INT5843

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2011
Negated 6
Speculated 4
Reported most in Abstract
Documents 184
Total Number 189
Disease Relevance 108.20
Pain Relevance 70.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
astrocytes 18
hippocampus 11
CSF 8
spinal 7
microglia 6
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 661 100.00 Very High Very High Very High
nMDA receptor 143 100.00 Very High Very High Very High
Morphine 358 99.98 Very High Very High Very High
Spinal nerve ligature 127 99.98 Very High Very High Very High
opiate 19 99.98 Very High Very High Very High
trigeminal ganglion 55 99.96 Very High Very High Very High
Hippocampus 215 99.90 Very High Very High Very High
Nucleus accumbens 27 99.88 Very High Very High Very High
medulla 53 99.84 Very High Very High Very High
amygdala 19 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 512 100.00 Very High Very High Very High
Sprains And Strains 50 100.00 Very High Very High Very High
Aids-related Complex 11 100.00 Very High Very High Very High
Ocular Hypertension 835 99.98 Very High Very High Very High
Ganglion Cysts 282 99.96 Very High Very High Very High
Nervous System Injury 270 99.96 Very High Very High Very High
Hydrocephalus 1054 99.92 Very High Very High Very High
Glaucoma 287 99.92 Very High Very High Very High
Injury 1489 99.84 Very High Very High Very High
Frailty 16 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A similar increase in GFAP immunoreactivity can be induced by intraocular injections of tetrodotoxin, demonstrating that a reversible manipulation of optic nerve electrical activity is sufficient to regulate LGN astrocytes.
Positive_regulation (increase) of GFAP in LGN associated with tetrodotoxin
1) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874503 Disease Relevance 0 Pain Relevance 0.14
In the present study we show that GFAp is increased in CSF of patients with MS and that the levels correlate with the neurological dysfunction.
Positive_regulation (increased) of GFAp in CSF associated with anesthesia and multiple sclerosis
2) Confidence 0.69 Published 1995 Journal J. Neurol. Sci. Section Abstract Doc Link 8583233 Disease Relevance 0.54 Pain Relevance 0.37
Because the mesolimbic dopamine system is thought to play a critical role in mediating the reinforcing properties of opiates and other drugs of abuse, it is possible that the opiate induction of GFAP and inherent Lewis versus Fischer strain differences in GFAP levels in the VTA may be related to the reinforcing and/or addictive properties of opiates mediated by this brain region, as well as to genetic differences in drug preference.
Spec (possible) Positive_regulation (induction) of GFAP in brain associated with ventral tegmentum, dopamine, opiate and sprains and strains
3) Confidence 0.69 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8228992 Disease Relevance 0.34 Pain Relevance 1.33
Because the mesolimbic dopamine system is thought to play a critical role in mediating the reinforcing properties of opiates and other drugs of abuse, it is possible that the opiate induction of GFAP and inherent Lewis versus Fischer strain differences in GFAP levels in the VTA may be related to the reinforcing and/or addictive properties of opiates mediated by this brain region, as well as to genetic differences in drug preference.
Positive_regulation (induction) of GFAP in brain associated with ventral tegmentum, dopamine, opiate and sprains and strains
4) Confidence 0.69 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8228992 Disease Relevance 0.34 Pain Relevance 1.34
Yohimbine was found to efficiently prevent morphine-induced GFAP upregulation.
Positive_regulation (upregulation) of GFAP associated with morphine
5) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17123717 Disease Relevance 0.21 Pain Relevance 1.26
To evaluate the role of activity, we carried out four experiments: (1) tetrodotoxin (TTX) was injected into the EC to mimic the decreases in afferent drive that occur after lesion; (2) TTX was injected into the EC or hippocampus before producing electrolytic lesions to block any abnormal activity induced during lesion production; (3) the EC was destroyed by aspiration, thus creating a lesion comparable in size to the electrolytic lesion, without passing direct current; (4) seizures were elicited by stimulating the EC of anesthetized rats, to examine whether electrographic seizures alone can induce the same type of increases in GFAP mRNA as lesions.
Positive_regulation (increases) of GFAP mRNA in hippocampus associated with tetrodotoxin, convulsion and hippocampus
6) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0.26 Pain Relevance 0.56
The role of neuronal activity in upregulating GFAP mRNA levels after electrolytic lesions of the entorhinal cortex.
