INT58302

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 11.14
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) oxidoreductase activity (Mpo)
lysosome (Mpo)
Anatomy Link Frequency
retina 2
skin 1
lung 1
ear 1
neutrophils 1
Mpo (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 117 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
cINOD 8 100.00 Very High Very High Very High
dexamethasone 4 100.00 Very High Very High Very High
b2 receptor 2 100.00 Very High Very High Very High
withdrawal 13 93.44 High High
Inflammatory marker 1 92.60 High High
COX-2 inhibitor 2 91.92 High High
Antinociceptive 1 91.28 High High
Inflammatory response 45 90.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 163 100.00 Very High Very High Very High
Urological Neuroanatomy 73 100.00 Very High Very High Very High
Pressure And Volume Under Development 10 100.00 Very High Very High Very High
Burns 74 99.68 Very High Very High Very High
Pleurisy 4 99.16 Very High Very High Very High
Injury 52 96.96 Very High Very High Very High
Shock 3 96.48 Very High Very High Very High
Endotoxemia 2 94.32 High High
Colitis 38 93.04 High High
Necrosis 8 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of anti-inflammatory compounds on edema formation and myeloperoxidase activity in the arachidonic acid-induced ear model in the mouse.
Regulation (Effect) of myeloperoxidase in ear associated with pressure and volume under development and inflammation
1) Confidence 0.62 Published 1993 Journal Agents Actions Section Title Doc Link 8273582 Disease Relevance 0.85 Pain Relevance 0.34
Intraperitoneal capsazepine (2.5 mg kg(-1), bid), significantly reduced the overall macroscopic damage severity compared with vehicle-treated animals (80% inhibition, P < 0.05); however, there was no effect on myeloperoxidase (MPO) levels.
Neg (no) Regulation (effect) of MPO associated with urological neuroanatomy
2) Confidence 0.60 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15601431 Disease Relevance 0.88 Pain Relevance 0.24
Intraperitoneal capsazepine (2.5 mg kg(-1), bid), significantly reduced the overall macroscopic damage severity compared with vehicle-treated animals (80% inhibition, P < 0.05); however, there was no effect on myeloperoxidase (MPO) levels.
Neg (no) Regulation (effect) of myeloperoxidase associated with urological neuroanatomy
3) Confidence 0.60 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15601431 Disease Relevance 0.88 Pain Relevance 0.24
The effects of several drugs (terfenadine, bradykinin B2 receptor antagonists: HOE 140, NPC 17731, diacerein, indomethacin, meloxicam, nabumetone, and dexamethasone) upon myeloperoxidase and nitrate levels were analyzed in an inflammation model characterized by biphasic peaks (4 and 48 h) of cell migration and of fluid leakage.
Spec (analyzed) Regulation (effects) of myeloperoxidase associated with inflammation, antagonist, b2 receptor and dexamethasone
4) Confidence 0.45 Published 1999 Journal Peptides Section Abstract Doc Link 10503773 Disease Relevance 0.31 Pain Relevance 0.27
Effects of anti-inflammatory drugs upon nitrate and myeloperoxidase levels in the mouse pleurisy induced by carrageenan.
Regulation (Effects) of myeloperoxidase associated with inflammation, pleurisy and cinod
5) Confidence 0.45 Published 1999 Journal Peptides Section Title Doc Link 10503773 Disease Relevance 0.36 Pain Relevance 0.32
Furthermore, an 8 days treatment with budlein A inhibited Complete Freund's adjuvant (10 microl/paw)-induced hypernociception, paw oedema and paw skin myeloperoxidase activity increase while not affecting the motor performance or myeloperoxidase activity in the stomach.
Neg (not) Regulation (affecting) of myeloperoxidase in skin associated with pressure and volume under development
6) Confidence 0.42 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17320857 Disease Relevance 0.67 Pain Relevance 0.50
As shown in Fig. 3C., MPO levels were unchanged in the burn group as compared to the sham animals at 3 hours after burn.
Neg (unchanged) Regulation (unchanged) of MPO associated with burns and urological neuroanatomy
7) Confidence 0.42 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.83 Pain Relevance 0.21
We studied the effects of high dosages of vitamin C, a water-soluble antioxidant, on the incidence of BT and on levels of lung myeloperoxidase in burned mice.
Regulation (effects) of myeloperoxidase in lung
8) Confidence 0.39 Published 1995 Journal J Burn Care Rehabil Section Abstract Doc Link 8582922 Disease Relevance 0.71 Pain Relevance 0
Previous studies have indicated that tissue MPO activity can be affected by other factors (19, 20). and that MPO values may not indicate the true presence of neutrophils.
Regulation (affected) of MPO in neutrophils associated with urological neuroanatomy
9) Confidence 0.23 Published 2004 Journal BMC Clin Pathol Section Body Doc Link PMC503395 Disease Relevance 0.73 Pain Relevance 0
Thus we examined MPO distribution in the retina by immunohistochemistry following nanoparticle treatment and we found no MPO immunoreactivity in the nanoparticle injected retinal sections.
Neg (no) Regulation (immunoreactivity) of MPO in retina associated with urological neuroanatomy
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.16 Pain Relevance 0.12
MPO immunoreactivity was markedly elevated in the positive controls (Figure 3B), but there was no detectable MPO signal in either saline or nanoparticle dosed retinas.
Regulation (immunoreactivity) of MPO in retinas associated with urological neuroanatomy
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 1.10 Pain Relevance 0.12
MPO values were significantly higher in DSS-treated groups than corresponding controls at all the periods studied.
Regulation (values) of MPO associated with urological neuroanatomy
12) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.88 Pain Relevance 0.18
The development of intestinal lesions as induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of myeloperoxidase associated with urological neuroanatomy
13) Confidence 0.06 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075458 Disease Relevance 0.39 Pain Relevance 0.21
The development of intestinal lesions induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Regulation (regulation) of myeloperoxidase associated with urological neuroanatomy
14) Confidence 0.05 Published 2010 Journal Clin. Chim. Acta Section Abstract Doc Link 20074562 Disease Relevance 0.39 Pain Relevance 0.30

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