INT58365

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 44.14
Pain Relevance 7.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LTF) extracellular region (LTF) cytoplasm (LTF)
Anatomy Link Frequency
neutrophils 5
feces 2
T-cell 2
plasma 1
exocrine pancreas 1
LTF (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 11 100.00 Very High Very High Very High
Morphine 824 99.54 Very High Very High Very High
Inflammation 288 99.14 Very High Very High Very High
spastic colon 151 99.08 Very High Very High Very High
Chronic pancreatitis 4 97.56 Very High Very High Very High
ganglionectomy 33 97.12 Very High Very High Very High
opioid receptor 168 93.92 High High
cytokine 26 91.60 High High
headache 9 87.92 High High
Inflammatory marker 10 87.08 High High
Disease Link Frequency Relevance Heat
Disease 1231 100.00 Very High Very High Very High
Lymphatic Filariasis 818 100.00 Very High Very High Very High
Infection 568 100.00 Very High Very High Very High
Syndrome 52 100.00 Very High Very High Very High
Schistosomiasis 29 100.00 Very High Very High Very High
Dengue 389 99.92 Very High Very High Very High
Onchocerciasis 67 99.76 Very High Very High Very High
Inflammatory Bowel Disease 713 99.70 Very High Very High Very High
Lymphedema 255 99.52 Very High Very High Very High
Worm Infection 13 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LF expression is greatly upregulated during neurodegenerative disorders and in elderly brains.
Gene_expression (expression) of LF in brains associated with neurodegenerative disease
1) Confidence 0.78 Published 2005 Journal Neurol. Neurochir. Pol. Section Abstract Doc Link 16355306 Disease Relevance 0.50 Pain Relevance 0.11
Immunohistochemical detection of lactoferrin in different human glandular tissues with special reference to the exocrine pancreas.
Gene_expression (detection) of lactoferrin in exocrine pancreas
2) Confidence 0.78 Published 1993 Journal Acta Histochem. Section Title Doc Link 8279235 Disease Relevance 0.32 Pain Relevance 0.10
We detected lactoferrin in the glands of parotis and mammae as well as of their secretions.
Gene_expression (detected) of lactoferrin in glands
3) Confidence 0.78 Published 1993 Journal Acta Histochem. Section Abstract Doc Link 8279235 Disease Relevance 0.35 Pain Relevance 0.11
Lactotransferrin (or lactoferrin), cathelicidin (or LL-37) and the defensins are all present in mucosal secretions, are produced at high levels by neutrophils, and have all been shown to have antiviral (especially anti-HIV) activity [32], [33], [34], [35], [36].
Gene_expression (present) of lactoferrin in neutrophils associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.69 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.25 Pain Relevance 0
Lactotransferrin (or lactoferrin), cathelicidin (or LL-37) and the defensins are all present in mucosal secretions, are produced at high levels by neutrophils, and have all been shown to have antiviral (especially anti-HIV) activity [32], [33], [34], [35], [36].
Gene_expression (present) of Lactotransferrin in neutrophils associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.69 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.26 Pain Relevance 0
We then used TaqMan real-time PCR primers to validate a subset of candidate classification genes. including the group of neutrophil-derived anti-microbial peptides that may be correlated with DHF responses (Figure 3) We found that expression of lactotransferrin and defensin alpha 1/3 was significantly higher in DHF patients relative to both DF and DSS patients.
Gene_expression (expression) of lactotransferrin in neutrophil associated with dengue and dengue hemorrhagic fever
6) Confidence 0.69 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 2.02 Pain Relevance 0.04
We noted with interest that Long et al. [9] also observed a significantly higher expression of LTF, DEFA3 and DEFA4 in patient samples with DSS [9].
Gene_expression (expression) of LTF associated with dengue hemorrhagic fever
7) Confidence 0.69 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 0.80 Pain Relevance 0
The immunohistochemical detection of lactoferrin was carried out with the PAP technique on pancreatic tissue samples of 23 patients, operated for acute (13) or chronic (4) pancreatitis as well as for adenocarcinomas (6).
Gene_expression (detection) of lactoferrin associated with adenocarcinoma and pancreatitis
8) Confidence 0.67 Published 1993 Journal Acta Histochem. Section Abstract Doc Link 8279235 Disease Relevance 0.30 Pain Relevance 0.03
We would like to interpret our results with the hypothesis of granulocytic origin of immunochemically detectable lactoferrin in the pancreatic juice of patients, especially in cases of chronic pancreatitis.
