduced glutathione (GSH) levels in brain homogenates. | |||||||||||||||
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Gastric thiobarbituric acid reactive substances (TBARS) levels and myeloperoxidase (MPO) activity substantially increased 3 hr after indomethacin administration. | |||||||||||||||
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The current study further substantiates that inhibition of NEP exacerbates SB injury as there was a significant increase in MPO activity in CGS 24592 pretreated animals with SB injury compared to those with SB injury alone (Figure 3). | |||||||||||||||
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Systemic inflammation and the intensity of MPO activation in the brain were significantly reduced throughout the 1 month post-injury period as compared to mice either with whole-body exposure to blast or those with head protection. | |||||||||||||||
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Importantly, the increase in MPO activity observed in mice with head protection was equal to corresponding changes found in the brain of animals exposed to whole-body blast without head protection, suggesting that head protection did not prevent inflammation in the brain and implying the importance of inflammatory cells of systemic origin in the pathobiology of blast-induced inflammatory processes in the brain. | |||||||||||||||
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Thus, intracolonic infusion to mice of the PAR-2-activating peptide, SLIGRL, increased both myeloperoxidase (MPO) activity and damage scores indicating colonic inflammation, and enhanced colonic permeability to (51)Cr-EDTA from 2 to 4 h after its infusion. | |||||||||||||||
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Thus, intracolonic infusion to mice of the PAR-2-activating peptide, SLIGRL, increased both myeloperoxidase (MPO) activity and damage scores indicating colonic inflammation, and enhanced colonic permeability to (51)Cr-EDTA from 2 to 4 h after its infusion. | |||||||||||||||
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GSH levels were reduced while MDA, MPO and oxidized protein levels were increased significantly following AA administration. | |||||||||||||||
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In Figure 3 data are displayed demonstrating that even at 30 minutes after incision, MPO activity was measurably increased from baseline, and that 10 mg/kg but not 0.1 mg/kg morphine injection prior to incision strongly reduced the MPO activity at both time points.
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Acetaminophen treatment caused a significant (P < 0.05-0.001) decrease in GSH levels whereas MDA levels and MPO activity were increased in both tissues. | |||||||||||||||
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In addition, trypsin produced an increase in myeloperoxidase (MPO) activity, which was significantly reduced in PAR-2-deficient mice. | |||||||||||||||
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In addition, trypsin produced an increase in myeloperoxidase (MPO) activity, which was significantly reduced in PAR-2-deficient mice. | |||||||||||||||
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Acetaminophen caused a significant decrease in the GSH level of the tissue, which was accompanied with significant increases in the hepatic luminol and lucigenin chemiluminescence values, malondialdehyde level, MPO activity and collagen content. | |||||||||||||||
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MPO activity, a marker of neutrophil aggregation at the site of inflammation, is frequently increased under ulcerated conditions and reduced with the healing process [30]. | |||||||||||||||
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Consistent with this, we also observed ulceration-induced MPO activity up to the third day, followed by its gradual reduction on the seventh day (Table 3). | |||||||||||||||
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The mean MPO levels markedly increased in burn mice (32.8±3.3 vs 11.9 ±1.2 unit/g tissue, P <0.01) compared with sham group. | |||||||||||||||
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In the present study, we found that MPO activity in renal tissue was markedly elevated after thermal injury and this increase was significantly attenuated after in vivo administration of CORM-2. | |||||||||||||||
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Thermal injury induced a marked 11-fold increase of MPO activity in lung compared with control group (87 ± 8.17 vs. 6.73 ± 0.8 Units/g tissue) (Figure 2B). | |||||||||||||||
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