INT58390

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Context Info
Confidence 0.21
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 14.40
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
d cells 8
endothelial cell 6
fibroblast 4
chondrocytes 2
plasma 2
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 10 99.88 Very High Very High Very High
antagonist 5 98.48 Very High Very High Very High
cINOD 84 98.24 Very High Very High Very High
Opioid 4 98.04 Very High Very High Very High
metalloproteinase 1034 96.92 Very High Very High Very High
MU agonist 4 91.96 High High
COX-2 inhibitor 245 90.16 High High
fibrosis 22 84.36 Quite High
cytokine 817 83.12 Quite High
Osteoarthritis 38 79.52 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 2380 100.00 Very High Very High Very High
Infection 1090 100.00 Very High Very High Very High
Injury 28 99.56 Very High Very High Very High
Adhesions 423 99.16 Very High Very High Very High
Anaplastic Astrocytoma 5 99.00 Very High Very High Very High
INFLAMMATION 592 98.12 Very High Very High Very High
Death 38 96.32 Very High Very High Very High
Apoptosis 176 95.88 Very High Very High Very High
Cancer 262 94.88 High High
Birth Weight 23 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS-induced IL-6 and PGE2 release was only slightly inhibited at high doses, whereas LPS-induced release of IL-8 and matrix metalloprotease (MMP)-9 was not affected.
Negative_regulation (inhibited) of Localization (release) of PGE2
1) Confidence 0.21 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515409 Disease Relevance 0.50 Pain Relevance 0.19
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Negative_regulation (reduced) of Localization (secretion) of PGE2
2) Confidence 0.18 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.69 Pain Relevance 0.41
In addition, DEX reduced the IL-1beta induced COX-2 immunoreactivity in the same concentration as wherein it inhibited PGE2 secretion.
Negative_regulation (inhibited) of Localization (secretion) of PGE2 associated with dexamethasone
3) Confidence 0.16 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.75 Pain Relevance 0.45
In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.
Spec (determine) Negative_regulation (inhibition) of Localization (release) of PGE2 in fibroblast
4) Confidence 0.13 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.27 Pain Relevance 0.10
In an assay to determine inhibition of the H2O2-activated release of PGE2, IL-6, and IL-8 in human normal fibroblast cell lines, the release of PGE2 and IL-6 was almost completely inhibited above concentrations of 0.05% and 1%, respectively.
Negative_regulation (inhibited) of Localization (release) of PGE2 in fibroblast
5) Confidence 0.13 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.25 Pain Relevance 0.10
IND significantly reduced both basal and IL-1 beta-induced PGE2 release and HGF production.
Negative_regulation (reduced) of Localization (release) of PGE2 in HGF
6) Confidence 0.09 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9571196 Disease Relevance 0.23 Pain Relevance 0.36
Dexamethasone also inhibited the PGE2 release from the astrocytes and astroglioma cells, however the inhibitory effect of dexamethasone on the IL-1beta-activated IL-6 release could not be prevented by the addition of PGE2.
Negative_regulation (inhibited) of Localization (release) of PGE2 in astrocytes associated with anaplastic astrocytoma and dexamethasone
7) Confidence 0.08 Published 1997 Journal Brain Res. Section Abstract Doc Link 9449430 Disease Relevance 0.59 Pain Relevance 0.30
Consistent with a significant decrease in PGE2 secretion by MDA-MB-231 cells after celecoxib treatment [15], we observed a twofold decrease in prostaglandin E synthase 2 (Figure 4), which is the enzyme involved in the synthesis of PGE2.
Negative_regulation (decrease) of Localization (secretion) of PGE2 in MDA-MB-231
8) Confidence 0.06 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.41 Pain Relevance 0.13
induced PGE2 secretion was reduced drastically in si-COX-2- HMVEC-d cells (Figure 3B) suggesting that COX-2 silencing could effectively abrogate KSHV infection induced PGE2 secretion in endothelial cells.
Negative_regulation (reduced) of Localization (secretion) of PGE2 in d cells associated with herpes simplex virus and infection
9) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.24 Pain Relevance 0
COX-2 silencing reduces COX-2 gene expression and PGE2 secretion in HMVEC-d cells
Negative_regulation (reduces) of Localization (secretion) of PGE2 in d cells
10) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.74 Pain Relevance 0.21
TIVE-LTC cells pretreated with nontoxic doses of either Indo (500 µM or 250 µM) or NS-398 (50 µM or 75 µM) at 37°C for 1h did not completely inhibit PGE2 secretion (Figure S4).
Negative_regulation (inhibit) of Localization (secretion) of PGE2
11) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.41 Pain Relevance 0
To understand the role of COX-2 inhibition and abrogated secretion of PGE2 in endothelial cell adhesion, we used the supernatant obtained from the cells pretreated with NS-398 and then infected with KSHV.
Negative_regulation (abrogated) of Localization (secretion) of PGE2 in endothelial cell associated with herpes simplex virus and adhesions
12) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.28 Pain Relevance 0
Previously, we have shown that pretreatment of HMVEC-d cells with NS-398 inhibited the secretion of PGE2, suggesting that these supernatants would be depleted of PGE2.
Negative_regulation (inhibited) of Localization (secretion) of PGE2 in d cells
13) Confidence 0.05 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.86 Pain Relevance 0
The inhibition by COX inhibitors of PGE2 release following trauma may provide an opportunity for early clinical intervention to reduce cell death from apoptosis.
Negative_regulation (inhibitors) of Localization (release) of PGE2 associated with injury, apoptosis and death
14) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 1.01 Pain Relevance 0.40
The release of PGE2 by articular chondrocytes and its inhibition by indomethacin is well established [40].
Negative_regulation (inhibition) of Localization (release) of PGE2 in chondrocytes
15) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246251 Disease Relevance 0.37 Pain Relevance 0.03
First, we determined the concentrations of COX inhibitors affecting PGE2 secretion.
Negative_regulation (inhibitors) of Localization (secretion) of PGE2
16) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.39 Pain Relevance 0.03
Pre-treatment of endothelial cells with chemical nonsteroidal anti-inflammatory drugs (N SAID) like Indo or COX-2 selective inhibitor (COXIB) NS-398 prior to KSHV infection abrogated the secretion of PGE2 [26].
Negative_regulation (abrogated) of Localization (secretion) of PGE2 in endothelial cells associated with inflammation, herpes simplex virus, cinod and infection
17) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.84 Pain Relevance 0.24
This requirement for a higher dose of inhibitors to block COX-2 function and PGE2 secretion could be due to the continuous loop of COX activation leading to the maintenance of a constant level of PGE2 in latently infected cells.
Negative_regulation (block) of Localization (secretion) of PGE2
18) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.49 Pain Relevance 0
Silencing of COX-2 reduces KSHV infection induced COX-2 gene expression and PGE2 secretion in HMVEC-d cells
Negative_regulation (reduces) of Localization (secretion) of PGE2 in d cells associated with herpes simplex virus and infection
19) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.34 Pain Relevance 0
KSHV infection induced PGE2 secretion regulates endothelial cell adhesion
Negative_regulation (infection) of Localization (secretion) of PGE2 in endothelial cell associated with herpes simplex virus, adhesions and infection
20) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.16 Pain Relevance 0

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