INT58380

Context Info Confidence 0.47 First Reported 1993 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 13 Total Number 13 Disease Relevance 9.87 Pain Relevance 2.44

cytosol (ALAD) small molecule metabolic process (ALAD) lyase activity (ALAD)

Anatomy Link Frequency blood 1 immune system 1 stomach 1 ALAD (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 14 99.84 peptic ulcer disease 19 99.36 nud 3 96.68 Inflammation 3 87.56 aspirin 2 80.64 cytokine 1 25.00

Disease Link Frequency Relevance Heat Gastritis 38 100.00 Ulcers 33 100.00 Disease 26 99.68 Infection 15 99.04 Iron-deficiency Anemia 3 98.32 Carcinoma 1 98.24 Gastrointestinal Disease 1 96.96 Dyspepsia 2 96.68 Stomach Cancer 5 96.40 Atrophic Gastritis 1 95.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Pretreatment with Tween detergents also inhibited H. pylori receptor binding by up to 80% at concentrations as low as 0.0001%.

H. pylori Binding (binding) of

1) Confidence 0.47 Published 1993 Journal Zentralbl. Bakteriol. Section Abstract Doc Link 8280948 Disease Relevance 0.47 Pain Relevance 0.07

Persistence is achieved through initial interactions between H. pylori adhesins and cellular receptors, after which H. pylori must avoid clearance by the immune system.

H. pylori Binding (interactions) of in immune system

2) Confidence 0.47 Published 2006 Journal Curr. Opin. Gastroenterol. Section Body Doc Link 16319669 Disease Relevance 0 Pain Relevance 0

Clinical outcomes of H. pylori infection has been shown to depend on the variability of H. pylori virulence factors, host susceptibility, environmental factors and their interactions.

H. pylori Binding (interactions) of associated with infection

3) Confidence 0.47 Published 2005 Journal Korean J Gastroenterol Section Abstract Doc Link 16179837 Disease Relevance 0.91 Pain Relevance 0.09

Existing evidence indicates that the interaction between H. pylori and NSAIDs is not an 'all-or-none' relationship.

H. pylori Binding (interaction) of associated with cinod

4) Confidence 0.47 Published 2000 Journal Baillieres Best Pract Res Clin Gastroenterol Section Abstract Doc Link 10749096 Disease Relevance 0.65 Pain Relevance 1.00

Although there is some association between Hp positivity and chronic active gastritis and carcinoma of the stomach, there is at present no indication for diagnosis of Hp, as treatment of the infection has not proved effective in reversing atrophy or dysplasia. 3.

Hp Binding (association) of in stomach associated with cleidocranial dysplasia, frailty, carcinoma, gastritis and infection

5) Confidence 0.47 Published 2000 Journal Ugeskr. Laeg. Section Abstract Doc Link 10925639 Disease Relevance 2.48 Pain Relevance 0.38

We compared H. pylori SS1 sonicate (LPS+) to a sonicate depleted of LPS (LPS-) in immunized BALB/c mice.

H. pylori Binding (compared) of

6) Confidence 0.36 Published 2006 Journal Vaccine Section Abstract Doc Link 16621176 Disease Relevance 0.62 Pain Relevance 0.09

The aim of this study is to investigate H. pylori-related changes in gastric physiology and histology and the relationship of these changes to iron deficiency anemia in children.

H. pylori- Binding (investigate) of associated with iron-deficiency anemia

7) Confidence 0.36 Published 2004 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 14734875 Disease Relevance 0.97 Pain Relevance 0.09

CONCLUSION: In children, H. pylori-related PUD is associated with familial peptic ulcer and the presence of DU.

H. pylori- Binding (associated) of

8) Confidence 0.36 Published 2010 Journal J. Formos. Med. Assoc. Section Body Doc Link 20123589 Disease Relevance 0 Pain Relevance 0

Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.

Helicobacter pylori Binding (binding) of in blood associated with ulcers

9) Confidence 0.35 Published 1998 Journal Science Section Title Doc Link 9430586 Disease Relevance 0.39 Pain Relevance 0.10

This is in contrast to adults with gastritis or peptic ulcer disease (or both), in whom most of the H. pylori isolates bind Le(b).

H. pylori Binding (bind) of associated with peptic ulcer disease, disease and gastritis

10) Confidence 0.35 Published 1998 Journal J. Infect. Dis. Section Abstract Doc Link 9419200 Disease Relevance 0.69 Pain Relevance 0.18

H. pylori binds FGF with an extremely strong affinity (3.8 x 10(-12)M), and also heparan sulfate and heparin with higher affinity (Kd 9 x 10(-9)M) than FGFs bind to heparin (10(-8) - 10(-9)M).

H. pylori Binding (bind) of

11) Confidence 0.35 Published 1995 Journal FEMS Immunol. Med. Microbiol. Section Abstract Doc Link 8745013 Disease Relevance 0.53 Pain Relevance 0.09

Although a number of putative virulence factors have been reported for H. pylori, there are conflicting results regarding their association with specific H. pylori-related diseases.

H. pylori- Binding (association) of associated with disease

12) Confidence 0.35 Published 2008 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 18560912 Disease Relevance 1.57 Pain Relevance 0.22

Numerous studies published in the last year provided new insight into H. pylori virulence factors, their interaction with the host and consequences in pathogenesis.

H. pylori Binding (interaction) of

13) Confidence 0.35 Published 2009 Journal Helicobacter Section Abstract Doc Link 19712163 Disease Relevance 0.60 Pain Relevance 0.14

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