INT58338

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.13
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
monocytes 2
microglia 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 31 100.00 Very High Very High Very High
Glutamate 30 100.00 Very High Very High Very High
noradrenaline 4 99.98 Very High Very High Very High
dexamethasone 49 99.80 Very High Very High Very High
cytokine 67 99.78 Very High Very High Very High
Inflammation 79 99.60 Very High Very High Very High
rheumatoid arthritis 7 99.60 Very High Very High Very High
Enkephalin 3 98.44 Very High Very High Very High
tetrodotoxin 7 97.80 Very High Very High Very High
Pain 15 93.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 83 99.60 Very High Very High Very High
Rheumatoid Arthritis 15 99.60 Very High Very High Very High
Heat Stroke 114 96.08 Very High Very High Very High
Pain 16 93.84 High High
Cv General 4 Under Development 24 93.56 High High
Shock 7 92.80 High High
Cancer 28 75.00 Quite High
Leukemia 2 73.12 Quite High
Stress 51 68.80 Quite High
Hypoxia 3 60.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
Negative_regulation (reduced) of Localization (releasing) of IL-1 associated with dexamethasone
1) Confidence 0.25 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
Negative_regulation (inhibited) of Localization (release) of IL-1-induced associated with dexamethasone
2) Confidence 0.19 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
Phenytoin attenuated by approximately 50% the release of IL-1 alpha, IL-1 beta, and TNF-alpha from LPS-stimulated microglia, but had minimal effects on the release of IL-2, IL-4, IL-6, IL-10, MCP-1, and TGF-alpha.
Negative_regulation (attenuated) of Localization (release) of IL-1 alpha in microglia
3) Confidence 0.09 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.71
Furthermore, we also attempt to ascertain whether the neuroprotective effects of the combined agent treatment are associated with inhibition of cerebral release of glutamate, DA, 5-HT, hydroxyl radicals, and the serum IL-1?
Spec (whether) Negative_regulation (inhibition) of Localization (release) of IL-1 associated with dopamine and glutamate
4) Confidence 0.05 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2959042 Disease Relevance 0.74 Pain Relevance 0.28
In vitro treatment of RA monocytes with eCT reduced predominantly the EC release of both IL-1 alpha and IL-1 beta.
Negative_regulation (reduced) of Localization (release) of IL-1 alpha in monocytes associated with rheumatoid arthritis
5) Confidence 0.03 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8275585 Disease Relevance 0.64 Pain Relevance 0.64
IL-1 inhibits TSH secretion (718).
Negative_regulation (inhibits) of Localization (secretion) of IL-1
6) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.35 Pain Relevance 0.06
Dexamethasone and noradrenaline suppressed secretion of IL-2, IFN alpha, IFN gamma, TNF alpha, IL-1 alpha and IL-1 beta. beta-Endorphin and Leu-Enkephalin had no significant influence on cytokine secretion.
Negative_regulation (suppressed) of Localization (secretion) of IL-1 alpha associated with noradrenaline, enkephalin, dexamethasone and cytokine
7) Confidence 0.02 Published 1997 Journal Eur. J. Cancer Section Abstract Doc Link 9389931 Disease Relevance 0.07 Pain Relevance 0.71
First, it is considered to be the most powerful anti-inflammatory cytokine, potently downregulating TNF, IL-1 and IL-6 production and release [19,29,33].
Negative_regulation (downregulating) of Localization (release) of IL-1 associated with inflammation and cytokine
8) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079940 Disease Relevance 1.17 Pain Relevance 1.13

General Comments

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