Gene_expression (detectable) of lactoferrin associated with chronic pancreatitis
9) Confidence 0.60 Published 1993 Journal Acta Histochem. Section Abstract Doc Link 8279235 Disease Relevance 0.44 Pain Relevance 0.14
Lactotransferrin (or lactoferrin), cathelicidin (or LL-37) and the defensins are all present in mucosal secretions, are produced at high levels by neutrophils, and have all been shown to have antiviral (especially anti-HIV) activity [32], [33], [34], [35], [36].
Gene_expression (produced) of Lactotransferrin in neutrophils associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.53 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.28 Pain Relevance 0
Lactotransferrin (or lactoferrin), cathelicidin (or LL-37) and the defensins are all present in mucosal secretions, are produced at high levels by neutrophils, and have all been shown to have antiviral (especially anti-HIV) activity [32], [33], [34], [35], [36].
Gene_expression (produced) of lactoferrin in neutrophils associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.53 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.27 Pain Relevance 0
Therefore, LF was expected to be lost during protein precipitation.
Gene_expression (expected) of LF
12) Confidence 0.52 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0 Pain Relevance 0
Stability: LF was stable in plasma at the tested conditions, and LF stock solution was stable for at least 9 months in ?
Gene_expression (stable) of LF in plasma
13) Confidence 0.46 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 0.07 Pain Relevance 0
Lumefantrine (LF), also named benflumetol and chemically (9z)-2,7-dichloro-9-[(4-chlorophenyl) methylene]-a-[(dibutylamino)methyl]-9H-fluorene-4-methanol, is an aryl alcohol antimalarial first synthesized in the 1970’s by the Academy of Military Medical Sciences, Beijing, China and registered in China for the treatment of malaria in 1987.2 The compound is a yellow powder that is poorly soluble in water, oils, and most organic solvents, but soluble in unsaturated fatty acids and acidified organic solvents.
Gene_expression (synthesized) of LF associated with malaria and alcohol
14) Confidence 0.41 Published 2010 Journal Analytical Chemistry Insights Section Body Doc Link PMC2865164 Disease Relevance 1.13 Pain Relevance 0.14
The information presented here indicates that helminth infections, especially the three major STH infections, schistosomiasis, LF, and onchocerciasis, account for up to 85% of the disease burden caused by NTDs in SSA (Table 6).
Gene_expression (infections) of LF associated with onchocerciasis, lymphatic filariasis, worm infection, disease, schistosomiasis and infection
15) Confidence 0.32 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2727001 Disease Relevance 3.20 Pain Relevance 0
Statistical evaluation of HRV spectral features, areas of LF or HF regions, and LF/HF ratios, showed no effect of daily exposures to IH in either RSGX or SHAM treatment groups, neither was there any effect of passage of time on HRV spectra of CON animals.
Gene_expression (regions) of LF associated with hypoxia and ganglionectomy
16) Confidence 0.19 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1523191 Disease Relevance 0.23 Pain Relevance 0.18
Furthermore, high coverage rates in areas undergoing MDA allow a subgroup of untreated individuals to be protected from infection, subsequent clinical disease, and the incurrence of economic costs as a result of reduced rates of LF transmission.
Gene_expression (transmission) of LF associated with lymphatic filariasis, disease and infection
17) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.10 Pain Relevance 0
The study found that fecal lactoferrin was 90% specific for identifying inflammation in patients with active IBD, and elevated levels of lactoferrin were 100% specific in ruling out IBS.43
Gene_expression (fecal) of lactoferrin associated with inflammatory bowel disease, inflammation and spastic colon
18) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.99 Pain Relevance 0.79
Fecal lactoferrin was found to be significantly higher in active IBD than in inactive IBD, IBS and infectious bowel disease.
Gene_expression (higher) of lactoferrin in bowel associated with inflammatory bowel disease, spastic colon and enteropathy
19) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.81 Pain Relevance 0.58
Lactoferrin can be detected using simple and inexpensive techniques since it has an excellent stability in the feces for 4 days since a commercial ELISA has been developed and is now widely available.
Gene_expression (detected) of Lactoferrin in feces
20) Confidence 0.15 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.21 Pain Relevance 0.29

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