INT58392

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 5.18
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
endothelial cell 4
PGE2 2
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 204 100.00 Very High Very High Very High
Osteoarthritis 39 99.16 Very High Very High Very High
cINOD 31 95.60 Very High Very High Very High
antagonist 1 94.72 High High
Opioid 2 94.28 High High
Pain 3 93.40 High High
MU agonist 2 88.20 High High
aspirin 6 88.00 High High
dexamethasone 3 85.56 High High
COX2 4 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 228 100.00 Very High Very High Very High
Infection 416 99.82 Very High Very High Very High
Herpes Simplex Virus 952 99.62 Very High Very High Very High
Adhesions 168 99.28 Very High Very High Very High
Osteoarthritis 51 99.16 Very High Very High Very High
Toxicity 1 98.48 Very High Very High Very High
Hypersensitivity 2 96.48 Very High Very High Very High
Fever 2 93.80 High High
Pain 3 93.40 High High
Ulcers 2 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of PGE2 release
Regulation (Quantification) of Localization (release) of PGE2
1) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.10 Pain Relevance 0.05
This suggests that the IL-1beta induced PGE2 secretion may depend on the availability of arachidonic acid.
Spec (may) Regulation (depend) of Localization (secretion) of PGE2
2) Confidence 0.12 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.67 Pain Relevance 0.39
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Regulation (anti) of Localization (release) of PGE2 associated with inflammation
3) Confidence 0.10 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.62 Pain Relevance 0.21
In order to investigate the possibility of Crinum asiaticum Linne var. japonicum extract as a cosmetic ingredient, we measured its anti-inflammatory effect by its inhibition of iNOS (inducible nitric oxide synthase) and the release of PGE2, IL-6, and IL-8.
Regulation (effect) of Localization (release) of PGE2 associated with inflammation
4) Confidence 0.10 Published 2008 Journal J Cosmet Sci Section Abstract Doc Link 18841306 Disease Relevance 0.62 Pain Relevance 0.21
Finally, neither sodium nitroprusside nor zaprinast (both of which elevate cGMP levels) affected GM-CSF or PGE2 release.
Neg (nor) Regulation (affected) of Localization (release) of PGE2 in PGE2
5) Confidence 0.09 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15680249 Disease Relevance 0.10 Pain Relevance 0.88
KSHV infection induced PGE2 secretion regulates endothelial cell adhesion
Regulation (regulates) of Localization (secretion) of PGE2 in endothelial cell associated with herpes simplex virus, adhesions and infection
6) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.16 Pain Relevance 0
To understand the role of COX-2 inhibition and abrogated secretion of PGE2 in endothelial cell adhesion, we used the supernatant obtained from the cells pretreated with NS-398 and then infected with KSHV.
Regulation (role) of Localization (secretion) of PGE2 in endothelial cell associated with herpes simplex virus and adhesions
7) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.30 Pain Relevance 0
This suggested that PGE2 secretion plays an important role in Rac1 stimulation, which was further supported by the 2.4-fold activity of Rac1 in the lysates prepared from cells plated in the presence of PGE2 alone for 30?
Regulation (role) of Localization (secretion) of PGE2
8) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0 Pain Relevance 0
First, we determined the concentrations of COX inhibitors affecting PGE2 secretion.
Regulation (affecting) of Localization (secretion) of PGE2
9) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.39 Pain Relevance 0.03
B inhibitor Bay, in contrast to mPGES-1 and COX-2 expression, may be a toxic effect of the inhibitor, affecting the release of PGE2 although no visual signs of cellular toxicity were observed.
Regulation (affecting) of Localization (release) of PGE2 associated with toxicity
10) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.23 Pain Relevance 0.04
In this area Diallyl-G had no effect on the PGE2 release but blocked the GnRH secretion.
Neg (no) Regulation (effect) of Localization (release) of PGE2
11) Confidence 0.01 Published 1993 Journal Brain Res. Section Abstract Doc Link 8281433 Disease Relevance 0 Pain Relevance 0.37

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