INT58423

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.43
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grid2) plasma membrane (Grid2)
Anatomy Link Frequency
juvenile 2
cerebrospinal fluid 2
Grid 1
RBA 1
neurons 1
Grid2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 9 100.00 Very High Very High Very High
substantia gelatinosa 14 99.68 Very High Very High Very High
Enkephalin 4 94.68 High High
Central nervous system 1 92.40 High High
imagery 8 91.72 High High
agonist 3 89.12 High High
headache 2 87.92 High High
Hippocampus 11 86.96 High High
GABAergic 22 83.32 Quite High
Opioid 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Ataxia 10 100.00 Very High Very High Very High
Hydrocephalus 2 94.28 High High
Pressure And Volume Under Development 2 93.08 High High
Headache 2 87.92 High High
Death 3 86.72 High High
Nociception 2 86.00 High High
Poisoning 43 83.12 Quite High
Toxicity 12 72.72 Quite High
Stress 2 53.68 Quite High
Sprains And Strains 3 49.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2’ stock, which was a mixture of 2 different viral particles—L7-GFP and those that expressed Grid-2 cDNA under the L7 promoter.
Gene_expression (expressed) of Grid-2 in Grid
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2666267 Disease Relevance 0 Pain Relevance 0
IgG type of autoantibodies against glutamate receptor delta2 (GluRdelta2) were detected in the serum, but not in the cerebrospinal fluid in his early clinical course.
Neg (not) Gene_expression (detected) of glutamate receptor delta2 in cerebrospinal fluid associated with glutamate receptor
2) Confidence 0.60 Published 2007 Journal Brain Dev. Section Abstract Doc Link 17008044 Disease Relevance 0.37 Pain Relevance 0.22
IgG type of autoantibodies against glutamate receptor delta2 (GluRdelta2) were detected in the serum, but not in the cerebrospinal fluid in his early clinical course.
Neg (not) Gene_expression (detected) of GluRdelta2 in cerebrospinal fluid associated with glutamate receptor
3) Confidence 0.60 Published 2007 Journal Brain Dev. Section Abstract Doc Link 17008044 Disease Relevance 0.37 Pain Relevance 0.22
However, since it was not detectable in adulthood (eight weeks of age), the reduction of subunit gene expression cannot be the direct structural cause of the permanent mild expression of ataxia in Lurcher mice.
Gene_expression (expression) of Lurcher associated with ataxia
4) Confidence 0.58 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.15 Pain Relevance 0.09
Electrophysiological recordings in DCN neurons of Lc/+ strongly support this hypothesis.
Gene_expression (/) of Lc in neurons
5) Confidence 0.58 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1544347 Disease Relevance 0.09 Pain Relevance 0.04
In this study, RT-PCR, western blotting, immunohistochemistry and a patch clamp technique were used examine the functional expression of the GluR5 subunit in the SG of the Vc in juvenile, peripubertal and/or adult mice.
Spec (examine) Gene_expression (expression) of GluR5 subunit in juvenile associated with substantia gelatinosa
6) Confidence 0.13 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513362 Disease Relevance 0.09 Pain Relevance 0.35
Ligand-selectivity analysis of the two binding sites suggested that neither delta ncx binding site had the characteristics expected of the delta 2 receptor, and that the delta ncx-1 site, but not the delta ncx-2 site, was synonymous with the delta 1 receptor.
Neg (neither) Gene_expression (expected) of delta 2 receptor
7) Confidence 0.11 Published 1993 Journal Peptides Section Abstract Doc Link 8284266 Disease Relevance 0 Pain Relevance 0.52
The levels of mRNA and protein expression of the GluR5 subunit in the SG of the Vc were higher in the juvenile mice than in the peripubertal or adult mice.
Gene_expression (expression) of GluR5 subunit in juvenile associated with substantia gelatinosa
8) Confidence 0.10 Published 2010 Journal Brain Res. Section Abstract Doc Link 20513362 Disease Relevance 0.08 Pain Relevance 0.40
AMPA receptors lacking the GluR2 subunit are resistant to blockade by barbiturates in vitro.
Neg (lacking) Gene_expression (lacking) of GluR2 subunit
9) Confidence 0.08 Published 2001 Journal Anesthesiology Section Abstract Doc Link 11374610 Disease Relevance 0 Pain Relevance 0.17
All clonal cultures (n = 11) and natural bloom samples (n = 2) (> 3 million cells/L) of P. bahamense (Figure 4) obtained from the IRL tested positive for STX by HPLC, LC-MS, Ridascreen ELISA, MIST Alert, and RBA assays.
Gene_expression (tested) of LC-MS in RBA
10) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1626430 Disease Relevance 0.29 Pain Relevance 0

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