INT58400

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Context Info
Confidence 0.59
First Reported 1993
Last Reported 2010
Negated 1
Speculated 7
Reported most in Abstract
Documents 182
Total Number 190
Disease Relevance 129.97
Pain Relevance 71.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
plasma 13
brain 7
spinal cord 4
neutrophil 3
blood 3
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 713 100.00 Very High Very High Very High
cytokine 573 100.00 Very High Very High Very High
Neuropathic pain 78 100.00 Very High Very High Very High
aspirin 43 100.00 Very High Very High Very High
Spinal cord 38 100.00 Very High Very High Very High
COX2 36 100.00 Very High Very High Very High
chemokine 30 100.00 Very High Very High Very High
Clonidine 32 99.98 Very High Very High Very High
noradrenaline 2 99.98 Very High Very High Very High
anesthesia 78 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 826 100.00 Very High Very High Very High
Cancer 376 100.00 Very High Very High Very High
Injury 265 100.00 Very High Very High Very High
Necrosis 238 100.00 Very High Very High Very High
Neuropathic Pain 172 100.00 Very High Very High Very High
Shock 28 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 19 100.00 Very High Very High Very High
Hypoglycemia 4 100.00 Very High Very High Very High
Gastric Regurgitation 2 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 31 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition.
Negative_regulation (inhibition) of TNF-alpha
1) Confidence 0.59 Published 2003 Journal Spine Section Title Doc Link 12897484 Disease Relevance 0 Pain Relevance 0.10
Tumor necrosis factor alpha inhibition also seemed to reduce these behaviors.
Negative_regulation (inhibition) of Tumor necrosis factor alpha
2) Confidence 0.59 Published 2003 Journal Spine Section Body Doc Link 12897484 Disease Relevance 0 Pain Relevance 0
Clinical trials must be performed in order to assess if there may be a clinical use for tumor necrosis factor alpha inhibition in the treatment of sciatica due to disc herniation.


