INT58432

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 18
Disease Relevance 9.40
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr)
cytoplasm (Gsr)
Anatomy Link Frequency
lung 2
macrophages 1
liver 1
granulocytes 1
blood vessels 1
Gsr (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 6 99.32 Very High Very High Very High
Inflammation 190 98.52 Very High Very High Very High
fluoxetine 2 91.04 High High
Eae 8 89.20 High High
Bile 93 86.92 High High
cytokine 157 85.64 High High
antidepressant 4 76.64 Quite High
depression 5 75.00 Quite High
chemokine 91 73.12 Quite High
Paracetamol 2 68.28 Quite High
Disease Link Frequency Relevance Heat
Nutritional Deficiencies 1 99.86 Very High Very High Very High
INFLAMMATION 201 98.52 Very High Very High Very High
Mycobacterial Infection 1016 98.24 Very High Very High Very High
Infection 817 97.52 Very High Very High Very High
Stress 34 96.88 Very High Very High Very High
Apoptosis 5 96.64 Very High Very High Very High
Liver Disease 2 96.00 Very High Very High Very High
Disease 116 92.00 High High
Sprains And Strains 87 88.72 High High
Injury 24 87.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro activation of hepatic glutathione reductase from mice by lobenzarit disodium.
Positive_regulation (activation) of glutathione reductase
1) Confidence 0.70 Published 1993 Journal Agents Actions Section Title Doc Link 8285143 Disease Relevance 0 Pain Relevance 0.07
Conversely, MeHg exposure increased cerebellar glutathione reductase activity (mean percentage inhibition of 70%), and this phenomenon was not affected by C. paludosa co-administration.
Positive_regulation (increased) of glutathione reductase
2) Confidence 0.64 Published 2007 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17651315 Disease Relevance 0.33 Pain Relevance 0
Glutathione reductase activity from mice liver is significantly enhanced by lobenzarit disodium at concentrations between 0.3 and 1.5 mM.
Positive_regulation (enhanced) of Glutathione reductase in liver
3) Confidence 0.47 Published 1993 Journal Agents Actions Section Abstract Doc Link 8285143 Disease Relevance 0 Pain Relevance 0
Finally, since both macrophages and granulocytes express CD11b and high levels of CD45 [21], we used Gr1 to determine which cell population was the predominant CD45high source of IL-1?
Positive_regulation (used) of Gr1 in macrophages
4) Confidence 0.27 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.05 Pain Relevance 0.04
After two weeks of treatment, no change in LPO, reduced glutathione (GSH) levels and antioxidant enzymes were observed except for glutathione reductase (GR) which increased in all the treated groups.
Neg (except) Positive_regulation (increased) of glutathione reductase
5) Confidence 0.18 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.07 Pain Relevance 0
Also, our experimental data showing the accumulation of Gr1+ neutrophils and monocytes on D12 in the M.tuberculosis-infected lung validates our gene expression profiles.
Positive_regulation (accumulation) of Gr1 in lung associated with mycobacterial infection
6) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.34 Pain Relevance 0
No statistical changes were observed for CD62L in the GR-1 population even after IR induction (data not shown).
Positive_regulation (population) of GR-1
7) Confidence 0.15 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.23 Pain Relevance 0
For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?
Positive_regulation (accumulation) of Gr1
8) Confidence 0.12 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.03 Pain Relevance 0.18
Given that our data suggesting that neutrophils and monocytes accumulate prior to activated T cells in the lung, we next addressed whether the early accumulation of Gr1+ neutrophils had an effect on host adaptive immune responses.
Positive_regulation (accumulation) of Gr1 in lung
9) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.70 Pain Relevance 0.03
Unlike the Gr1+ neutrophil population, our studies show the Gr1+ monocyte population increase is transient, suggesting that these inflammatory monocytes probably then undergo differentiation into DCs and macrophages and contribute to effector function.
Positive_regulation (increase) of Gr1 in inflammatory monocytes associated with inflammation
10) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.06 Pain Relevance 0.19
For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?
Positive_regulation (accumulation) of Gr1
11) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.04 Pain Relevance 0.18
For this reason, we experimentally determined the timing of accumulation of Gr1+ neutrophilic population (CD11b+ Gr1+) (Figure 5a) [68] and Gr1+ monocytic population (CD11b?
Positive_regulation (accumulation) of Gr1
12) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.96 Pain Relevance 0.18
Histologically, we observed an increased accumulation of Gr1+ cells around blood vessels on D12 and D15, while Gr1+ cells were observed in the lung interstitium by D21 (Figure 5c).
Positive_regulation (accumulation) of Gr1 in blood vessels associated with infection
13) Confidence 0.11 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.84 Pain Relevance 0.06
Finally, since both macrophages and granulocytes express CD11b and high levels of CD45 [21], we used Gr1 to determine which cell population was the predominant CD45high source of IL-1?
Positive_regulation (used) of Gr1 in granulocytes
14) Confidence 0.09 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.05 Pain Relevance 0.04
Such glutathione depletion can be reached either by nutritional deficiency or by increased glutathione peroxidase and glutathione reductase activities in tissues.
Positive_regulation (increased) of glutathione reductase associated with nutritional deficiencies
15) Confidence 0.09 Published 2007 Journal Mol Syst Biol Section Body Doc Link PMC2673711 Disease Relevance 0.89 Pain Relevance 0.04
The long-term treatment with alpha-tocopherol (10mg/kg) increased the GSH levels in the hippocampus and in the prefrontal cortex and increased the glutathione peroxidase and glutathione reductase activity in the hippocampus (10mg/kg) and in the prefrontal cortex (10-100mg/kg).
Positive_regulation (increased) of glutathione reductase in cortex associated with hippocampus
16) Confidence 0.08 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 20144659 Disease Relevance 0.07 Pain Relevance 0.78
Our specific gating strategy for Gr-1+ cells concentrated on cells that expressed high levels of Gr-1 and were also CD11b+ and CD11c-, which are suggestive of neutrophils [46]–[49] (data not shown).
Positive_regulation (levels) of Gr-1 in neutrophils
17) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731172 Disease Relevance 0.49 Pain Relevance 0.09
Melatonin was more effective than vitamin C, since it not only prevented the free radical-induced damage with greater efficiency but also increased the activity of the antioxidant enzymes glutathione-S transferase and glutathione reductase [78].
Positive_regulation (increased) of glutathione reductase
18) Confidence 0.03 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 1.23 Pain Relevance 0.04

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