INT5839

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 11.61
Pain Relevance 6.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
hippocampus 5
eyes 4
retina 4
neuronal 2
striatum 1
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 400 100.00 Very High Very High Very High
Neuropathic pain 31 99.84 Very High Very High Very High
midbrain 4 99.16 Very High Very High Very High
Hippocampus 8 98.76 Very High Very High Very High
depression 2 96.76 Very High Very High Very High
Inflammation 18 96.28 Very High Very High Very High
tetrodotoxin 2 91.88 High High
Eae 5 91.24 High High
Central grey 6 89.20 High High
allodynia 7 83.48 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 288 100.00 Very High Very High Very High
Neuropathic Pain 38 99.84 Very High Very High Very High
Injury 102 98.88 Very High Very High Very High
Convulsion 18 98.82 Very High Very High Very High
Epilepsy 6 97.12 Very High Very High Very High
Depression 2 96.76 Very High Very High Very High
INFLAMMATION 18 96.28 Very High Very High Very High
Retina Disease 116 96.24 Very High Very High Very High
Death 24 89.60 High High
Urological Neuroanatomy 6 89.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.
Positive_regulation (increased) of Transcription (levels) of glial fibrilary acidic protein associated with neuropathic pain
1) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.98 Pain Relevance 1.60
For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.
Positive_regulation (increased) of Transcription (levels) of GFAP associated with neuropathic pain
2) Confidence 0.49 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.98 Pain Relevance 1.60
GeneChips, RT-PCR and Western blotting revealed the select up-regulation in translation and transcription of glial fibrillary acidic protein (GFAP) and Vimentin in rats with Persistent Disability.
Positive_regulation (up-regulation) of Transcription (transcription) of GFAP
3) Confidence 0.46 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.33 Pain Relevance 0.98
The increases in GFAP mRNA levels are not in response to decreases in neuronal activity (as a result of postictal depression), because GFAP mRNA levels are unaffected when neuronal activity is decreased by blocking afferent drive (with tetrodotoxin).
Positive_regulation (increases) of Transcription (levels) of GFAP in neuronal associated with tetrodotoxin and depression
4) Confidence 0.46 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.14
If seizures are induced repetitively (every other day for many days), levels of GFAP mRNA remain elevated.
Positive_regulation (elevated) of Transcription (levels) of GFAP associated with convulsion
5) Confidence 0.46 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.11
An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.
Positive_regulation (increase) of Transcription (associated) of GFAP in hippocampus associated with hippocampus and midbrain
6) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29
In the present study, GFAP mRNA levels increased in the retinas subjected to ischemia-reperfusion, indicating that an insult that triggers a molecular response had indeed taken place.
Positive_regulation (increased) of Transcription (levels) of GFAP in retinas associated with ischemia
7) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.10 Pain Relevance 0.35
GFAP mRNA expression levels were higher in the neuroretinas from ischemia-reperfusion eyes than from sham-operated eyes and increased gradually with increasing duration of reperfusion (Figure 3).


Positive_regulation (increased) of Transcription (expression) of GFAP in eyes associated with ischemia
8) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.39 Pain Relevance 0.20
GFAP mRNA expression levels were higher in the neuroretinas from ischemia-reperfusion eyes than from sham-operated eyes and increased gradually with increasing duration of reperfusion (Figure 3).


Positive_regulation (increased) of Transcription (levels) of GFAP in eyes associated with ischemia
9) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.39 Pain Relevance 0.20
The present animal model produced ischemic injury to the retina as verified by the presence of pyknotic cell nuclei, TUNEL-labeled cells, and increased GFAP mRNA levels.
Positive_regulation (increased) of Transcription (levels) of GFAP in retina associated with injury
10) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.18 Pain Relevance 0.42
An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.
Positive_regulation (increase) of in midbrain Transcription (associated) of GFAP in hippocampus associated with hippocampus and midbrain
11) Confidence 0.15 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29
An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.
Positive_regulation (increase) of in striatum Transcription (associated) of GFAP in hippocampus associated with hippocampus and midbrain
12) Confidence 0.15 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29
An examination of the specific regions of the brain revealed an increase in GFAP mRNA associated with the forebrain, midbrain, hippocampus and striatum.
Positive_regulation (increase) of in forebrain Transcription (associated) of GFAP in hippocampus associated with hippocampus and midbrain
13) Confidence 0.15 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1317493 Disease Relevance 0.28 Pain Relevance 0.29

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