Negative_regulation (inhibition) of tumor necrosis factor alpha
3) Confidence 0.59 Published 2003 Journal Spine Section Body Doc Link 12897484 Disease Relevance 0 Pain Relevance 0
OBJECTIVES: To assess if selective inhibition of tumor necrosis factor alpha may reduce changes in spontaneous behavior induced by experimental disc herniation in the rat as previously reported.
Negative_regulation (inhibition) of tumor necrosis factor alpha
4) Confidence 0.59 Published 2003 Journal Spine Section Body Doc Link 12897484 Disease Relevance 0.10 Pain Relevance 0
We observed a dose-dependent decrease of TNF-alpha mRNA in the hepatocytes, and of TNF-alpha release into the medium of hepatocyte cultures.
Negative_regulation (decrease) of TNF-alpha in hepatocyte
5) Confidence 0.59 Published 1999 Journal Toxicology Section Abstract Doc Link 10378475 Disease Relevance 0.23 Pain Relevance 0.47
Pentoxifylline dose dependently reduced both gastric damage and plasma TNF-alpha.
Negative_regulation (reduced) of TNF-alpha in plasma
6) Confidence 0.59 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8772499 Disease Relevance 0.56 Pain Relevance 0.52
These results indicate that the protective effect by ghrelin in the spinal cord is mediated through the suppression of TNF-alpha and IL-1beta.
Negative_regulation (suppression) of TNF-alpha in spinal cord associated with spinal cord
7) Confidence 0.58 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20561937 Disease Relevance 0.75 Pain Relevance 0.95
Serum and local TNF-alpha levels were suppressed in treated animals whereas there were little changes in interleukin-1beta levels.
Negative_regulation (suppressed) of TNF-alpha
8) Confidence 0.58 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10884526 Disease Relevance 1.20 Pain Relevance 0.77
Tumor necrosis factor-alpha in the brain tissue was significantly elevated in the ischemic hemisphere 6 h after reperfusion in the nonspecific IgG-treated rats (P=0.021, n=7) and was decreased in the antitumor necrosis factor-alpha neutralizing antibody-treated rats (P=0.001, n=7).
Negative_regulation (decreased) of antitumor necrosis factor-alpha in brain associated with necrosis and cancer
9) Confidence 0.58 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.17 Pain Relevance 0.47
In the antitumor necrosis factor-alpha neutralizing antibody-treated rats, infarct volume was significantly reduced (P=0.014, n=7; respectively), and cerebral specific gravity was dramatically increased in the cortex and caudate putamen (P<0.001, n=7; respectively) in association with a reduction in MMP-9 and membrane type 1-MMP upregulation.
Negative_regulation (reduced) of antitumor necrosis factor-alpha in caudate putamen associated with necrosis and metalloproteinase
10) Confidence 0.58 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.63 Pain Relevance 0.55
Treatment with sirolimus resulted in antihyperalgesic and antiallodynic effects and prevented the increased spinal cord TNF-alpha level.
Negative_regulation (prevented) of TNF-alpha in spinal cord associated with antihyperalgesic, antiallodynic and spinal cord
11) Confidence 0.58 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20600616 Disease Relevance 1.06 Pain Relevance 1.37
It also significantly suppressed local tissue TNF-alpha and IL-1beta (p<0.05).
Negative_regulation (suppressed) of TNF-alpha
12) Confidence 0.58 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15970410 Disease Relevance 1.14 Pain Relevance 0.41
Thalidomide--removed from widespread clinical use by 1962 because of severe teratogenicity--has antiangiogenic and immunomodulatory effects, including the inhibition of tumor necrosis alpha factor.
Negative_regulation (inhibition) of tumor necrosis alpha factor associated with necrosis and cancer
13) Confidence 0.57 Published 2002 Journal Annu. Rev. Med. Section Abstract Doc Link 11818493 Disease Relevance 0.66 Pain Relevance 0
Role of TNF-alpha in high-dose antigen therapy in experimental autoimmune neuritis: inhibition of TNF-alpha by neutralizing antibodies reduces T-cell apoptosis and prevents liver necrosis.
Negative_regulation (inhibition) of TNF-alpha in T-cell associated with experimental autoimmune neuritis, hepatotoxicity, apoptosis and neuritis
14) Confidence 0.57 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Title Doc Link 10888366 Disease Relevance 1.32 Pain Relevance 0.62
This may indicate that inhibition of TNF-alpha exerts beneficial effects other than through T-cell apoptosis, or that some of the benefit of antigen therapy is mediated by other pathways.
Negative_regulation (inhibition) of TNF-alpha in T-cell associated with apoptosis
15) Confidence 0.57 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10888366 Disease Relevance 1.36 Pain Relevance 0.63
In conclusion, the anti-nociceptive activity of thalidomide in zymosan-induced articular incapacitation is associated with the inhibition of TNF-alpha by resident synovial cells.
Negative_regulation (inhibition) of TNF-alpha in articular associated with nociception
16) Confidence 0.57 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16597438 Disease Relevance 0.62 Pain Relevance 0.23
Therapeutic approaches such as the use of inhibitors of TNF-?
Negative_regulation (inhibitors) of TNF
17) Confidence 0.57 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 1.16 Pain Relevance 0.21
Thus, inhibition of TNF-?
Negative_regulation (inhibition) of TNF
18) Confidence 0.57 Published 2008 Journal Crit Care Section Body Doc Link PMC2575560 Disease Relevance 0.54 Pain Relevance 0.29
appears to have a significant role in the accumulation of intravascular macrophages in CBDL animal models; inhibition of TNF-?
Negative_regulation (inhibition) of TNF in macrophages
19) Confidence 0.57 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.86 Pain Relevance 0.04
Pentoxifylline is also an effective phosphodiesterase inhibitor showing anti-inflammatory and immunosuppressive effects due to suppression of TNF-?
Negative_regulation (suppression) of TNF associated with inflammation
20) Confidence 0.57 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.99 Pain Relevance 0.13

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