Positive_regulation (upregulating) of GFAP mRNA in cortex
7) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Title Doc Link 8328294 Disease Relevance 0.12 Pain Relevance 0.37
Our results demonstrated that: (1) TTX injections into the EC did not induce the same increases in GFAP mRNA levels that occurred after EC lesions; (2) animals that received TTX injections into the EC prior to lesions exhibited increases in hippocampal GFAP mRNA that were nearly as great as following EC lesions alone; (3) aspiration lesions of the EC resulted in increases in GFAP mRNA that were comparable to those observed after electrolytic lesions; and (4) seizure-inducing stimulation of the EC resulted in 2-fold increases in GFAP mRNA in the hippocampus 24 hr after stimulation rather than the 5-13-fold increases observed after lesions.
Positive_regulation (increases) of GFAP mRNA in hippocampus associated with tetrodotoxin, convulsion and hippocampus
8) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0.26 Pain Relevance 0.49
These results suggest that lesion-induced changes in hippocampal neuronal activity are not solely responsible for inducing the rapid transient increases in GFAP mRNA levels in the hippocampus ipsilateral to EC lesions.
Positive_regulation (increases) of GFAP mRNA in hippocampus associated with hippocampus
9) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0.21 Pain Relevance 0.27
Our results demonstrated that: (1) TTX injections into the EC did not induce the same increases in GFAP mRNA levels that occurred after EC lesions; (2) animals that received TTX injections into the EC prior to lesions exhibited increases in hippocampal GFAP mRNA that were nearly as great as following EC lesions alone; (3) aspiration lesions of the EC resulted in increases in GFAP mRNA that were comparable to those observed after electrolytic lesions; and (4) seizure-inducing stimulation of the EC resulted in 2-fold increases in GFAP mRNA in the hippocampus 24 hr after stimulation rather than the 5-13-fold increases observed after lesions.
Positive_regulation (increases) of GFAP mRNA in hippocampus associated with tetrodotoxin, convulsion and hippocampus
10) Confidence 0.69 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8328294 Disease Relevance 0.25 Pain Relevance 0.48
Pretreatment with gabapentin prevented the upregulation of GFAP, S100B, and NSE in all brain regions of diabetic rats.
Positive_regulation (upregulation) of GFAP in brain
11) Confidence 0.69 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.06 Pain Relevance 0
In the hippocampus the elevation in GFAP was significantly greater in rats housed at 16 and 30 degrees C.
Positive_regulation (elevation) of GFAP in hippocampus associated with hippocampus
12) Confidence 0.69 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.17 Pain Relevance 0.29
TMT led to marked elevations in GFAP levels, a response that was affected by Ta.
Positive_regulation (elevations) of GFAP
13) Confidence 0.69 Published 1995 Journal Neurotoxicology Section Abstract Doc Link 7566691 Disease Relevance 0.17 Pain Relevance 0.29
This anatomically specific pattern of increased GFAP suggests activation of astrocytes by select neural pathways, which likely include afferents of both spinal and nucleus of the solitary tract (NTS) origin.
Positive_regulation (increased) of GFAP in spinal
14) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.16 Pain Relevance 0.85
Significant increases in GFAP immunoreactivity were localized histologically to the lateral and caudal ventrolateral columns of the PAG.
Positive_regulation (increases) of GFAP in lateral associated with central grey
15) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 20109535 Disease Relevance 1.27 Pain Relevance 0.94
The increases in GFAP mRNA levels are not in response to decreases in neuronal activity (as a result of postictal depression), because GFAP mRNA levels are unaffected when neuronal activity is decreased by blocking afferent drive (with tetrodotoxin).
Positive_regulation (increases) of GFAP in neuronal associated with tetrodotoxin and depression
16) Confidence 0.69 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.14
Using a hippocampal kindling model, we demonstrate that kindled seizures lead to many fold increases in mRNA for GFAP in structures which experience electrographic seizures.
Positive_regulation (increases) of GFAP associated with convulsion
17) Confidence 0.69 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 0.87 Pain Relevance 0.09
If seizures are induced repetitively (every other day for many days), levels of GFAP mRNA remain elevated.
Positive_regulation (elevated) of GFAP associated with convulsion
18) Confidence 0.69 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334663 Disease Relevance 1.07 Pain Relevance 0.11
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Glial fibrillary acidic protein associated with aids-related complex
19) Confidence 0.68 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.40
Ipsilateral increase in IR of OX42 and GFAP was observed to occur within 2 days, maximized by day 14, and did not return to contralateral spinal gray matter IR levels by day 84 (time period of study).
Positive_regulation (increase) of GFAP in spinal
20) Confidence 0.67 Published 1998 Journal Glia Section Abstract Doc Link 9562186 Disease Relevance 0.26 Pain Relevance 0.49

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