INT58438

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.24
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hspa1a) response to stress (Hspa1a) cytoplasm (Hspa1a)
Anatomy Link Frequency
myocardium 2
heart 2
colon 1
brain 1
Hspa1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 12 99.42 Very High Very High Very High
Angina 3 98.44 Very High Very High Very High
Morphine 172 98.32 Very High Very High Very High
Paracetamol 72 98.08 Very High Very High Very High
anesthesia 4 88.16 High High
cytokine 19 84.28 Quite High
cerebral cortex 2 71.20 Quite High
Hippocampus 7 69.84 Quite High
midbrain 8 68.80 Quite High
Spinal cord 1 67.68 Quite High
Disease Link Frequency Relevance Heat
Shock 55 100.00 Very High Very High Very High
Reperfusion Injury 7 99.80 Very High Very High Very High
Heat Stress Disorders 22 99.76 Very High Very High Very High
Cv Unclassified Under Development 9 99.42 Very High Very High Very High
Toxicity 33 98.44 Very High Very High Very High
Cv General 3 Under Development 3 98.44 Very High Very High Very High
Injury 14 96.56 Very High Very High Very High
Coronary Artery Disease 2 96.20 Very High Very High Very High
Nervous System Malformation 4 94.32 High High
Myocardial Infarction 1 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that HS does not precondition the isolated perfused mice hearts against ischemia/reperfusion injury, despite induction of HSP72.
Positive_regulation (induction) of HSP72 in hearts associated with reperfusion injury, ischemia and heat stress disorders
1) Confidence 0.68 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.06 Pain Relevance 0.18
However, it remains unknown whether whole body heat stress (HS) which may induce HSP72 or endogenous antioxidants affords similar protection in the mouse heart.
Spec (may) Positive_regulation (induce) of HSP72 in heart associated with heat stress disorders
2) Confidence 0.68 Published 1998 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9925359 Disease Relevance 1.03 Pain Relevance 0.21
There was a marked difference in individual organ expression of the inducible 72-kDa heat shock protein (HSP72).
Positive_regulation (inducible) of HSP72 associated with shock
3) Confidence 0.50 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8285289 Disease Relevance 0.59 Pain Relevance 0
Upregulation of Gstm3 and Hspa1a further suggest a protective mechanism.
Positive_regulation (Upregulation) of Hspa1a
4) Confidence 0.49 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688356 Disease Relevance 0.58 Pain Relevance 0.04
The protective effect was associated with a two- to threefold increase in HSP72 protein accumulation, but not antioxidant enzyme activities (catalase and Cu/Zn and Mn SOD) in the myocardium.
Positive_regulation (increase) of HSP72 protein in myocardium
5) Confidence 0.46 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11454553 Disease Relevance 1.16 Pain Relevance 0.14
B transcription could be inhibited by induction of HSP72 through stabilization of I?
Positive_regulation (induction) of HSP72
6) Confidence 0.33 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872229 Disease Relevance 0.43 Pain Relevance 0.09
Recently, polaprezinc is reported to induce HSP70 (HSP72) in rat gastric mucosa, mouse colonic mucosa, human colon cells, and protect against injuries induced by a variety of stimuli [25–27, 48].
Positive_regulation (induce) of HSP72 in colon associated with injury
7) Confidence 0.28 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2803132 Disease Relevance 0.55 Pain Relevance 0.56
For example, the inducible Hsp70 (Hspa1a) is present at extremely low levels in brain, whereas the constitutively expressed Hsp90, Hsc70 an Hsp60 are easily detected [90].
Positive_regulation (inducible) of Hspa1a in brain
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0 Pain Relevance 0.14
We hypothetized that unstable angina influences the myocardium, and investigated the expression of the inducible heat shock protein 72 (HSP72), constitutive HSP73, and endothelial nitric oxide synthase (eNOS), and activation of the transcription factors NFkappaB and AP-1 in cardiac tissue.
Spec (investigated) Positive_regulation (inducible) of HSP72 in myocardium associated with angina and shock
9) Confidence 0.22 Published 2000 Journal Cardiovasc. Res. Section Abstract Doc Link 10869529 Disease Relevance 0.53 Pain Relevance 0.26
For instance, gene transcription of heat shock proteins Hspa1a and Hspa1b was increased.
Positive_regulation (increased) of Hspa1a associated with shock
10) Confidence 0.19 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.31 Pain Relevance 0.29

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