INT5842

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Context Info
Confidence 0.78
First Reported 1985
Last Reported 2011
Negated 11
Speculated 7
Reported most in Abstract
Documents 372
Total Number 380
Disease Relevance 153.71
Pain Relevance 127.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 41
spinal cord 22
brain 17
neuronal 14
spinal 12
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1773 100.00 Very High Very High Very High
Inflammation 1594 100.00 Very High Very High Very High
Pain 1277 100.00 Very High Very High Very High
Nerve growth factor 260 100.00 Very High Very High Very High
Neuropeptide 52 100.00 Very High Very High Very High
Somatostatin 25 100.00 Very High Very High Very High
Enkephalin 21 100.00 Very High Very High Very High
Cholecystokinin 5 100.00 Very High Very High Very High
Sciatic nerve 119 99.92 Very High Very High Very High
Chronic pancreatitis 37 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1826 100.00 Very High Very High Very High
Apoptosis 397 100.00 Very High Very High Very High
Cancer 277 100.00 Very High Very High Very High
Necrosis 67 100.00 Very High Very High Very High
Pancreatitis 41 99.92 Very High Very High Very High
Neuropathic Pain 2814 99.90 Very High Very High Very High
Hypersensitivity 726 99.90 Very High Very High Very High
Disorder Of Lipid Metabolism 6 99.88 Very High Very High Very High
Urological Neuroanatomy 378 99.84 Very High Very High Very High
Convulsion 149 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GFAP mRNA expression and immunoreactivity in the cochlear nucleus was qualitatively stronger than in the ipsilateral vestibular nuclei.
Gene_expression (expression) of GFAP mRNA in cochlear nucleus
1) Confidence 0.78 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.33
In contrast, a robust increase of the distribution and relative levels of GFAP mRNA expression, protein levels and immunoreactivity was observed in the deafferented vestibular and cochlear nuclei beginning at 1 day after inner ear lesion.
Gene_expression (expression) of GFAP mRNA in cochlear
2) Confidence 0.78 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.36
No significant changes in the distribution or relative levels of GFAP mRNA expression, relative levels of GFAP protein or immunoreactivity for GFAP were found in the ipsilateral vestibular nuclei at any post-TTX injection times studied.
Gene_expression (expression) of GFAP mRNA associated with tetrodotoxin
3) Confidence 0.78 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.40
In this study, we investigated whether changes in the vestibular neuronal activity per se influence the pattern of astrocytes morphology, glial fibrillary acidic protein (GFAP) expression and ultimately their activation within the vestibular nuclei after unilateral transtympanic tetrodotoxin (TTX) injections and after unilateral inner ear lesion.
Gene_expression (expression) of glial fibrillary acidic protein in neuronal associated with tetrodotoxin
4) Confidence 0.78 Published 2005 Journal Neuroscience Section Abstract Doc Link 15652984 Disease Relevance 0 Pain Relevance 0.34
The interpeduncular nucleus (IPN) of female rats was studied across the estrous cycle to observe whether the expression of the astroglial marker, glial fibrillary acidic protein (GFAP) reacts to hormonal changes in an area not belonging to the 'endocrine brain'.
Spec (whether) Gene_expression (expression) of glial fibrillary acidic protein in interpeduncular nucleus associated with ipn
5) Confidence 0.78 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799667 Disease Relevance 0 Pain Relevance 0.15
Since cyclic fluctuations of synaptic numbers in the female have been described only for the endocrine hypothalamus, decrease of immunoreactive GFAP in the IPN during estrus may reflect a down-regulation of GFAP synthesis.
Gene_expression (synthesis) of GFAP in hypothalamus associated with ipn
6) Confidence 0.78 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799667 Disease Relevance 0 Pain Relevance 0.17
The interpeduncular nucleus (IPN) of female rats was studied across the estrous cycle to observe whether the expression of the astroglial marker, glial fibrillary acidic protein (GFAP) reacts to hormonal changes in an area not belonging to the 'endocrine brain'.
Spec (whether) Gene_expression (expression) of GFAP in interpeduncular nucleus associated with ipn
7) Confidence 0.78 Published 2000 Journal Brain Res. Section Abstract Doc Link 10799667 Disease Relevance 0 Pain Relevance 0.15
Glial fibrillary acidic protein (GFAP) expressions in the thoracic spinal cord were observed by immunohistochemistry and real-time reverse transcription polymerase chain reaction (RT-PCR).
