INT58435

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 19
Total Number 24
Disease Relevance 15.35
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) response to stress (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
myocardium 1
fat 1
colon 1
brain 1
hearts 1
Hspa1a (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 516 99.92 Very High Very High Very High
Angina 3 98.80 Very High Very High Very High
ischemia 17 97.32 Very High Very High Very High
Inflammation 43 94.88 High High
cytokine 37 93.20 High High
Spinal cord 3 93.20 High High
midbrain 24 92.52 High High
Hippocampus 21 92.12 High High
cerebral cortex 6 91.60 High High
Eae 21 78.88 Quite High
Disease Link Frequency Relevance Heat
Shock 1120 100.00 Very High Very High Very High
Stress 38 100.00 Very High Very High Very High
Targeted Disruption 37 99.88 Very High Very High Very High
Heat Stress Disorders 24 99.72 Very High Very High Very High
Insulin Resistance 275 99.60 Very High Very High Very High
Sprains And Strains 247 99.58 Very High Very High Very High
Diabetes Mellitus 121 99.04 Very High Very High Very High
Cv General 3 Under Development 3 98.80 Very High Very High Very High
Heat Stroke 7 98.20 Very High Very High Very High
Death 9 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a marked difference in individual organ expression of the inducible 72-kDa heat shock protein (HSP72).
Gene_expression (expression) of HSP72 associated with shock
1) Confidence 0.78 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8285289 Disease Relevance 0.59 Pain Relevance 0
These results demonstrate that the overexpression of HSP72 in multiple organs improves survival during heatstroke by reducing hyperthermia, circulatory shock, and cerebral ischemia and damage in mice.
Gene_expression (overexpression) of HSP72 associated with heat stroke, cv general 4 under development, ischemia, shock and fever
2) Confidence 0.78 Published 2006 Journal J. Appl. Physiol. Section Abstract Doc Link 16627676 Disease Relevance 1.65 Pain Relevance 0.19
The transgenic mice overexpressing heat shock protein 72 (HSP72) or antioxidants have been reported to be more resistant to myocardial ischemia/reperfusion injury.
Gene_expression (overexpressing) of HSP72 associated with targeted disruption, reperfusion injury, coronary artery disease, ischemia and shock
3) Confidence 0.76 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.00 Pain Relevance 0.19
HS enhanced the expression of HSP72 in mouse hearts by two- to three-fold, whereas antioxidant enzyme activities (catalase and MnSOD) did not change significantly.
Gene_expression (expression) of HSP72 in hearts associated with heat stress disorders
4) Confidence 0.76 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.01 Pain Relevance 0.22
The Akt phosphorylation induced by insulin was enhanced upon Hsp72 overexpression (Fig. 9A,B).
Gene_expression (overexpression) of Hsp72
5) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.56 Pain Relevance 0
HS+MES extended the duration of Akt phosphorylation through the increase of Hsp72 expression in HepG2 cells
Gene_expression (expression) of Hsp72 associated with shock
6) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.38 Pain Relevance 0
Consequently, this treatment enhanced the insulin-stimulated Akt phosphorylation in HepG2 cells exposed to high glucose similar to Hsp72 overexpression (Fig. 9D,E).
Gene_expression (overexpression) of Hsp72
7) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.85 Pain Relevance 0
To investigate the effect of Hsp72 overexpression, we transfected Hsp72 plasmid in HepG2 cells.
Spec (investigate) Gene_expression (overexpression) of Hsp72
8) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.44 Pain Relevance 0
We next applied HS together with MES to HepG2 cells and determined the Hsp72 expression and the phosphorylation status of Akt.
Spec (determined) Gene_expression (expression) of Hsp72 associated with shock
9) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.63 Pain Relevance 0
The combination treatment of HS and MES for 10 min increased the Hsp72 expression in protein lysates of HepG2 cells (Fig. 9C) isolated 5 h after treatment.
Gene_expression (expression) of Hsp72 associated with shock
10) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.75 Pain Relevance 0
Co-expression of three genes that are typically associated with cellular stress and temperature stimulus (Hspa1a, Haspa1b, and Dnajb1) was detected after morphine treatment.
Gene_expression (expression) of Hspa1a associated with stress and morphine
11) Confidence 0.56 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.91 Pain Relevance 1.05
Expression of Hspa1b was highly correlated with mRNA levels of other heat shock proteins, namely heat shock protein 72 (Hspa1a) and heat shock protein 40 (Dnajb1).
Gene_expression (Expression) of Hspa1a associated with shock
12) Confidence 0.56 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.84 Pain Relevance 0.45
We identified numerous novel morphine-regulated genes (for instance, Olig2 and Camk1g), and a number of transcripts with strain-specific changes in expression (for instance, Hspa1a and Fzd2).
Gene_expression (expression) of Hspa1a associated with sprains and strains and morphine
13) Confidence 0.56 Published 2007 Journal Genome Biol Section Abstract Doc Link PMC2394777 Disease Relevance 0.46 Pain Relevance 1.15
A full-length cDNA for human Hsp72 (Hsp70A1A) was obtained using primers: 5?
Gene_expression (obtained) of Hsp72
14) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0 Pain Relevance 0
A recent report suggests that Hsp72 overexpression improved insulin resistance in high fat-fed mice [24].
Gene_expression (overexpression) of Hsp72 in fat associated with insulin resistance
15) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.10 Pain Relevance 0
Although the core body temperature of the mice was less than 42°C, the method of mild HS that we used was enough to induce the expression of Hsp72 (Fig. 4D).
Gene_expression (expression) of Hsp72 in body associated with shock
16) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.28 Pain Relevance 0.14
Hsp72 plasmid, siRNA and transfection
Gene_expression (transfection) of Hsp72
17) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0 Pain Relevance 0
Hspa8 is similarly expressed in all regions and both conditions while Hspa1a is expressed in all regions only after heat shock.
Gene_expression (expressed) of Hspa1a associated with shock
18) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.10 Pain Relevance 0.27
Data that corroborate the inducible and constitutive expression of Hspa1a (Hsp70) and Hspa8 (Hsc70), respectively, has been shown by western blot of rat brain regions [91].
Gene_expression (expression) of Hspa1a in brain
19) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.07 Pain Relevance 0.17
Recent study demonstrated that expression of HSP72 was significantly up-regulated and NF-?
Gene_expression (expression) of HSP72
20) Confidence 0.44 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.40 Pain Relevance 0.08

General Comments

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