Gene_expression (expressions) of Glial fibrillary acidic protein in spinal cord associated with spinal cord
8) Confidence 0.78 Published 2010 Journal Neuroscience Section Abstract Doc Link 20149842 Disease Relevance 1.65 Pain Relevance 1.42
Hyperalgesia in response to traumatic occlusion and GFAP expression in rat parabrachial [correction of parabranchial] nucleus: modulation with fluorocitrate.
Gene_expression (expression) of GFAP in nucleus associated with hyperalgesia and parabrachial
9) Confidence 0.78 Published 2007 Journal Cell Tissue Res. Section Title Doc Link 17443351 Disease Relevance 0.39 Pain Relevance 0.35
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Gene_expression (expression) of glial fibrillary acidic protein in molars
10) Confidence 0.78 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.30 Pain Relevance 0.23
Real-time RT-PCR indicated that GFAP expression was significantly increased in TNBS treated rats compared to the sham group.
Gene_expression (expression) of GFAP
11) Confidence 0.78 Published 2010 Journal Neuroscience Section Abstract Doc Link 20149842 Disease Relevance 1.47 Pain Relevance 1.48
Glial fibrillary acidic protein (GFAP) expressions in the thoracic spinal cord were observed by immunohistochemistry and real-time reverse transcription polymerase chain reaction (RT-PCR).
Gene_expression (expressions) of GFAP in spinal cord associated with spinal cord
12) Confidence 0.78 Published 2010 Journal Neuroscience Section Abstract Doc Link 20149842 Disease Relevance 1.63 Pain Relevance 1.40
The expression of glial fibrillary acidic protein (GFAP) in PBN of ipsilateral and contralateral sides was up-regulated 4 h after occlusal changes in molars, reached peak levels at 24 h, and was then gradually down-regulated.
Gene_expression (expression) of GFAP in molars
13) Confidence 0.78 Published 2007 Journal Cell Tissue Res. Section Abstract Doc Link 17443351 Disease Relevance 0.30 Pain Relevance 0.23
Inverse relation between intensity of GFAP expression in the substantia gelatinosa and degree of chronic mechanical allodynia.
Gene_expression (expression) of GFAP in substantia gelatinosa associated with substantia gelatinosa and allodynia
14) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Title Doc Link 19383423 Disease Relevance 0.90 Pain Relevance 0.90
Moreover, it was found that neuropathic animals with a higher degree of mechanical allodynia had a lower intensity of GFAP expression in lamina II (substantia gelatinosa).
Gene_expression (expression) of GFAP in lamina associated with substantia gelatinosa, allodynia and neuropathic pain
15) Confidence 0.78 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19383423 Disease Relevance 0.99 Pain Relevance 1.08
GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid.
Gene_expression (expression) of GFAP protein
16) Confidence 0.78 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.24 Pain Relevance 0.22
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.
Gene_expression (expression) of GFAP in frontal cortex associated with urological neuroanatomy
17) Confidence 0.78 Published 2008 Journal Schizophr. Res. Section Title Doc Link 18585900 Disease Relevance 0.28 Pain Relevance 0.21
The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid).
Spec (whether) Gene_expression (expressions) of GFAP associated with fluoxetine
18) Confidence 0.78 Published 2008 Journal Schizophr. Res. Section Abstract Doc Link 18585900 Disease Relevance 0.27 Pain Relevance 0.22
The effects of the treatments on GFAP expression were studied by immunohistochemical staining in Locus Coeruleus (LC) and Nucleus of the Solitary Tract (NST), two important noradrenergic nuclei.
Gene_expression (expression) of GFAP in Nucleus
19) Confidence 0.77 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.19 Pain Relevance 0.95
In the present study we have checked the effects of yohimbine on morphine-induced alterations of the expression of key proteins (glial fibrillary acidic protein, GFAP) and genes (alpha(2)-adrenoceptors) in rat brain areas known to be relevant in opioid dependence, addiction and individual vulnerability to drug abuse.
Gene_expression (expression) of GFAP in brain associated with addiction, drug abuse, opioid and morphine
20) Confidence 0.77 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.19 Pain Relevance 0.82

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